Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about FERROPTOSIS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
FERROPTOSIS is an entity related to neurodegeneration research. Key relationships include: activates, inhibits, associated with. Associated with ALS, ALZHEIMER'S, ALZHEIMER'S DISEASE. Connected to 1915 entities in the SciDEX knowledge graph.
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| Name | FERROPTOSIS |
| Key Genes/Proteins | ABCA7, ABCB1, ACC, ACETYL-COA, ACHE, ACSL4 |
| Related Diseases | Aging |
| Related Pathways | Adaptive Immunity |
Knowledge base pages for this entity
graph TD
FERROPTOSIS["FERROPTOSIS"] -->|"implicated in"| CANCER["CANCER"]
FERROPTOSIS["FERROPTOSIS"] -->|"causes"| CELL_DEATH["CELL_DEATH"]
FERROPTOSIS["FERROPTOSIS"] -->|"causes"| NECROSIS["NECROSIS"]
FERROPTOSIS["FERROPTOSIS"] -->|"associated"| CANCER_1["CANCER"]
FERROPTOSIS["FERROPTOSIS"] -->|"associated"| DSS_INDUCED_ULCERATIVE_COLITIS["DSS-INDUCED_ULCERATIVE_COLITIS"]
FERROPTOSIS["FERROPTOSIS"] -->|"activates"| Alzheimer["Alzheimer"]
AUTOPHAGY["AUTOPHAGY"] -->|"regulates"| FERROPTOSIS["FERROPTOSIS"]
GPX4["GPX4"] -.->|"inhibits"| FERROPTOSIS["FERROPTOSIS"]
LIPID_PEROXIDATION["LIPID_PEROXIDATION"] -->|"causes"| FERROPTOSIS["FERROPTOSIS"]
STING1["STING1"] -->|"causes"| FERROPTOSIS["FERROPTOSIS"]
style FERROPTOSIS fill:#5d4400,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Autophagy | activates | pathway | 1.00 |
| Ischemia | activates | disease | 1.00 |
| Hepatocellular Carcinoma | activates | disease | 1.00 |
| CANCER | regulates | gene | 1.00 |
| INFLAMMATION | therapeutic_target | gene | 1.00 |
| MTOR | therapeutic_target | gene | 1.00 |
| AUTOPHAGY | activates | gene | 1.00 |
| Als | associated_with | disease | 1.00 |
| Apoptosis | activates | pathway | 1.00 |
| Parkinson | associated_with | disease | 1.00 |
| Autophagy | regulates | pathway | 1.00 |
| AUTOPHAGY | regulates | gene | 1.00 |
| Inflammation | therapeutic_target | disease | 1.00 |
| Ferroptosis | inhibits | pathway | 1.00 |
| Ferroptosis | activates | pathway | 1.00 |
| Cancer | regulates | disease | 1.00 |
| AUTOPHAGY | associated_with | gene | 1.00 |
| Neurodegeneration | activates | disease | 1.00 |
| Inflammation | regulates | disease | 1.00 |
| Autophagy | associated_with | pathway | 1.00 |
| Als | activates | disease | 1.00 |
| PARKINSON'S DISEASE | associated_with | gene | 1.00 |
| Apoptosis | associated_with | pathway | 1.00 |
| NEURODEGENERATION | associated_with | disease | 1.00 |
| Ferroptosis | associated_with | pathway | 1.00 |
| Necroptosis | regulates | pathway | 1.00 |
| Oxidative Stress | activates | pathway | 1.00 |
| Stroke | therapeutic_target | disease | 1.00 |
| Carcinoma | activates | disease | 1.00 |
| Autophagy | therapeutic_target | pathway | 1.00 |
| CANCER | activates | gene | 1.00 |
| Cancer | associated_with | disease | 1.00 |
| Alzheimer | associated_with | disease | 1.00 |
| Neurodegeneration | associated_with | disease | 1.00 |
