gene

BAG3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about BAG3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

416Connections

2Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

1Debates

Summary

BAG3 is a gene implicated in neurodegeneration research. Key relationships include: associated with, activates, expressed in. Associated with ALS, ALZHEIMERS_DISEASE, Als. Connected to 198 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	BAG3
Full Name	BCL2 Associated Athanogene 3
Chromosome	10q25.2
Function	is an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight	57.5 kDa
Amino Acids	575 aa
Exons	4
Pathways	Autophagy, Complement, Nf-Κb
GeneCards	BAG3
Human Protein Atlas	BAG3
Associated Diseases	Als, Alzheimer's disease, ALZHEIMERS_DISEASE, Amyotrophic Lateral Sclerosis, Astrocyte Phagocytosis
Known Drugs/Compounds	rapamycin
Interactions	ALPHA_SYNUCLEIN, ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, Amyloid-Beta, AMYLOID-BETA
KG Connections	416 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

flowchart TD
    BMAL1["BMAL1
Circadian Regulator"] -->|"regulates"| BAG3["BAG3
Co-chaperone Protein"]
    
    BAG3 -->|"component_of"| CASA["CASA Complex
Chaperone-Assisted
Selective Autophagy"]
    
    BAG3 -->|"participates_in"| MACROAUTOPHAGY["Macroautophagy
Pathway"]
    
    BAG3 -->|"promotes"| NBR1["NBR1
Autophagy Receptor"]
    BAG3 -->|"modulates"| SQSTM1["SQSTM1/p62
Autophagy Adaptor"]
    
    BAG3 -->|"inhibits"| ALPHA_SYNUCLEIN["Alpha-synuclein
Aggregation"]
    BAG3 -->|"inhibits"| TAU["Tau Protein
Aggregation"]
    BAG3 -->|"regulates"| MAPT["MAPT
Microtubule-Associated
Protein Tau"]
    
    BAG3 -->|"enhances"| PHAGOCYTOSIS["Phagocytosis
Clearance Mechanism"]
    
    ALPHA_SYNUCLEIN -->|"causes"| SYNUCLEINOPATHY["Synucleinopathy
alpha-syn Pathology"]
    TAU -->|"causes"| TAUOPATHY["Tauopathy
Tau Pathology"]
    
    SYNUCLEINOPATHY -->|"leads_to"| PARKINSONS["Parkinson's Disease"]
    TAUOPATHY -->|"leads_to"| ALZHEIMERS["Alzheimer's Disease"]
    
    BAG3 -->|"dysfunction_in"| ALS["Amyotrophic
Lateral Sclerosis"]
    BAG3 -->|"dysfunction_in"| HUNTINGTONS["Huntington's Disease"]
    
    style BAG3 fill:#006494
    style CASA fill:#1b5e20
    style MACROAUTOPHAGY fill:#1b5e20
    style PHAGOCYTOSIS fill:#1b5e20
    style NBR1 fill:#1b5e20
    style SQSTM1 fill:#1b5e20
    style BMAL1 fill:#4a1a6b
    style ALPHA_SYNUCLEIN fill:#ef5350
    style TAU fill:#ef5350
    style MAPT fill:#ef5350
    style SYNUCLEINOPATHY fill:#5d4400
    style TAUOPATHY fill:#5d4400
    style PARKINSONS fill:#5d4400
    style ALZHEIMERS fill:#5d4400
    style ALS fill:#5d4400
    style HUNTINGTONS fill:#5d4400

Outgoing (299)

