gene

CKB

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CKB: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

67Connections
1Hypotheses
1Analyses
48Outgoing
19Incoming
0Experiments
1Debates

Summary

CKB is a gene implicated in neurodegeneration research. Key relationships include: inhibits, interacts with, associated with. Associated with ALS, Als, Cardiac. Connected to 37 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolCKB
FunctionCreatine kinase catalyzes the reversible transfer of a phosphate group from phosphocreatine to ADP
PathwaysCircadian Rhythm, Apoptosis
UniProt IDP12277
Ensembl IDENSG00000136053
GeneCardsCKB
Human Protein AtlasCKB
Energy BufferingMaintains ATP levels during periods of high demand or stress
Energy ShuttlePCr serves as a spatial energy shuttle from mitochondria to cytosol
NeuroprotectionSupports neuronal survival under metabolic stress
Synaptic FunctionProvides energy for synaptic vesicle cycling and ion pump function
Oxidative Stress ProtectionReduces ROS production by maintaining mitochondrial function
Associated DiseasesAls, Diabetes, Stroke, translational_neuroscience
InteractionsAKT, AND, APOPTOSIS, ARNT, Bcl2, BCL2
SciDEX HypothesesCreatine Kinase System Capacity as Neural Energy R
KG Connections67 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING
🔮 Predicted Structure: CKB — AlphaFold P12277 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

CKB Gene

gene · 593 words

CCK-B (CCKBR) Neurons

cell · 898 words

Pathway Diagram

graph TD
    CKB["CKB"]
    AKT["AKT"]
    CKB -->|"inhibits"| AKT
    HNRNPK["HNRNPK"]
    CKB -->|"interacts with"| HNRNPK
    HSPD1["HSPD1"]
    CKB -->|"interacts with"| HSPD1
    PRDX6["PRDX6"]
    CKB -->|"interacts with"| PRDX6
    TPI1["TPI1"]
    CKB -->|"interacts with"| TPI1
    VCL["VCL"]
    CKB -->|"interacts with"| VCL
    LAMP2["LAMP2"]
    CKB -->|"interacts with"| LAMP2
    FLOT2["FLOT2"]
    CKB -->|"interacts with"| FLOT2
    Bcl2["Bcl2"]
    CKB -->|"interacts with"| Bcl2
    IP3R["IP3R"]
    CKB -->|"interacts with"| IP3R
    Als{"Als"}
    CKB -->|"associated with"| Als
    Cardiac{"Cardiac"}
    CKB -->|"inhibits"| Cardiac
    miR_551a["miR-551a"]
    miR_551a -->|"inhibits"| CKB
    miR_483["miR-483"]
    miR_483 -->|"inhibits"| CKB
    Ribc2["Ribc2"]
    Ribc2 -->|"interacts with"| CKB
    Ybx2["Ybx2"]
    Ybx2 -->|"interacts with"| CKB
    Bmal1["Bmal1"]
    Bmal1 -->|"regulates"| CKB
    BCL2["BCL2"]
    BCL2 -->|"inhibits"| CKB
    ARNT["ARNT"]
    ARNT -->|"inhibits"| CKB
    ARNT -->|"activates"| CKB
    BCL2 -->|"activates"| CKB
    BMAL1["BMAL1"]
    BMAL1 -->|"inhibits"| CKB
    CIRCADIAN_RHYTHM["CIRCADIAN RHYTHM"]
    CIRCADIAN_RHYTHM -->|"inhibits"| CKB
    APOPTOSIS["APOPTOSIS"]
    APOPTOSIS -->|"inhibits"| CKB
    style CKB fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (48)

TargetRelationTypeStr
AKTinhibitsprotein0.90
HSPD1interacts_withprotein0.80
PRDX6interacts_withprotein0.80
TPI1interacts_withprotein0.80
VCLinteracts_withprotein0.80

Incoming (19)

SourceRelationTypeStr
miR-551ainhibitsgene0.90
miR-483inhibitsgene0.90
Bmal1regulatesgene0.80
Ribc2interacts_withgene0.80
Ybx2interacts_withgene0.80

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
Creatine Kinase System Capacity as Neural Energy Reserve Bio 0.707 translational neuroscience Which metabolic biomarkers can distingui

Mentioning Analyses (1)

Scientific analyses that reference this entity

Which metabolic biomarkers can distinguish therapeutic response from disease pro

translational neuroscience | 2026-04-04 | 7 hypotheses Top: 0.819

Experiments (0)

Experimental studies targeting or related to this entity

ExperimentTypeDiseaseScoreFeasibilityModelStatusEst. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found

Debates (1)

Multi-agent debates referencing this entity

Which metabolic biomarkers can distinguish therapeutic response from disease pro

closed · Rounds: 4 · Score: 0.92 · 2026-04-04

Related Research

Hypotheses and analyses mentioning CKB in their description or question text

No additional research found