| P62 | activates | gene | 1.00 |
| Apoptosis | regulates | pathway | 1.00 |
| Cardiac | activates | disease | 1.00 |
| Tumor | therapeutic_target | disease | 1.00 |
| Ferroptosis | therapeutic_target | pathway | 1.00 |
| Pyroptosis | regulates | pathway | 1.00 |
| CANCER | inhibits | gene | 1.00 |
| Cancer | inhibits | disease | 1.00 |
| Als | regulates | disease | 1.00 |
| NRF2 | inhibits | gene | 1.00 |
| Cancer | therapeutic_target | disease | 1.00 |
| Inflammation | activates | disease | 1.00 |
| Lipid Metabolism | regulates | pathway | 1.00 |
| INFLAMMATION | activates | gene | 1.00 |
| Tumor | inhibits | disease | 1.00 |
| Mtor | therapeutic_target | pathway | 1.00 |
| Source | Relation | Type | Str |
|---|---|---|---|
| ROS | causes | phenotype | 1.00 |
| CANCER | inhibits | gene | 1.00 |
| autophagy | regulates | pathway | 1.00 |
| ROS | activates | phenotype | 1.00 |
| lipid_peroxidation | causes | phenotype | 1.00 |
| CANCER | regulates | gene | 1.00 |
| GPX4 | inhibits | protein | 1.00 |
| PI3K | activates | gene | 1.00 |
| AUTOPHAGY | therapeutic_target | gene | 1.00 |
| APOPTOSIS | activates | gene | 1.00 |
| Neurodegeneration | associated_with | disease | 1.00 |
| AUTOPHAGY | activates | gene | 1.00 |
| NRF2 | regulates | protein | 1.00 |
| FERROPTOSIS | activates | gene | 1.00 |
| SLC7A11 | inhibits | gene | 1.00 |
| OXIDATIVE STRESS | activates | gene | 1.00 |
| FERROPTOSIS | causes | gene | 1.00 |
| OXIDATIVE STRESS | associated_with | gene | 1.00 |
| AMPK | activates | gene | 1.00 |
| OXIDATIVE STRESS | inhibits | gene | 1.00 |
| INFLAMMATION | therapeutic_target | gene | 1.00 |
| AUTOPHAGY | associated_with | gene | 1.00 |
| APOPTOSIS | associated_with | gene | 1.00 |
| GPX4 | regulates | gene | 1.00 |
| SLC7A11 | activates | gene | 1.00 |
| NRF2 | inhibits | gene | 1.00 |
| GPX4 | activates | gene | 1.00 |
| Neurodegeneration | activates | disease | 1.00 |
| Inflammation | activates | disease | 1.00 |
| CANCER | activates | gene | 1.00 |
| APOPTOSIS | inhibits | gene | 1.00 |
| GPX4 | inhibits | gene | 1.00 |
| NEURODEGENERATION | activates | gene | 1.00 |
| INFLAMMATION | activates | gene | 1.00 |
| Als | inhibits | disease | 1.00 |
| Tumor | activates | disease | 1.00 |
| NRF2 | activates | gene | 1.00 |
| ROS | therapeutic_target | gene | 1.00 |
| KEAP1 | activates | gene | 1.00 |
| AKT | activates | gene | 1.00 |
| Als | therapeutic_target | disease | 1.00 |
| Cancer | activates | disease | 1.00 |
| ROS | therapeutic_target | gene | 1.00 |
| SLC7A11 | inhibits | gene | 1.00 |
| FERROPTOSIS | treats | gene | 1.00 |
| Cancer | treats | disease | 1.00 |
| SLC7A11 | activates | gene | 1.00 |
| FERROPTOSIS | therapeutic_target | gene | 1.00 |
| FERROPTOSIS | implicated_in | gene | 1.00 |
| SLC7A11 | inhibits | gene | 1.00 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| ACSL4-Driven Ferroptotic Priming in Disease-Associated Micro | 0.847 | Alzheimer's Disease | Cell type vulnerability in Alzheimers Di |