Target	Relation	Type	Str
CASA complex	component_of	protein	0.90
astrocyte phagocytosis	promotes	process	0.90
alpha-synuclein spreading	prevents	phenotype	0.90
Astrocyte Phagocytosis	associated_with	phenotype	0.90
SNCA Spreading	inhibits	phenotype	0.90
Alpha-Synuclein Pathology	protects_against	disease	0.90
Tau Pathology	protects_against	disease	0.90
tau pathology	protects_against	phenotype	0.88
macroautophagy	regulates	process	0.85
Macroautophagy	activates	process	0.85
Macroautophagy	involved_in	process	0.85
Phagocytosis	associated_with	process	0.85
alpha-synuclein	mediates	protein	0.80
TAU	mediates	protein	0.80
alpha-synuclein	mediates_clearance	protein	0.80
Alzheimer's Disease	biomarker_for	disease	0.80
TAU	mediates_clearance	protein	0.80
PHAGOCYTOSIS	activates	phenotype	0.72
ALPHA_SYNUCLEIN	inhibits	protein	0.72
TAU	inhibits	protein	0.72
AUTOPHAGY	associated_with	gene	0.70
Autophagy	associated_with	pathway	0.70
Chaperone	associated_with	pathway	0.70
autophagy pathway	participates_in	pathway	0.70
Alzheimer's disease	associated_with	disease	0.70
MAPT	regulates	protein	0.70
NBR1	regulates	protein	0.70
SQSTM1	regulates	protein	0.70
NBR1	interacts_with	protein	0.70
NBR1	activates	protein	0.70
Parkinson's disease	associated_with	disease	0.70
Tumor	expressed_in	disease	0.65
Stroke	activates	disease	0.65
Ischemia	activates	disease	0.65
Lymphoma	expressed_in	disease	0.65
Als	inhibits	disease	0.65
Cancer	regulates	disease	0.65
Tumor	regulates	disease	0.65
Ms	expressed_in	disease	0.65
Cancer	expressed_in	disease	0.65
Alzheimer	inhibits	disease	0.65
Inflammation	associated_with	disease	0.65
Cardiac	associated_with	disease	0.65
Tauopathy	activates	disease	0.65
Synucleinopathy	activates	disease	0.65
Tumor	interacts_with	disease	0.65
Ischemia	causes	disease	0.65
Stroke	causes	disease	0.65
Huntington	associated_with	disease	0.65
Spinocerebellar Ataxia	associated_with	disease	0.65

Incoming (117)

Source	Relation	Type	Str
Astrocyte-Specific BMAL1 Deletion	upregulates	mechanism	0.95
Astrocytes	expressed_in	cell_type	0.90
astrocyte activation	activates	process	0.85
Astrocyte Activation	upregulates	process	0.85
MAP1LC3B	participates_in	gene	0.80
SQSTM1	participates_in	gene	0.80
BMAL1	regulates	protein	0.72
LGALS3	associated_with	gene	0.60
HSPA8	associated_with	gene	0.60
MCOLN1	associated_with	gene	0.60
SQSTM1	associated_with	gene	0.60
SOD1	associated_with	gene	0.60
BCL2	associated_with	gene	0.60
CTSB	associated_with	gene	0.60
TPP1	associated_with	gene	0.60
GLA	associated_with	gene	0.60
CALCINEURIN	activates	gene	0.60
ATG12	activates	gene	0.60
STUB1	associated_with	gene	0.60
PPARGC1A	associated_with	gene	0.60
TARDBP	associated_with	gene	0.60
TREH	associated_with	gene	0.60
BECN1	associated_with	gene	0.60
GAPDH	associated_with	gene	0.60
PPP3CB	associated_with	gene	0.60
HSPB8	associated_with	gene	0.60
MAP1LC3B	associated_with	gene	0.60
MTOR	associated_with	gene	0.60
BMAL1	activates	gene	0.60
TFEB	associated_with	gene	0.60
LAMP1	associated_with	gene	0.60
P62	associated_with	gene	0.60
LAMP2A	associated_with	gene	0.60
STUB1	interacts_with	gene	0.60
HSPB8	interacts_with	gene	0.60
UBIQUITIN	expressed_in	gene	0.60
CLOCK	activates	gene	0.60
TAU	activates	gene	0.60
DNAJC7	expressed_in	gene	0.60
ATG10	regulates	entity	0.60
ATG12	regulates	entity	0.60
UBIQUITIN	interacts_with	gene	0.60
PROTEIN MISFOLDING	interacts_with	gene	0.60
NEURODEGENERATIVE DISEASES	interacts_with	gene	0.60
CANCER	expressed_in	gene	0.60
PHAGOCYTOSIS	activates	gene	0.60
AMYLOID	activates	gene	0.60
ASTROCYTES	activates	gene	0.60
AUTOPHAGY	associated_with	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	associated_with	gene	0.60

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
BAG3-Mediated Hsp70 Substrate Redistribution	0.540	neurodegeneration	How does controlled lysosomal membrane p
Hsp70 cochaperone BAG3-mediated Autophagy Activation for Syn	0.469	proteomics	Quantitative proteomics of the aging syn

Mentioning Analyses (1)

Scientific analyses that reference this entity

Quantitative proteomics of the aging synapse: protein turnover and aggregation i

proteomics | 2026-04-16 | 7 hypotheses Top: 0.533

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

How does synaptic protein turnover change with age and neurodegeneration, and wh

closed · Rounds: 4 · Score: 0.50 · 2026-04-18

Related Research

Hypotheses and analyses mentioning BAG3 in their description or question text

No additional research found