transcription_factor

ATF3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ATF3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

356Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

ATF3 is an entity related to neurodegeneration research. Key relationships include: activates, therapeutic target, regulates. Associated with ALS, Aging, Als. Connected to 242 entities in the SciDEX knowledge graph.

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Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

ATF3 Gene

gene · 897 words

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ATF3 Protein

protein · 3024 words

→

Pathway Diagram

graph TD
    ATF3["ATF3"] -->|"regulates"| TREM2["TREM2"]
    ATF3["ATF3"] -->|"exacerbates"| neurodegeneration["neurodegeneration"]
    ATF3["ATF3"] -->|"activates"| Aging["Aging"]
    ATF3["ATF3"] -->|"activates"| Cardiovascular["Cardiovascular"]
    ATF3["ATF3"] -->|"activates"| Fibrosis["Fibrosis"]
    ATF3["ATF3"] -->|"therapeutic target"| Fibrosis_1["Fibrosis"]
    MYO7A["MYO7A"] -->|"activates"| ATF3["ATF3"]
    MAP1LC3B["MAP1LC3B"] -->|"activates"| ATF3["ATF3"]
    OPTN["OPTN"] -->|"activates"| ATF3["ATF3"]
    PARKIN["PARKIN"] -->|"activates"| ATF3["ATF3"]
    style ATF3 fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (217)

Target	Relation	Type	Str
Als	activates	disease	0.85
Colorectal Cancer	therapeutic_target	disease	0.75
Fibrosis	activates	disease	0.75
Cancer	therapeutic_target	disease	0.75
Als	therapeutic_target	disease	0.75
Ferroptosis	activates	pathway	0.70
neurons	expressed_in	cell_type	0.70
NF-kB signaling	participates_in	pathway	0.70
Neurodegeneration	regulates	disease	0.65
Gastric Cancer	therapeutic_target	disease	0.65
Tumor	expressed_in	disease	0.65
Tumor	therapeutic_target	disease	0.65
Carcinoma	expressed_in	disease	0.65
Als	regulates	disease	0.65
Glaucoma	regulates	disease	0.65
Infection	therapeutic_target	disease	0.65
Ischemia	activates	disease	0.65
Atherosclerosis	activates	disease	0.65
Hepatocellular Carcinoma	therapeutic_target	disease	0.65
Cardiovascular	associated_with	disease	0.65
Tumor	activates	disease	0.65
Prostate Cancer	therapeutic_target	disease	0.65
Pulmonary Fibrosis	therapeutic_target	disease	0.65
Pancreatic Cancer	therapeutic_target	disease	0.65
Aging	causes	disease	0.65
Senescence	associated_with	disease	0.65
Cancer	expressed_in	disease	0.65
Als	expressed_in	disease	0.65
Metabolic Syndrome	activates	disease	0.65
Hepatitis	activates	disease	0.65
Ms	regulates	disease	0.65
Inflammation	therapeutic_target	disease	0.65
Stroke	activates	disease	0.65
Fibrosis	therapeutic_target	disease	0.65
Hepatitis	therapeutic_target	disease	0.65
Cardiovascular	activates	disease	0.65
Ms	therapeutic_target	disease	0.65
Als	associated_with	disease	0.65
Inflammation	activates	disease	0.65
Aging	activates	disease	0.65
Ms	activates	disease	0.65
Senescence	activates	disease	0.65
Tumor	regulates	disease	0.65
Carcinoma	activates	disease	0.65
ALS	regulates	disease	0.65
Alzheimer	regulates	disease	0.65
Carcinoma	therapeutic_target	disease	0.65
Liver Cancer	therapeutic_target	disease	0.65
Lung Cancer	therapeutic_target	disease	0.65
Alzheimer	associated_with	disease	0.65

Incoming (139)

Source	Relation	Type	Str
FERROPTOSIS	activates	gene	0.70
CANCER	therapeutic_target	gene	0.70
GENES	activates	gene	0.70
GENES	therapeutic_target	gene	0.60
BAMBI	therapeutic_target	gene	0.60
P53	regulates	gene	0.60
INFLAMMATION	therapeutic_target	gene	0.60
ALZHEIMER	regulates	gene	0.60
ALZHEIMER'S DISEASE	regulates	gene	0.60
GENES	regulates	gene	0.60
MICRORNAS	protects_against	gene	0.60
NEURODEGENERATION	regulates	gene	0.60
CYTOKINES	regulates	gene	0.60
AXON REGENERATION	regulates	gene	0.60
MIRNAS	associated_with	gene	0.60
PTEN	activates	gene	0.60
USP30	activates	gene	0.60
FOXO3	activates	gene	0.60
FGF20	therapeutic_target	gene	0.60
BRG1	therapeutic_target	gene	0.60
NRCAM	therapeutic_target	gene	0.60
NOTCH2	therapeutic_target	gene	0.60
EP300	therapeutic_target	gene	0.60
CTNNB1	therapeutic_target	gene	0.60
NEUROD1	therapeutic_target	gene	0.60
MYC	therapeutic_target	gene	0.60
VEGFA	therapeutic_target	gene	0.60
FOXM1	therapeutic_target	gene	0.60
LEF1	therapeutic_target	gene	0.60
SMARCA4	therapeutic_target	gene	0.60
TERT	therapeutic_target	gene	0.60
FZD7	therapeutic_target	gene	0.60
JAG1	therapeutic_target	gene	0.60
MITF	therapeutic_target	gene	0.60
GAIN	therapeutic_target	gene	0.60
AXIN2	therapeutic_target	gene	0.60
CD44	therapeutic_target	gene	0.60
FGF18	therapeutic_target	gene	0.60
TP53	regulates	gene	0.60
UBIQUITIN	regulates	gene	0.60
BCL2	activates	gene	0.60
ANG	activates	gene	0.60
TNF	regulates	gene	0.60
PDGFRB	regulates	gene	0.60
AKT	activates	gene	0.60
SLC31A1	activates	gene	0.60
PER2	activates	gene	0.60
HSP70	activates	gene	0.60
CLOCK	activates	gene	0.60
UBIQUITIN	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning ATF3 in their description or question text

No additional research found