gene

UBC

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about UBC: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

202Connections

2Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

UBC is a gene implicated in neurodegeneration research. Key relationships include: associated with, expressed in, regulates. Associated with ALS, Aging, Als. Connected to 121 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	UBC
Aliases	Ubiquitin C
Chromosome	12q24.31
Protein Type	Enzyme
Function	is a highly conserved 76-amino acid protein that plays a central role in the ubiquitin-proteasome system (UPS) and lysosomal degradation pathways.
Molecular Weight	8.5 kDa
Amino Acids	76 aa
Pathways	NF-κB
GeneCards	UBC
Human Protein Atlas	UBC
Associated Diseases	Als, Alzheimer, Cancer, Ischemia, Ms
Interactions	APP, CTNNB1, EGFR, FN1, GRB2, HSP90AA1
KG Connections	202 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (4)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    UBC["UBC"]
    UBC -->|"expressed in"| Alzheimer["Alzheimer"]
    UBC -->|"expressed in"| Aging["Aging"]
    UBC -->|"expressed in"| Als["Als"]
    UBC -->|"expressed in"| Ms["Ms"]
    UBC -->|"expressed in"| Dementia["Dementia"]
    UBC -->|"expressed in"| Lymphoma["Lymphoma"]
    UBC -->|"expressed in"| Cancer["Cancer"]
    UBC -->|"expressed in"| Tumor["Tumor"]
    UBC -->|"expressed in"| CELF2["CELF2"]
    UBC -->|"expressed in"| JUN["JUN"]
    FYN["FYN"] -->|"expressed in"| UBC
    AGING["AGING"] -->|"expressed in"| UBC
    VCP["VCP"] -->|"interacts"| UBC
    CTNNB1["CTNNB1"] -->|"interacts"| UBC
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -->|"expressed in"| UBC
    EGFR["EGFR"] -->|"interacts"| UBC
    HSP90AA1["HSP90AA1"] -->|"interacts"| UBC
    APP["APP"] -->|"interacts"| UBC
    HSP90AB1["HSP90AB1"] -->|"expressed in"| UBC
    MDM2["MDM2"] -->|"interacts"| UBC

Outgoing (116)

Target	Relation	Type	Str
GFAP	coexpressed_with	protein	0.80
Osteoarthritis	therapeutic_target	disease	0.65
Inflammation	therapeutic_target	disease	0.65
Ms	associated_with	disease	0.65
Lymphoma	expressed_in	disease	0.65
Cancer	expressed_in	disease	0.65
Tumor	biomarker_for	disease	0.65
Cancer	associated_with	disease	0.65
Als	biomarker_for	disease	0.65
Tumor	expressed_in	disease	0.65
ALS	associated_with	disease	0.65
Parkinson	associated_with	disease	0.65
Als	associated_with	disease	0.65
Alzheimer	expressed_in	disease	0.65
Aging	expressed_in	disease	0.65
Als	expressed_in	disease	0.65
Ms	expressed_in	disease	0.65
Dementia	expressed_in	disease	0.65
Als	activates	disease	0.65
Alzheimer	associated_with	disease	0.65
Ischemia	associated_with	disease	0.65
Stroke	regulates	disease	0.65
ATG7	associated_with	gene	0.60
SCA3	associated_with	gene	0.60
ATG12	associated_with	gene	0.60
SQSTM1	associated_with	gene	0.60
BECN1	associated_with	gene	0.60
MITOCHONDRIA	associated_with	gene	0.60
cortex	expressed_in	brain_region	0.60
CGAS-STING	associated_with	gene	0.60
Mitophagy	associated_with	pathway	0.60
Endothelial	associated_with	cell_type	0.60
Macrophage	associated_with	cell_type	0.60
T Cell	associated_with	cell_type	0.60
RNA	associated_with	gene	0.60
ATG3	associated_with	gene	0.60
ATG12	regulates	gene	0.60
ULK1	regulates	gene	0.60
PINK1	regulates	gene	0.60
CSNK2A2	regulates	gene	0.60
VDAC1	regulates	gene	0.60
FUNDC1	regulates	gene	0.60
ACTB	regulates	gene	0.60
GAPDH	regulates	gene	0.60
ZO1	regulates	gene	0.60
SDHA	regulates	gene	0.60
OCLN	regulates	gene	0.60
MFN2	regulates	gene	0.60
STING	associated_with	gene	0.60
CLDN5, OCLN	regulates	gene	0.60

Incoming (86)

Source	Relation	Type	Str
STROKE	co_discussed	gene	0.60
FYN	associated_with	gene	0.60
SRC	associated_with	gene	0.60
CAMK2A	associated_with	gene	0.60
SNCA	associated_with	gene	0.60
SLC6A3	associated_with	gene	0.60
COMT	associated_with	gene	0.60
HOMER1	associated_with	gene	0.60
FYN	expressed_in	gene	0.60
VCP	interacts_with	gene	0.60
CTNNB1	interacts_with	gene	0.60
EGFR	interacts_with	gene	0.60
HSP90AA1	interacts_with	gene	0.60
APP	interacts_with	gene	0.60
HSP90AB1	expressed_in	gene	0.60
MDM2	interacts_with	gene	0.60
HSF1	expressed_in	gene	0.60
GRB2	interacts_with	gene	0.60
CSNK2B	regulates	gene	0.60
TOMM20	therapeutic_target	gene	0.60
UBB	regulates	gene	0.60
CLDN5	regulates	gene	0.60
VDAC1	regulates	gene	0.60
CGAS	associated_with	gene	0.60
PINK1	regulates	gene	0.60
CSNK2A2	regulates	gene	0.60
FUNDC1	regulates	gene	0.60
MAP1LC3B	co_discussed	gene	0.60
PINK1	co_discussed	gene	0.60
APOPTOSIS	expressed_in	gene	0.60
DRD2	associated_with	gene	0.60
AGING	expressed_in	gene	0.60
ALZHEIMER'S DISEASE	expressed_in	gene	0.60
CANCER	expressed_in	gene	0.60
DNAJC7	expressed_in	gene	0.60
HSPA6	expressed_in	gene	0.60
HSP70	expressed_in	gene	0.60
ACTB	regulates	gene	0.60
GAPDH	regulates	gene	0.60
SDHA	regulates	gene	0.60
ULK1	regulates	gene	0.60
OCLN	regulates	gene	0.60
ZO1	regulates	gene	0.60
MAP1LC3B	regulates	gene	0.60
POLR2A	regulates	gene	0.60
LC3B	associated_with	gene	0.60
PHAGOCYTOSIS	expressed_in	gene	0.60
GENES	expressed_in	gene	0.60
UBIQUITIN	expressed_in	gene	0.60
BAG3	expressed_in	gene	0.60

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
C1q effector output is determined more by binding partner id	0.610	neurodegeneration	Does C1q function differ based on subcel
YWHAG-Mediated TFEB Subcellular Targeting	0.549	neurodegeneration	Does TFEB dysfunction cause neurodegener

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (2)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Integrated Bioinformatics Analysis of Screen Mitochondrial Autophagy-Related Cor [PMID:41731906]	Gao Z, Wang Y, Ren Y, Lyu J	J Neurochem	2026	0
Charting the research frontier for viral infections, immunomodulation, and demen [PMID:41561087]	Lee CK, Woodward M, Hohenberg MI, Tang J	Front Cell Infect Microbiol	2025	0

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning UBC in their description or question text

No additional research found

UBC