gene

TIMM10

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TIMM10: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

43Connections

0Hypotheses

0Analyses

6Outgoing

37Incoming

0Experiments

0Debates

Summary

TIMM10 — Mitochondrial Import Inner Membrane Translocase Subunit Tim10

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🧬 Gene Info

Gene Symbol	TIMM10
Full Name	Mitochondrial Import Inner Membrane Translocase Subunit Tim10
Function	TIMM10 (Translocase of Inner Mitochondrial Membrane 10) is a small essential subunit of the TIM22 complex, which mediates the insertion of carrier proteins into the inner mitochondrial membrane.
Primary Expression	neurons throughout the CNS - Regional Distribution: High expression in basal ganglia, hippocampus, and motor [cortex
Pathways	Unfolded Protein Response, Mitophagy, Mtor
GeneCards	TIMM10
Human Protein Atlas	TIMM10
Cellular respiration	Proper assembly of the electron transport chain
Metabolic regulation	Transport of substrates and products
Calcium homeostasis	Mitochondrial calcium uptake
[Apoptosis](/entities/apoptosis)	Release of cytochrome c and other pro-apoptotic factors [2]
Brain	Widely expressed in neurons throughout the CNS
Regional Distribution	High expression in basal ganglia, hippocampus, and motor cortex
Upregulation	Induced during mitochondrial biogenesis and in response to mitochondrial stress
Cellular Localization	Mitochondrial intermembrane space
Associated Diseases	neurodegeneration
Interactions	BECN1, BNIP3, BNIP3L, CEBPB, DDIT3, DNM1L
KG Connections	43 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    TIMM10["TIMM10"]
    Heart_Failure{"Heart Failure"}
    TIMM10 -->|"inhibits"| Heart_Failure
    Ms{"Ms"}
    TIMM10 -->|"inhibits"| Ms
    DNM1L["DNM1L"]
    TIMM10 -->|"inhibits"| DNM1L
    Unfolded_Protein_Response(["Unfolded Protein Response"])
    TIMM10 -->|"inhibits"| Unfolded_Protein_Response
    Mitophagy(["Mitophagy"])
    TIMM10 -->|"inhibits"| Mitophagy
    Mtor(["Mtor"])
    TIMM10 -->|"inhibits"| Mtor
    neurodegeneration["neurodegeneration"]
    TIMM10 -->|"implicated in"| neurodegeneration
    BNIP3["BNIP3"]
    BNIP3 -->|"inhibits"| TIMM10
    VDAC1["VDAC1"]
    VDAC1 -->|"inhibits"| TIMM10
    FUNDC1["FUNDC1"]
    FUNDC1 -->|"inhibits"| TIMM10
    TOMM20["TOMM20"]
    TOMM20 -->|"inhibits"| TIMM10
    TIMM9["TIMM9"]
    TIMM9 -->|"inhibits"| TIMM10
    TIMM17B["TIMM17B"]
    TIMM17B -->|"inhibits"| TIMM10
    OMA1["OMA1"]
    OMA1 -->|"inhibits"| TIMM10
    TIMM23["TIMM23"]
    TIMM23 -->|"inhibits"| TIMM10
    MTOR["MTOR"]
    MTOR -->|"inhibits"| TIMM10
    NRF1["NRF1"]
    NRF1 -->|"inhibits"| TIMM10
    HSPD1["HSPD1"]
    HSPD1 -->|"inhibits"| TIMM10
    MFN2["MFN2"]
    MFN2 -->|"inhibits"| TIMM10
    style TIMM10 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (6)

Target	Relation	Type	Str
Heart Failure	inhibits	disease	0.65
Ms	inhibits	disease	0.65
DNM1L	inhibits	gene	0.60
Unfolded Protein Response	inhibits	pathway	0.60
Mitophagy	inhibits	pathway	0.60
Mtor	inhibits	pathway	0.60

Incoming (37)

Source	Relation	Type	Str
TOMM20	inhibits	gene	0.60
TIMM9	inhibits	gene	0.60
TIMM17B	inhibits	gene	0.60
OMA1	inhibits	gene	0.60
TIMM23	inhibits	gene	0.60
MTOR	inhibits	gene	0.60
NRF1	inhibits	gene	0.60
HSPD1	inhibits	gene	0.60
MFN2	inhibits	gene	0.60
MFF	inhibits	gene	0.60
BECN1	inhibits	gene	0.60
LONP1	inhibits	gene	0.60
CEBPB	inhibits	gene	0.60
SPG7	inhibits	gene	0.60
MAP1LC3A	inhibits	gene	0.60
DDIT3	inhibits	gene	0.60
JUN	inhibits	gene	0.60
TIMM50	inhibits	gene	0.60
HSPA9	inhibits	gene	0.60
TIMM22	inhibits	gene	0.60
HSPE1	inhibits	gene	0.60
OPA1	inhibits	gene	0.60
LAMP2	inhibits	gene	0.60
BNIP3L	inhibits	gene	0.60
SIRT1	inhibits	gene	0.60
HTRA2	inhibits	gene	0.60
PARK2	inhibits	gene	0.60
PINK1	inhibits	gene	0.60
TIMM17A	inhibits	gene	0.60
EIF2A	inhibits	gene	0.60
TFAM	inhibits	gene	0.60
ULK1	inhibits	gene	0.60
MITOPHAGY	inhibits	gene	0.60
MITOCHONDRIAL DYSFUNCTION	inhibits	gene	0.60
BNIP3	inhibits	gene	0.60
VDAC1	inhibits	gene	0.60
FUNDC1	inhibits	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning TIMM10 in their description or question text

No additional research found