protein

DNAJC7

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DNAJC7: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

62Connections

0Hypotheses

0Analyses

50Outgoing

12Incoming

0Experiments

0Debates

Summary

DNAJC7 is a protein involved in neurodegeneration research. Key relationships include: expressed in, regulates, implicated in. Associated with Als, Amyotrophic Lateral Sclerosis, Cancer. Connected to 33 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	DNAJC7
Full Name	DnaJ Heat Shock Protein Family (Hsp40) Member C7
Chromosome	12q24.31
Function	is an important component in the neurobiology of neurodegenerative diseases.
Subcellular Localization	**: Cytosolic with nuc
Molecular Weight	55 kDa
Amino Acids	70 aa
Pathways	Autophagy, Proteasome, Tdp-43, Ubiquitin-Proteasome
UniProt ID	Q9H0U4
GeneCards	DNAJC7
Human Protein Atlas	DNAJC7
J domain	The defining feature of Hsp40 proteins, approximately 70 amino acids, which interacts with and activates Hsp70 ATPase activity
Gly/Phe-rich region	Flexible region potentially involved in substrate binding
TPR domain	Tetratricopeptide repeat domain that mediates interactions with Hsp90 and other TPR-containing proteins
C-terminal client-binding region	Variable domain involved in substrate recognition
Associated Diseases	ALS, Amyotrophic Lateral Sclerosis
Interactions	HSP90
KG Connections	62 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: DNAJC7 — AlphaFold Q9H0U4 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

DnaJ Heat Shock Protein Family (Hsp40) Member C7

gene · 883 words

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DNAJC7 Protein

protein · 747 words

→

Pathway Diagram

graph TD
    DNAJC7["DNAJC7"]
    Lymphoma{"Lymphoma"}
    DNAJC7 -->|"expressed in"| Lymphoma
    Ms{"Ms"}
    DNAJC7 -->|"expressed in"| Ms
    Cancer{"Cancer"}
    DNAJC7 -->|"expressed in"| Cancer
    Tumor{"Tumor"}
    DNAJC7 -->|"expressed in"| Tumor
    Als{"Als"}
    DNAJC7 -->|"regulates"| Als
    Amyotrophic_Lateral_Sclerosis{"Amyotrophic Lateral Sclerosis"}
    DNAJC7 -->|"regulates"| Amyotrophic_Lateral_Sclerosis
    HSPA6["HSPA6"]
    DNAJC7 -->|"expressed in"| HSPA6
    DNAJB1["DNAJB1"]
    DNAJC7 -->|"expressed in"| DNAJB1
    IKBKB["IKBKB"]
    DNAJC7 -->|"expressed in"| IKBKB
    HSPA1B["HSPA1B"]
    DNAJC7 -->|"expressed in"| HSPA1B
    HSPE1["HSPE1"]
    DNAJC7 -->|"expressed in"| HSPE1
    HSP90AB1["HSP90AB1"]
    DNAJC7 -->|"expressed in"| HSP90AB1
    UBIQUITIN["UBIQUITIN"]
    UBIQUITIN -->|"expressed in"| DNAJC7
    CANCER["CANCER"]
    CANCER -->|"expressed in"| DNAJC7
    BAG3["BAG3"]
    BAG3 -->|"expressed in"| DNAJC7
    APOPTOSIS["APOPTOSIS"]
    APOPTOSIS -->|"expressed in"| DNAJC7
    UBC["UBC"]
    UBC -->|"expressed in"| DNAJC7
    HSPD1["HSPD1"]
    HSPD1 -->|"expressed in"| DNAJC7
    NF__B["NF-KappaB"]
    NF__B -->|"expressed in"| DNAJC7
    style DNAJC7 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (50)

Target	Relation	Type	Str
Aging	regulates	disease	0.65
Lymphoma	expressed_in	disease	0.65
Ms	expressed_in	disease	0.65
Cancer	expressed_in	disease	0.65
Als	regulates	disease	0.65
Amyotrophic Lateral Sclerosis	regulates	disease	0.65
Tumor	expressed_in	disease	0.65
ALS	associated_with	disease	0.65
Amyotrophic Lateral Sclerosis	associated_with	disease	0.65
HSPE1	expressed_in	gene	0.60
HSP90AB1	expressed_in	gene	0.60
HSP70	expressed_in	gene	0.60
HSPH1	expressed_in	gene	0.60
HSPA1L	expressed_in	gene	0.60
HSPA1A	expressed_in	gene	0.60
DNAJC10	expressed_in	gene	0.60
HSF1	regulates	gene	0.60
BAG3	expressed_in	gene	0.60
UBC	expressed_in	gene	0.60
UBIQUITIN	expressed_in	gene	0.60
HSPD1	expressed_in	gene	0.60
HSP60	expressed_in	gene	0.60
SOD1	regulates	gene	0.60
MATRIN3	regulates	gene	0.60
GLT8D1	implicated_in	gene	0.60
KIF5A	implicated_in	gene	0.60
MFSD8	implicated_in	gene	0.60
NEK1	implicated_in	gene	0.60
TBK1	implicated_in	gene	0.60
TBP	implicated_in	gene	0.60
PHAGOCYTOSIS	expressed_in	gene	0.60
Apoptosis	expressed_in	pathway	0.60
Unfolded Protein Response	expressed_in	pathway	0.60
Nf-Κb	expressed_in	pathway	0.60
Phagocytosis	expressed_in	pathway	0.60
ALS	regulates	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	regulates	gene	0.60
GENES	expressed_in	gene	0.60
NF-ΚB	expressed_in	gene	0.60
AND	expressed_in	gene	0.60
CANCER	expressed_in	gene	0.60
Proteasome	regulates	pathway	0.60
Tdp-43	regulates	pathway	0.60
Autophagy	regulates	pathway	0.60
Ubiquitin-Proteasome	regulates	pathway	0.60
HSPA6	expressed_in	gene	0.60
DNAJB1	expressed_in	gene	0.60
IKBKB	expressed_in	gene	0.60
HSPA1B	expressed_in	gene	0.60
Neuron	expressed_in	cell_type	0.55

Incoming (12)

Source	Relation	Type	Str
UBIQUITIN	expressed_in	gene	0.60
BAG3	expressed_in	gene	0.60
UBC	expressed_in	gene	0.60
HSPD1	expressed_in	gene	0.60
UBIQUITIN	regulates	gene	0.60
HSP90	interacts_with	gene	0.60
FUS	regulates	gene	0.60
CANCER	expressed_in	gene	0.60
APOPTOSIS	expressed_in	gene	0.60
NF-ΚB	expressed_in	gene	0.60
CCNF	implicated_in	gene	0.60
CTSF	implicated_in	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning DNAJC7 in their description or question text

No additional research found