gene 1,372 words KG: HSPD1
Contents

HSPD1 Gene - Heat Shock Protein Family D Member 1

🧬 Gene Info
Gene SymbolHSPD1
Full NameHeat Shock Protein Family D Member 1
AliasesPage for HSPD1 Gene
Chromosome2q33.1
Protein TypeChaperone
FunctionHSPD1/Hsp60 is a key mitochondrial chaperone
Primary Expressionall tissues with high energy requirements:
PathwaysMitophagy
UniProt IDP10828
NCBI Gene ID3329
Ensembl IDENSG00000134375
OMIM118190
GeneCardsHSPD1
Human Protein AtlasHSPD1
Associated DiseasesAging, Carcinoma
InteractionsAIFM1, AKT, AMPK, AND, APOPTOSIS, ATF3
KG Connections220 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

Related Hypotheses (9)

CYP46A1 Overexpression Gene Therapy
Score: 0.92
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.91
Near-infrared light therapy stimulates COX4-dependent mitoch
Score: 0.74
TFAM overexpression creates mitochondrial donor-recipient gr
Score: 0.73
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69

Related Analyses (9)

Epigenetic reprogramming in aging neurons
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · completed

Related Experiments (1)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40

See Also (15)

AMPK (AMP-Activated Protein Kinase)
entity · KG edge: interacts_with
Apoptosis in Neurodegeneration
entity · KG edge: expressed_in
Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: activates
Genes
index · KG edge: expressed_in
ATF3 Gene
gene · KG edge: activates

Knowledge Graph (12 edges)

MYO7A activates HSPD1
MAP1LC3B activates HSPD1
OPTN activates HSPD1
PARKIN activates HSPD1
PINK1 activates HSPD1
XBP1 activates HSPD1
ATF3 activates HSPD1
TOMM20 activates HSPD1
PTEN activates HSPD1
USP30 activates HSPD1

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