gene

PRESENILIN-1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PRESENILIN-1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

161Connections

0Hypotheses

0Analyses

50Outgoing

38Incoming

0Experiments

0Debates

Summary

A gene referenced in 139 knowledge graph relationships. Key connections: regulates Aging (disease); regulates Alzheimer (disease); regulates Parkinson (disease).

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🧬 Gene Info

Gene Symbol	PRESENILIN
Primary Expression	Ca1, Hippocampus, Cortex, Parietal Lobe, Gray Matter
Pathways	autophagy pathway, proteasome pathway, Oxidative Stress, Apoptosis, Autophagy
GeneCards	PRESENILIN
Human Protein Atlas	PRESENILIN
Associated Diseases	Aging, Als, Alzheimer, Alzheimer Disease, Alzheimer'S Disease
Interactions	ABCD3, ACHE, Actin, ADAM10, ALS, ALZHEIMER
KG Connections	1022 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Pathway Diagram

flowchart TD
    PSEN1["PRESENILIN-1"] -->|"forms part of"| GAMMA["Gamma secretase"]
    GAMMA -->|"cleaves"| APP["APP"]
    APP -->|"produces"| ABETA["Amyloid beta"]
    ABETA -->|"accumulates in"| AD["Alzheimer disease"]
    PSEN1 -->|"also affects"| NOTCH["Notch signaling"]
    AD -->|"drives"| NEURO["Neurodegeneration"]
    style PSEN1 fill:#e1bee7,stroke:#6a1b9a,color:#000
    style ABETA fill:#ffe0b2,stroke:#e65100,color:#000
    style AD fill:#ffcdd2,stroke:#b71c1c,color:#000

Outgoing (123)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:PRESENILIN-1	data_in	dataset_row	0.00
Ms	regulates	disease	0.65
Neurodegeneration	regulates	disease	0.65
Parkinson	regulates	disease	0.65
Alzheimer	regulates	disease	0.65
Neurodegeneration	interacts_with	disease	0.65
ALS	interacts_with	disease	0.65
Dementia	interacts_with	disease	0.65
Aging	regulates	disease	0.65
Parkinson	interacts_with	disease	0.65
Frontotemporal Dementia	interacts_with	disease	0.65
Stroke	regulates	disease	0.65
Neurodegeneration	causes	disease	0.65
Alzheimer	activates	disease	0.65
Cancer	activates	disease	0.65
Neurodegeneration	activates	disease	0.65
Alzheimer	associated_with	disease	0.65
Alzheimer	causes	disease	0.65
Aging	causes	disease	0.65
Neuron	activates	cell_type	0.60
Neurogenesis	therapeutic_target	pathway	0.60
Neuron	therapeutic_target	cell_type	0.60
ALZHEIMER	activates	gene	0.60
Epithelial	regulates	cell_type	0.60
AGING	causes	gene	0.60
Synaptic Plasticity	causes	pathway	0.60
Neuron	causes	cell_type	0.60
AMYLOID	causes	gene	0.60
WNT	regulates	gene	0.60
AMYLOID-BETA	regulates	gene	0.60
Wnt	regulates	pathway	0.60
Rb	regulates	protein	0.60
APOPTOSIS	activates	gene	0.60
ALZHEIMER	causes	gene	0.60
NOTCH	activates	gene	0.60
Oxidative Stress	activates	pathway	0.60
Notch	activates	pathway	0.60
Apoptosis	activates	pathway	0.60
App	regulates	protein	0.60
PRESENILIN-2	causes	gene	0.60
AMYLOID	activates	gene	0.60
MITOCHONDRIA	associated_with	gene	0.60
AMYLOID	regulates	gene	0.60
OXIDATIVE STRESS	regulates	gene	0.60
PSEN1	activates	gene	0.60
EGFR	regulates	gene	0.60
NOTCH1	activates	gene	0.60
GAIN	causes	gene	0.60
PSEN1	causes	gene	0.60
APP	causes	gene	0.60

Incoming (38)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:PRESENILIN-1	data_in	dataset_row	0.00
ALPHA-SYNUCLEIN	regulates	gene	0.60
HUNTINGTIN	regulates	gene	0.60
BCL-2	associated_with	gene	0.60
AMYLOID	regulates	gene	0.60
OXIDATIVE STRESS	regulates	gene	0.60
ALZHEIMER	regulates	gene	0.60
PSEN2	causes	gene	0.60
APP	causes	gene	0.60
NOTCH	activates	gene	0.60
APOPTOSIS	activates	gene	0.60
AMYLOID-BETA	regulates	gene	0.60
AMYLOID	causes	gene	0.60
NEURODEGENERATIVE DISORDERS	regulates	gene	0.60
PARKINSON	regulates	gene	0.60
AGING	regulates	gene	0.60
EXERCISE	regulates	gene	0.60
PRESENILIN-2	causes	gene	0.60
EGFR	regulates	gene	0.60
PSEN1	activates	gene	0.60
GAIN	causes	gene	0.60
PSEN1	causes	gene	0.60
TAU	regulates	gene	0.60
NEURODEGENERATION	regulates	gene	0.60
PRESENILIN	associated_with	gene	0.60
ALZHEIMER	associated_with	gene	0.60
GENES	causes	gene	0.60
AMYLOID	activates	gene	0.60
ALZHEIMER	causes	gene	0.60
NEURODEGENERATION	activates	gene	0.60
ALZHEIMER	activates	gene	0.60
AGING	causes	gene	0.60
NEURODEGENERATION	causes	gene	0.60
WNT	regulates	gene	0.60
NOTCH1	activates	gene	0.60
APP	interacts_with	gene	0.60
STROKE	regulates	gene	0.60
MITOCHONDRIA	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PRESENILIN-1 in their description or question text

No additional research found