concept

ROTENONE

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about ROTENONE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

43Connections

0Hypotheses

0Analyses

41Outgoing

2Incoming

0Experiments

0Debates

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💡 Concept Info

Name	ROTENONE

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Rotenone-Induced Parkinsonism Model

model · 649 words

→

Pathway Diagram

graph TD
    ROTENONE["ROTENONE"]
    ROTENONE -->|"causes"| Parkinson_Disease["Parkinson Disease"]
    ROTENONE -->|"causes"| Parkinson_s_Disease["Parkinson's Disease"]
    ROTENONE -->|"upregulates"| Ros["Ros"]
    ROTENONE -->|"downregulates"| TH["TH"]
    ROTENONE -->|"causes"| Mitochondrial_Dysfunction["Mitochondrial Dysfunction"]
    ROTENONE -->|"upregulates"| ROS["ROS"]
    ROTENONE -->|"causes"| SH_SY5Y_Dopamine_Neurons["SH-SY5Y Dopamine Neurons"]
    ROTENONE -->|"suppresses"| SH_SY5Y["SH-SY5Y"]
    Nac["Nac"] -.protects against.-> ROTENONE

Outgoing (41)

Target	Relation	Type	Str
Parkinson Disease	causes	disease	0.95
Ros	upregulates	process	0.95
TH	downregulates	gene	0.95
Mitochondrial Complex I	inhibits	enzyme	0.95
PARKINSON'S DISEASE	causes	disease	0.95
MITOCHONDRIA	inhibits	cell_type	0.95
SH-SY5Y	suppresses	cell_type	0.95
SH-SY5Y Dopamine Neurons	causes	cell_type	0.95
ROS	upregulates	process	0.95
Sh-Sy5Y Dopamine Neuron	suppresses	cell_type	0.95
Parkinson's Disease	causes	disease	0.95
Mitochondrial Dysfunction	causes	process	0.95
Motor Symptoms	causes	phenotype	0.92
BAX	upregulates	gene	0.90
SLC7A11	downregulates	gene	0.90
NCOA4	upregulates	gene	0.90
BCL2	downregulates	gene	0.90
CASP3	upregulates	gene	0.90
oxidative stress	causes	process	0.90
Parkinson'S Disease	causes	disease	0.90
COX2	upregulates	gene	0.90
Autophagy	upregulates	process	0.90
Apoptosis	promotes	process	0.90
NEURODEGENERATION	causes	process	0.90
Motor Dysfunction	causes	phenotype	0.90
ASTROCYTES	activates	cell_type	0.90
NEURON	causes	cell_type	0.90
MICROGLIA	activates	cell_type	0.90
Oxidative Stress	upregulates	process	0.90
Neuroinflammation	causes	process	0.90
Dopamine Neuron Loss	causes	phenotype	0.90
GPX4	downregulates	gene	0.90
IL6	upregulates	gene	0.85
TNF	upregulates	gene	0.85
Dopamine Neuron	causes	cell_type	0.85
SNCA	upregulates	gene	0.85
MTOR	downregulates	gene	0.85
Parkinson-Like Symptoms	causes	phenotype	0.85
Airway Injury	causes	phenotype	0.80
Gut Dysbiosis	causes	process	0.80
Parkinson's disease	associated_with	disease	0.70

Incoming (2)

Source	Relation	Type	Str
Nac	protects_against	compound	0.90
vinpocetine	protects_against	drug	0.90

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning ROTENONE in their description or question text

No additional research found