| ACSL4-Ferroptotic Priming in Stressed Oligodendrocytes Drive | 0.801 | Alzheimer's Disease | Cell type vulnerability in Alzheimers Di |
| LPCAT3-Mediated Lands Cycle Remodeling as the Primary Ferrop | 0.779 | Alzheimer's Disease | Cell type vulnerability in Alzheimers Di |
| ACSL4-Driven Ferroptotic Priming in Disease-Associated Oligo | 0.779 | Alzheimer's Disease | Cell type vulnerability in Alzheimers Di |
| ALOX15-Driven Enzymatic Ferroptosis in AD Oligodendrocytes v | 0.777 | Alzheimer's Disease | Cell type vulnerability in Alzheimers Di |
| LPCAT3-Mediated Lands Cycle Amplification of Ferroptotic Sub | 0.776 | Alzheimer's Disease | Cell type vulnerability in Alzheimers Di |
| LPCAT3-Mediated Lands Cycle Amplification of Ferroptotic Vul | 0.770 | Alzheimer's Disease | Cell type vulnerability in Alzheimers Di |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-18 | 4 hypotheses Top: 0.538
neurodegeneration | 2026-04-16 | 7 hypotheses Top: 0.680
immunology | 2026-04-15 | 0 hypotheses
neuroinflammation | 2026-04-08 | 0 hypotheses
neurodegeneration | 2026-04-03 | 45 hypotheses Top: 0.990
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| SAHA@LIPO-ANG2 therapeutic efficacy in 5xFAD mice | validation | Alzheimer's disease | 0.900 | 0.00 | 5xFAD transgenic mice | proposed | N/A |
| Transcriptomic profiling and differential expression analysis | exploratory | Alzheimer's disease | 0.900 | 0.00 | 1-month-old APP/PS1 mice cereb | proposed | N/A |
| SIRPα modulation in mouse models of Alzheimer's disease | validation | Alzheimer's disease | 0.900 | 0.00 | mouse models of Alzheimer's di | proposed | N/A |
| Microglial SIRPα expression in human Alzheimer's disease tissue | exploratory | Alzheimer's disease | 0.800 | 0.00 | human brain tissue | proposed | N/A |
| Bioinformatics analysis and hub gene identification | exploratory | Alzheimer's disease | 0.800 | 0.00 | computational analysis of tran | proposed | N/A |
| bEV isolation and LPS quantification from human samples | clinical | Alzheimer's disease | 0.800 | 0.00 | human patients | proposed | N/A |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Transcriptomic cytoarchitecture reveals principles of human neocortex organizati [PMID:37824655] | Jorstad NL, Close J, Johansen N, Yanny A | Science | 2023 | 186 |
| FAK/SRC-JNK axis promotes ferroptosis via upregulating ACSL4 expression. [PMID:41862445] | Qin J, Ma S, Wang J, Huang S, Luan J, He | Cell death & disease | 2026 | 0 |
| Quercetin attenuates ox-LDL-induced endothelial injury by regulating ferroptosis [PMID:41902795] | Gao C, Liu B, Zhang R, Tian J, Xin H | Toxicology mechanisms and meth | 2026 | 0 |
| NEDD8 promotes the ferritinophagy and ferroptosis of neurons in ischemic stroke [PMID:41662890] | Rao W, Huang Y, Li J, Chen Q, Sun J et a | J Stroke Cerebrovasc Dis | 2026 | 0 |
| Inhibition of Ferroptosis in Prostatitis Model by Low Intensity Extracorporeal S [PMID:41714892] | Lin D, Li K, Kuang W, Chen Z, Zhang M | World J Mens Health | 2026 | 0 |
