gene 3,906 words KG: COX20
Contents

COX20 Gene - Cytochrome c Oxidase Assembly Factor

🧬 Gene Info
Gene SymbolCOX20
Full NameCytochrome c Oxidase Assembly Factor COX20
AliasesCytochrome c Oxidase Assembly Factor 20, Cytochrome C Oxidase Assembly Factor
Chromosome1p31.3
Functionis a nuclear-encoded mitochondrial protein that plays an indispensable role in the biogenesis of cytochrome c oxidase (Complex IV), the terminal enzyme of the mitochondrial electron transport chain.
Primary ExpressionHigh in cerebellum, inner ear, heart, skeletal muscle
Molecular Weight22 kDa
Amino Acids198 aa
UniProt IDQ9Y4Y6
NCBI Gene ID91574
Ensembl IDENSG00000173391
GeneCardsCOX20
Human Protein AtlasCOX20
Transmembrane domainSingle α-helical transmembrane segment anchors COX20 in the inner mitochondrial membrane
Intermembrane space domainC-terminal region faces the intermembrane space where it interacts with COX1 and other assembly factors
Associated Diseasesneurodegeneration
DatabasesGeneCardsHPASTRING

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Related Hypotheses (6)

CYP46A1 Overexpression Gene Therapy
Score: 0.92
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.91
Near-infrared light therapy stimulates COX4-dependent mitoch
Score: 0.74
TFAM overexpression creates mitochondrial donor-recipient gr
Score: 0.73
Matrix Stiffness Normalization via Targeted Lysyl Oxidase In
Score: 0.71

Related Analyses (5)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
Epigenetic reprogramming in aging neurons
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (13)

Animal Model Comparison for Neurodegenerative Disease Therap
clinical · proposed · Score: 0.40
Endocannabinoid System Dysfunction Validation in Parkinson's
clinical · proposed · Score: 0.40
Glymphatic-Circadian Axis Enhancement Therapy for Parkinson'
clinical · proposed · Score: 0.40
Cytochrome Therapeutics
clinical · proposed · Score: 0.40
Gut Microbiome-Derived Metabolites in Alpha-Synuclein Propag
clinical · proposed · Score: 0.40

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in

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