concept

COX2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about COX2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

170Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

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💡 Concept Info

Name	COX2
Key Genes/Proteins	Actin, AIFM1, ALZHEIMER, ALZHEIMER'S DISEASE, AND, APOPTOSIS
Related Diseases	Alzheimer
Related Pathways	Apoptosis, apoptosis pathway

Wiki Pages (2)

Knowledge base pages for this entity

COX20 Gene - Cytochrome c Oxidase Assembly Factor

gene · 3906 words

→

COX20 Protein (Cytochrome C Oxidase Assembly Factor)

protein · 841 words

→

Pathway Diagram

graph TD
    COX2["COX2"]
    COX2 -->|"activates"| Parkinson["Parkinson"]
    COX2 -->|"activates"| Neurodegeneration["Neurodegeneration"]
    COX2 -->|"activates"| Alzheimer["Alzheimer"]
    COX2 -->|"activates"| Cancer["Cancer"]
    COX2 -->|"activates"| Neuroinflammation["Neuroinflammation"]
    COX2 -->|"activates"| Autophagy["Autophagy"]
    COX2 -->|"activates"| Mtor["Mtor"]
    COX2 -->|"expressed in"| Ferroptosis["Ferroptosis"]
    Rotenone["Rotenone"] -->|"upregulates"| COX2
    LC3["LC3"] -->|"activates"| COX2
    NRF2["NRF2"] -->|"activates"| COX2
    FERROPTOSIS["FERROPTOSIS"] -->|"expressed in"| COX2
    FER["FER"] -->|"expressed in"| COX2
    OXIDATIVE_STRESS["OXIDATIVE STRESS"] -->|"activates"| COX2
    NCOA4["NCOA4"] -->|"expressed in"| COX2
    ROS["ROS"] -->|"activates"| COX2

Outgoing (115)

Target	Relation	Type	Str
FERROPTOSIS	promotes	process	0.80
oxidative stress	upregulates	process	0.80
Parkinson	activates	disease	0.65
Neuroinflammation	activates	disease	0.65
Alzheimer	activates	disease	0.65
Cancer	activates	disease	0.65
Neurodegeneration	activates	disease	0.65
MAP1LC3B	activates	gene	0.60
NDP52	activates	gene	0.60
OPTN	activates	gene	0.60
PARL	activates	gene	0.60
PGAM5	activates	gene	0.60
PHB2	activates	gene	0.60
PINK1	activates	gene	0.60
PRKN	activates	gene	0.60
PTEN	activates	gene	0.60
TOMM20	activates	gene	0.60
TUBB	activates	gene	0.60
cancer	activates	disease	0.60
autophagy pathway	participates_in	pathway	0.60
apoptosis pathway	participates_in	pathway	0.60
ubiquitin-proteasome	participates_in	pathway	0.60
IRE1	activates	gene	0.60
PERK	activates	gene	0.60
GFAP	activates	gene	0.60
MAPK	activates	gene	0.60
NLRP3	activates	gene	0.60
STAT3	activates	gene	0.60
TLR4	activates	gene	0.60
MAPK signaling	participates_in	pathway	0.60
astrocytes	expressed_in	cell_type	0.60
Notch	activates	pathway	0.60
HSP60	activates	gene	0.60
HSPD1	activates	gene	0.60
LC3B	activates	gene	0.60
ferroptosis	activates	process	0.60
GPX4	inhibits	gene	0.60
JAK1	inhibits	gene	0.60
JAK2	inhibits	gene	0.60
NLRP3	inhibits	gene	0.60
NQO1	inhibits	gene	0.60
PCBP1	inhibits	gene	0.60
SLC40A1	inhibits	gene	0.60
STAT1	inhibits	gene	0.60
STAT3	inhibits	gene	0.60
STAT4	inhibits	gene	0.60
TLR4	inhibits	gene	0.60
NF-kB signaling	participates_in	pathway	0.60
oxidative stress response	participates_in	pathway	0.60
JAK-STAT signaling	participates_in	pathway	0.60

Incoming (55)

Source	Relation	Type	Str
Rotenone	upregulates	compound	0.90
HMGB1	inhibits	gene	0.60
NCOR1	inhibits	gene	0.60
MTOR	activates	gene	0.60
ATP5A1	activates	gene	0.60
CALCOCO2	activates	gene	0.60
AND	expressed_in	gene	0.60
APOPTOSIS	activates	gene	0.60
PARKINSON'S DISEASE	activates	gene	0.60
P62	activates	gene	0.60
PARKINSON	activates	gene	0.60
GPX4	expressed_in	gene	0.60
AIFM1	activates	gene	0.60
LC3	activates	gene	0.60
NRF2	activates	gene	0.60
FERROPTOSIS	expressed_in	gene	0.60
FER	expressed_in	gene	0.60
OXIDATIVE STRESS	activates	gene	0.60
NCOA4	expressed_in	gene	0.60
ROS	activates	gene	0.60
ATG5	activates	gene	0.60
NEURON	activates	gene	0.60
XCT	expressed_in	gene	0.60
BCL-2	activates	gene	0.60
BAX	activates	gene	0.60
AUTOPHAGY	activates	gene	0.60
HO-1	activates	gene	0.60
CCL2	expressed_in	gene	0.60
CCL5	expressed_in	gene	0.60
NEURODEGENERATION	activates	gene	0.60
ALZHEIMER	activates	gene	0.60
PRESENILIN-1	regulates	gene	0.60
PRESENILIN	regulates	gene	0.60
NOTCH1	activates	gene	0.60
AND	activates	gene	0.60
ALZHEIMER'S DISEASE	activates	gene	0.60
CANCER	activates	gene	0.60
PSEN1	activates	gene	0.60
ATF6	activates	gene	0.60
CHOP	activates	gene	0.60
ASC	inhibits	gene	0.60
CAT	inhibits	gene	0.60
ATP	activates	gene	0.60
CD8	activates	gene	0.60
MTDNA	activates	gene	0.60
S100A8	activates	gene	0.60
ALZHEIMER'S DISEASE	associated_with	disease	0.48
EGFR	regulates	gene	0.48
BAX	associated_with	gene	0.48
CASP3	associated_with	gene	0.48

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning COX2 in their description or question text

No additional research found