concept

XCT

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about XCT: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

77Connections

1Hypotheses

0Analyses

50Outgoing

27Incoming

1Experiments

0Debates

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💡 Concept Info

Name	XCT
Key Genes/Proteins	AND, APOPTOSIS, ATG5, AUTOPHAGY, BAX, BCL-2
Related Diseases	Als, ALS, Cancer
Related Pathways	Apoptosis, Autophagy

Pathway Diagram

graph TD
    XCT["XCT"]
    XCT -->|"regulates"| cystine["cystine"]
    XCT -->|"activates"| Tumor["Tumor"]
    XCT -->|"transports"| Cancer["Cancer"]
    XCT -->|"target for"| Ferroptosis["Ferroptosis"]
    XCT -->|"activates"| Parkinson["Parkinson"]
    XCT -->|"transports"| Als["Als"]
    NRF2["NRF2"] -->|"regulates"| XCT
    SLC7A11["SLC7A11"] -->|"encodes"| XCT
    Nrf2["Nrf2"] -->|"activates"| XCT
    AND["AND"] -->|"transports"| XCT
    LC3["LC3"] -->|"activates"| XCT

Outgoing (50)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:XCT	data_in	dataset_row	0.00
FERROPTOSIS	inhibits	process	0.80
oxidative stress	downregulates	process	0.80
GPX4	interacts_with	protein	0.75
cystine	regulates	drug	0.72
Tumor	activates	disease	0.65
Cancer	transports	disease	0.65
Als	transports	disease	0.65
ALS	associated_with	disease	0.65
Als	associated_with	disease	0.65
Cancer	therapeutic_target	disease	0.65
Ferroptosis	expressed_in	disease	0.65
Parkinson	activates	disease	0.65
Ferroptosis	therapeutic_target	disease	0.65
HO-1	activates	gene	0.60
P62	activates	gene	0.60
BAX	activates	gene	0.60
BCL-2	activates	gene	0.60
PARKINSON	activates	gene	0.60
Oxidative Stress	activates	pathway	0.60
Autophagy	activates	pathway	0.60
Mtor	activates	pathway	0.60
Apoptosis	activates	pathway	0.60
FERROPTOSIS	transports	gene	0.60
AND	expressed_in	gene	0.60
PARKINSON'S DISEASE	activates	gene	0.60
COX2	expressed_in	gene	0.60
SLC7A11	transports	gene	0.60
AND	transports	gene	0.60
SLC7A11	therapeutic_target	gene	0.60
Caspase	activates	protein	0.60
Α-Synuclein	activates	protein	0.60
NRF2	activates	gene	0.60
oxidative stress response	participates_in	pathway	0.60
ferroptosis	participates_in	pathway	0.60
Neuron	activates	cell_type	0.60
CANCER	transports	gene	0.60
Ferroptosis	transports	pathway	0.60
FERROPTOSIS	therapeutic_target	gene	0.60
MTOR	activates	gene	0.60
ROS	activates	gene	0.60
APOPTOSIS	activates	gene	0.60
AUTOPHAGY	activates	gene	0.60
NCOA4	expressed_in	gene	0.60
FERROPTOSIS	expressed_in	gene	0.60
LC3	activates	gene	0.60
NEURON	activates	gene	0.60
GPX4	expressed_in	gene	0.60
ATG5	activates	gene	0.60
Neuron	expressed_in	cell_type	0.55

Incoming (27)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:XCT	data_in	dataset_row	0.00
NRF2	regulates	protein	0.85
SLC7A11	encodes	gene	0.80
Nrf2	activates	transcription_factor	0.70
AND	transports	gene	0.60
NRF2	activates	gene	0.60
HO-1	activates	gene	0.60
SLC7A11	transports	gene	0.60
MTOR	activates	gene	0.60
BAX	activates	gene	0.60
AUTOPHAGY	activates	gene	0.60
BCL-2	activates	gene	0.60
COX2	expressed_in	gene	0.60
APOPTOSIS	activates	gene	0.60
PARKINSON	activates	gene	0.60
P62	activates	gene	0.60
FERROPTOSIS	therapeutic_target	gene	0.60
FER	expressed_in	gene	0.60
OXIDATIVE STRESS	activates	gene	0.60
NCOA4	expressed_in	gene	0.60
LC3	activates	gene	0.60
ATG5	activates	gene	0.60
NEURON	activates	gene	0.60
ROS	activates	gene	0.60
FERROPTOSIS	expressed_in	gene	0.60
SLC7A11	therapeutic_target	gene	0.60
GPX4	expressed_in	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Microglial xCT/SLC7A11 Selective Inhibition to Reduce Non-Ce	0.620	-	Ferroptosis in ALS and motor neuron dise

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (1)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
Gandouling protection against brain injury in Wilson's disease via SIR	validation	Hepatolenticular degeneration	0.900	0.00	TX mice (Wilson's disease mode	proposed	N/A

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning XCT in their description or question text

No additional research found