transcription_factor

ATF3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ATF3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

356Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

ATF3 is an entity related to neurodegeneration research. Key relationships include: activates, therapeutic target, regulates. Associated with ALS, Aging, Als. Connected to 242 entities in the SciDEX knowledge graph.

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Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

ATF3 Gene

gene · 897 words

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ATF3 Protein

protein · 3024 words

→

Pathway Diagram

graph TD
    ATF3["ATF3"] -->|"regulates"| TREM2["TREM2"]
    ATF3["ATF3"] -->|"exacerbates"| neurodegeneration["neurodegeneration"]
    ATF3["ATF3"] -->|"activates"| Aging["Aging"]
    ATF3["ATF3"] -->|"activates"| Cardiovascular["Cardiovascular"]
    ATF3["ATF3"] -->|"activates"| Fibrosis["Fibrosis"]
    ATF3["ATF3"] -->|"therapeutic target"| Fibrosis_1["Fibrosis"]
    MYO7A["MYO7A"] -->|"activates"| ATF3["ATF3"]
    MAP1LC3B["MAP1LC3B"] -->|"activates"| ATF3["ATF3"]
    OPTN["OPTN"] -->|"activates"| ATF3["ATF3"]
    PARKIN["PARKIN"] -->|"activates"| ATF3["ATF3"]
    style ATF3 fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (215)

Target	Relation	Type	Str
lipid peroxidation products	increases_risk	mechanism	0.85
Als	activates	disease	0.85
mitochondrial dysfunction	associated_with	mechanism	0.80
Fibrosis	activates	disease	0.75
Colorectal Cancer	therapeutic_target	disease	0.75
Cancer	therapeutic_target	disease	0.75
Als	therapeutic_target	disease	0.75
NF-kB signaling	participates_in	pathway	0.70
neurons	expressed_in	cell_type	0.70
Ferroptosis	activates	pathway	0.70
Ischemia	activates	disease	0.65
Ms	activates	disease	0.65
Tumor	therapeutic_target	disease	0.65
Inflammation	activates	disease	0.65
Metabolic Syndrome	activates	disease	0.65
Stroke	activates	disease	0.65
Hepatitis	activates	disease	0.65
Carcinoma	therapeutic_target	disease	0.65
Inflammation	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Als	associated_with	disease	0.65
Ms	regulates	disease	0.65
Fibrosis	therapeutic_target	disease	0.65
Hepatitis	therapeutic_target	disease	0.65
Tumor	regulates	disease	0.65
Aging	activates	disease	0.65
Tumor	expressed_in	disease	0.65
Cancer	expressed_in	disease	0.65
ALS	associated_with	disease	0.65
Neurodegeneration	regulates	disease	0.65
Glaucoma	regulates	disease	0.65
Als	expressed_in	disease	0.65
Carcinoma	expressed_in	disease	0.65
Als	regulates	disease	0.65
Alzheimer	regulates	disease	0.65
Hepatocellular Carcinoma	therapeutic_target	disease	0.65
Prostate Cancer	therapeutic_target	disease	0.65
Aging	causes	disease	0.65
Pulmonary Fibrosis	therapeutic_target	disease	0.65
Pancreatic Cancer	therapeutic_target	disease	0.65
Gastric Cancer	therapeutic_target	disease	0.65
Tumor	activates	disease	0.65
Senescence	activates	disease	0.65
Atherosclerosis	activates	disease	0.65
Carcinoma	activates	disease	0.65
Cardiovascular	activates	disease	0.65
Cardiovascular	associated_with	disease	0.65
Infection	therapeutic_target	disease	0.65
Liver Cancer	therapeutic_target	disease	0.65
ALS	regulates	disease	0.65

Incoming (141)

Source	Relation	Type	Str
SIRT1	activates	unknown	0.95
NAD+ depletion	activates	mechanism	0.95
CANCER	therapeutic_target	gene	0.70
FERROPTOSIS	activates	gene	0.70
GENES	activates	gene	0.70
OPTINEURIN	activates	gene	0.60
TOMM20	activates	gene	0.60
HSP60	activates	gene	0.60
GRIA2	activates	gene	0.60
COX4I1	activates	gene	0.60
NFKB1	associated_with	gene	0.60
ASC	activates	gene	0.60
MICROGLIA	activates	gene	0.60
ASTROCYTES	activates	gene	0.60
INFLAMMATION	activates	gene	0.60
ZFP36	activates	gene	0.60
HSPB1	activates	gene	0.60
CH25H	activates	gene	0.60
APOPTOSIS	regulates	gene	0.60
ALZHEIMER	regulates	gene	0.60
ALZHEIMER'S DISEASE	regulates	gene	0.60
GENES	regulates	gene	0.60
MICRORNAS	protects_against	gene	0.60
PRKN	activates	gene	0.60
ATP	activates	gene	0.60
MIRNAS	associated_with	gene	0.60
ABCB1	targets	gene	0.60
ALDH1A1	targets	gene	0.60
AND	activates	gene	0.60
GATA2	protects_against	gene	0.60
STAT3	regulates	gene	0.60
PPARG	protects_against	gene	0.60
ESR1	regulates	gene	0.60
NFKB1	protects_against	gene	0.60
BANG	regulates	gene	0.60
NR3C1	protects_against	gene	0.60
MAVS	activates	gene	0.60
DHODH	activates	gene	0.60
HSPD1	activates	gene	0.60
CEBPA	protects_against	gene	0.60
PTGS2	associated_with	gene	0.60
NR3C1	associated_with	gene	0.60
BAX	associated_with	gene	0.60
BCL2	associated_with	gene	0.60
AUTOPHAGY	activates	gene	0.60
APOPTOSIS	activates	gene	0.60
INS	regulates	gene	0.60
ASK1	activates	gene	0.60
LONP1	activates	gene	0.60
CASP3	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning ATF3 in their description or question text

No additional research found