gene

HSPA1B

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HSPA1B: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

143Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

Page for HSPA1B — Heat Shock Protein 70 Family Member 1B

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🧬 Gene Info

Gene Symbol	HSPA1B
Full Name	Heat Shock Protein 70 Family Member 1B
Chromosome	6p21.33
Protein Type	Chaperone
Function	HSPA1B is located in the major histocompatibility complex class III region on chromosome 6p21.33, adjacent to HSPA1A
Primary Expression	Cerebral cortex, Hippocampus, Widespread
Molecular Weight	70 kDa
UniProt ID	P0DMV8
NCBI Gene ID	3305
OMIM	603338
GeneCards	HSPA1B
Human Protein Atlas	HSPA1B
N-terminal ATPase domain (~45 kDa)	Binds and hydrolyzes ATP, regulating substrate binding
Substrate-binding domain (~25 kDa)	Binds hydrophobic peptide segments of misfolded proteins
C-terminal EEVD motif	Coordinates co-chaperones (Hsp40, Hsp70/Hsp90-organizing protein)
Associated Diseases	AD, ALI, Als, Autoimmune, Cardiovascular
Interactions	ager, AGER, ALS, AMYOTROPHIC LATERAL SCLEROSIS, AND, APOPTOSIS
KG Connections	140 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: HSPA1B — AlphaFold P0DMV8 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

HSPA1B — Heat Shock Protein 70 Family Member 1B

gene · 777 words

→

HSPA1B Protein

protein · 709 words

→

Pathway Diagram

graph TD
    HSPA1B["HSPA1B"]
    HSPA1B -->|"activates"| amyotrophic_lateral_sclerosis["amyotrophic lateral sclerosis"]
    HSPA1B -->|"inhibits"| Carcinoma["Carcinoma"]
    HSPA1B -->|"inhibits"| Ms["Ms"]
    HSPA1B -->|"inhibits"| Cancer["Cancer"]
    HSPA1B -->|"inhibits"| Tumor["Tumor"]
    HSPA1B -->|"expressed in"| Lymphoma["Lymphoma"]
    HSPA1B -->|"expressed in"| Als["Als"]
    HSPA1A["HSPA1A"] -.biomarker for.-> HSPA1B
    UBIQUITIN["UBIQUITIN"] -->|"expressed in"| HSPA1B
    CANCER["CANCER"] -->|"expressed in"| HSPA1B
    BAG3["BAG3"] -->|"expressed in"| HSPA1B
    APOPTOSIS["APOPTOSIS"] -->|"expressed in"| HSPA1B
    UBC["UBC"] -->|"expressed in"| HSPA1B
    HSPD1["HSPD1"] -->|"expressed in"| HSPA1B
    NF__B["NF-KappaB"] -->|"expressed in"| HSPA1B
    DNAJC7["DNAJC7"] -->|"expressed in"| HSPA1B
    HSPA6["HSPA6"] -->|"expressed in"| HSPA1B

Outgoing (89)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:HSPA1B	data_in	dataset_row	0.00
Braak Progression	biomarker_for	process	0.90
Parkinson'S Disease	biomarker_for	disease	0.90
amyotrophic lateral sclerosis	activates	disease	0.80
MICROVASCULAR_COMPLICATIONS	associated_with	phenotype	0.72
tophi	associated_with	disease	0.72
Neuroinflammation	activates	disease	0.65
Inflammation	activates	disease	0.65
Amyotrophic Lateral Sclerosis	activates	disease	0.65
Dementia	activates	disease	0.65
Als	activates	disease	0.65
Cardiovascular	associated_with	disease	0.65
Neurodegeneration	activates	disease	0.65
Tumor	associated_with	disease	0.65
Diabetes	associated_with	disease	0.65
Als	associated_with	disease	0.65
Tumor	expressed_in	disease	0.65
Cancer	expressed_in	disease	0.65
Ms	expressed_in	disease	0.65
Ischemia	biomarker_for	disease	0.65
Carcinoma	inhibits	disease	0.65
Ms	inhibits	disease	0.65
Cancer	inhibits	disease	0.65
Tumor	inhibits	disease	0.65
Ms	biomarker_for	disease	0.65
ALS	associated_with	disease	0.65
Lymphoma	expressed_in	disease	0.65
Als	biomarker_for	disease	0.65
Als	expressed_in	disease	0.65
Autoimmune	associated_with	disease	0.65
blood	expressed_in	cell_type	0.64
HSPH1	expressed_in	gene	0.60
HSPA1L	expressed_in	gene	0.60
HSPA1A	expressed_in	gene	0.60
DNAJC10	expressed_in	gene	0.60
HSPA1A	activates	gene	0.60
UBIQUITIN	associated_with	gene	0.60
TRAF6	associated_with	gene	0.60
SERPINE1	associated_with	gene	0.60
TNFAIP3	associated_with	gene	0.60
CEBPB	associated_with	gene	0.60
IRF1	associated_with	gene	0.60
HSPA8	inhibits	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	activates	gene	0.60
NEURON	activates	gene	0.60
NEUROINFLAMMATION	activates	gene	0.60
RNA	biomarker_for	gene	0.60
HSPA1A	biomarker_for	gene	0.60
STAT3	inhibits	gene	0.60
HSP70	inhibits	gene	0.60

Incoming (54)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:HSPA1B	data_in	dataset_row	0.00
Mir-548Au-3P	regulates	biomarker	0.88
Mir-221-3P	regulates	biomarker	0.88
Mir-23A-5P	regulates	biomarker	0.88
ALS	activates	gene	0.60
GENES	activates	gene	0.60
HLA	interacts_with	gene	0.60
HSPA1A	biomarker_for	gene	0.60
UBIQUITIN	expressed_in	gene	0.60
BAG3	expressed_in	gene	0.60
UBC	expressed_in	gene	0.60
GENES	expressed_in	gene	0.60
DNAJC7	expressed_in	gene	0.60
HSPA6	expressed_in	gene	0.60
DNAJB1	expressed_in	gene	0.60
IKBKB	expressed_in	gene	0.60
C9ORF72	activates	gene	0.60
UBQLN2	activates	gene	0.60
TIA1	activates	gene	0.60
DNAJB1	interacts_with	gene	0.60
HSPD1	expressed_in	gene	0.60
NEURODEGENERATION	activates	gene	0.60
DEMENTIA	activates	gene	0.60
AND	expressed_in	gene	0.60
AGER	associated_with	gene	0.60
HSPA1A	associated_with	gene	0.60
SERPINE1	associated_with	gene	0.60
CEBPB	associated_with	gene	0.60
TNFAIP3	associated_with	gene	0.60
HSP70	inhibits	gene	0.60
STAT3	inhibits	gene	0.60
HSP70	expressed_in	gene	0.60
NF-ΚB	expressed_in	gene	0.60
NF-ΚB	biomarker_for	gene	0.60
GENES	associated_with	gene	0.60
APOPTOSIS	inhibits	gene	0.60
AND	inhibits	gene	0.60
GENES	inhibits	gene	0.60
PHAGOCYTOSIS	expressed_in	gene	0.60
HLA	associated_with	gene	0.60
APOPTOSIS	expressed_in	gene	0.60
AND	associated_with	gene	0.60
HSPA1A	expressed_in	entity	0.60
HSPA1A	regulates	entity	0.60
CANCER	expressed_in	gene	0.60
AGER	interacts_with	gene	0.60
HSP70	activates	gene	0.55
HSP40	activates	gene	0.55
DNAJB1	activates	gene	0.55
DNMT1	activates	gene	0.55

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning HSPA1B in their description or question text

No additional research found