protein

DNAJC10

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DNAJC10: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

40Connections

0Hypotheses

0Analyses

20Outgoing

20Incoming

0Experiments

0Debates

Summary

DNAJC10 is a protein involved in neurodegeneration research. Key relationships include: expressed in, implicated in. Associated with Cancer, Lymphoma, Ms. Connected to 28 entities in the SciDEX knowledge graph.

View on Wiki →

No AI portrait yet

🔬 Protein Info

Gene Symbol	DNAJC10
Full Name	DnaJ Heat Shock Protein Family (Hsp40) Member C10
Aliases	ERdj5
Protein Type	Chaperone
Function	DNAJC10/ERdj5 possesses multiple domains and functions
Primary Expression	cortex, hippocampus, and various brain regions - Cellular Localization: ER lumen, with some
Subcellular Localization	the endoplasmic reticulum (ER) where it plays critical roles in protein folding, quality control, and ER-associated degr
Molecular Weight	90.6 kDa
Amino Acids	70 aa
GeneCards	DNAJC10
Human Protein Atlas	DNAJC10
J Domain	Binds to Hsp70 family proteins and stimulates their ATPase activity
Client Binding Domain	Recognizes and binds to misfolded proteins
Thioredoxin Domains	Contains two thioredoxin-like domains with redox activity
ER Localization	Contains an ER retention signal (KDEL or RDEL)
Associated Diseases	neurodegeneration
KG Connections	40 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

DNAJC10 Gene

gene · 699 words

→

DNAJC10 Protein (ERdj5)

protein · 718 words

→

Pathway Diagram

graph TD
    DNAJC10["DNAJC10"]
    Lymphoma{"Lymphoma"}
    DNAJC10 -->|"expressed in"| Lymphoma
    Ms{"Ms"}
    DNAJC10 -->|"expressed in"| Ms
    Cancer{"Cancer"}
    DNAJC10 -->|"expressed in"| Cancer
    Tumor{"Tumor"}
    DNAJC10 -->|"expressed in"| Tumor
    Apoptosis(["Apoptosis"])
    DNAJC10 -->|"expressed in"| Apoptosis
    Unfolded_Protein_Response(["Unfolded Protein Response"])
    DNAJC10 -->|"expressed in"| Unfolded_Protein_Response
    Nf__b(["Nf-Kappab"])
    DNAJC10 -->|"expressed in"| Nf__b
    Phagocytosis(["Phagocytosis"])
    DNAJC10 -->|"expressed in"| Phagocytosis
    neurodegeneration["neurodegeneration"]
    DNAJC10 -->|"implicated in"| neurodegeneration
    UBIQUITIN["UBIQUITIN"]
    UBIQUITIN -->|"expressed in"| DNAJC10
    CANCER["CANCER"]
    CANCER -->|"expressed in"| DNAJC10
    BAG3["BAG3"]
    BAG3 -->|"expressed in"| DNAJC10
    APOPTOSIS["APOPTOSIS"]
    APOPTOSIS -->|"expressed in"| DNAJC10
    UBC["UBC"]
    UBC -->|"expressed in"| DNAJC10
    HSPD1["HSPD1"]
    HSPD1 -->|"expressed in"| DNAJC10
    NF__B["NF-KappaB"]
    NF__B -->|"expressed in"| DNAJC10
    DNAJC7["DNAJC7"]
    DNAJC7 -->|"expressed in"| DNAJC10
    HSPA6["HSPA6"]
    HSPA6 -->|"expressed in"| DNAJC10
    DNAJB1["DNAJB1"]
    DNAJB1 -->|"expressed in"| DNAJC10
    IKBKB["IKBKB"]
    IKBKB -->|"expressed in"| DNAJC10
    HSPA1B["HSPA1B"]
    HSPA1B -->|"expressed in"| DNAJC10
    style DNAJC10 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (20)

Target	Relation	Type	Str
Lymphoma	expressed_in	disease	0.65
Ms	expressed_in	disease	0.65
Cancer	expressed_in	disease	0.65
Tumor	expressed_in	disease	0.65
HSPD1	expressed_in	gene	0.60
HSPH1	expressed_in	gene	0.60
HSP90AB1	expressed_in	gene	0.60
IKBKB	expressed_in	gene	0.60
HSPE1	expressed_in	gene	0.60
HSPA1A	expressed_in	gene	0.60
HSP60	expressed_in	gene	0.60
DNAJB1	expressed_in	gene	0.60
Apoptosis	expressed_in	pathway	0.60
Unfolded Protein Response	expressed_in	pathway	0.60
Nf-Κb	expressed_in	pathway	0.60
NF-ΚB	expressed_in	gene	0.60
Phagocytosis	expressed_in	pathway	0.60
AND	expressed_in	gene	0.60
CANCER	expressed_in	gene	0.60
UBIQUITIN	expressed_in	gene	0.60

Incoming (20)

Source	Relation	Type	Str
GENES	expressed_in	gene	0.60
UBIQUITIN	expressed_in	gene	0.60
BAG3	expressed_in	gene	0.60
UBC	expressed_in	gene	0.60
HSPD1	expressed_in	gene	0.60
DNAJC7	expressed_in	gene	0.60
HSPA6	expressed_in	gene	0.60
DNAJB1	expressed_in	gene	0.60
IKBKB	expressed_in	gene	0.60
HSPA1B	expressed_in	gene	0.60
HSPE1	expressed_in	gene	0.60
HSP90AB1	expressed_in	gene	0.60
HSP70	expressed_in	gene	0.60
HSPH1	expressed_in	gene	0.60
HSPA1L	expressed_in	gene	0.60
HSPA1A	expressed_in	gene	0.60
CANCER	expressed_in	gene	0.60
APOPTOSIS	expressed_in	gene	0.60
NF-ΚB	expressed_in	gene	0.60
PHAGOCYTOSIS	expressed_in	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning DNAJC10 in their description or question text

No additional research found