| Deciphering sorafenib resistance in hepatocellular carcinoma via ferroptotic mec [PMID:41763496] | Che L, Zhu L, Zhou L, Zhou Y | Biochim Biophys Acta Rev Cance | 2026 | 0 |
| B4GALT1 deficiency attenuates steatohepatitis by regulating the PPARγ/ACSL4 axis [PMID:41860570] | Chien Y, Xia R, Zhou D, Ai Y, Wu L et al | Hepatol Commun | 2026 | 0 |
| Unraveling the impact of risk factors on the ferroptosis-Alzheimer's disease lin [PMID:41498558] | Singh P, Rath SL | Journal of Alzheimer's disease | 2026 | 0 |
| Resveratrol Alleviates Intervertebral Disc Degeneration by Targeting NCOA4-Media [PMID:41873334] | Song C, Wu X, Chen C, Shen B, He Y, Liu | Drug design, development and t | 2026 | 0 |
| Pan-PPAR agonist bezafibrate alleviates psoriasis by suppressing LCN2-dependent [PMID:41662914] | ["Xin R", "Zhang J", "Zhang Y", "Dai M", | Free radical biology & medicin | 2026 | 0 |
| Acteoside alleviates sepsis-induced acute lung injury by activating the Nrf2 pat [PMID:41895086] | Wang Y, Zhang W, Zhang M, Zhu Y, Wang W, | Tissue & cell | 2026 | 0 |
| Ferroptosis and microglial polarization in retinal vein occlusion: pathological [PMID:41924362] | Xu J, Sun M, Wang C, Ju P, Guan XD, Xie | International journal of ophth | 2026 | 0 |
| Melatonin Alleviates Erastin-Induced Cell Death by Inhibiting Ferroptosis and Am [PMID:40442550] | Wongjaikam S, Siengdee P, Somnus A, Govi | Neurotoxicity research | 2025 | 0 |
| Acyl-CoA synthetase long-chain family member 4-A novel prognostic marker in cuta [PMID:41918944] | Paria S, Lapides R, Saravi B, Rajagopal | Frontiers in medicine | 2025 | 0 |
| Microglial exosome TREM2 ameliorates ferroptosis and neuroinflammation in alzhei [PMID:40640358] | Zhu L, Zhou T, Wu L, Zhu X, Chen L, Zhan | Scientific reports | 2025 | 0 |
| Microbiota-derived lysophosphatidylcholine alleviates Alzheimer's disease pathol [PMID:39510074] | ["Zha Xu", "Liu Xicheng", "Wei Mengping" | Cell metabolism | 2025 | 0 |
| Upregulation of MAM by C99 disrupts ACSL4 activity and phospholipid homeostasis [PMID:41394684] | Montesinos J, Yun TD, Salomón-Cruz ID, A | bioRxiv : the preprint server | 2025 | 0 |
| Danggui Shaoyao San ameliorates Alzheimer's disease by regulating lipid metaboli [PMID:40271063] | Gong K, Zhou S, Xiao L, Xu M, Zhou Y, Lu | Frontiers in pharmacology | 2025 | 0 |
| Single-cell spatial transcriptomics reveals distinct patterns of dysregulation i [PMID:39103533] | Johnston KG, Berackey BT, Tran KM, Gelbe | Molecular psychiatry | 2025 | 0 |
| Deferiprone in Alzheimer Disease: A Randomized Clinical Trial. [PMID:39495531] | Ayton S, Barton D, Brew B, Brodtmann A, | JAMA neurology | 2025 | 0 |
Multi-agent debates referencing this entity
closed · Rounds: 4 · Score: 0.50 · 2026-04-18
closed · Rounds: 5 · Score: 0.59 · 2026-04-16
closed · Rounds: 4 · Score: 0.80 · 2026-04-16
closed · Rounds: 4 · Score: 0.86 · 2026-04-09
closed · Rounds: 4 · Score: 0.95 · 2026-04-03
closed · Rounds: 4 · Score: 0.90 · 2026-04-03