gene

STAT1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about STAT1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

863Connections

1Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

1Debates

Summary

Page for STAT1 Gene - Signal Transducer and Activator of Transcription 1

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🧬 Gene Info

Gene Symbol	STAT1
Full Name	Signal Transducer and Activator of Transcription 1
Aliases	Page for STAT1 Gene
Chromosome	2q32.2
Protein Type	Transcription Factor
Function	is an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight	84 kDa
Pathways	cascade: ### Activation Mechanism, JAK-STAT signaling, JAK-STAT pathway
UniProt ID	P42224
NCBI Gene ID	6772
Ensembl ID	ENSG00000115415
GeneCards	STAT1
Human Protein Atlas	STAT1
Type I interferons (IFN-α/β)	Primary activators of STAT1 through the IFNAR receptor [7]
Type II interferon (IFN-γ)	Strong activator via the IFNGR receptor, driving MHC class I expression [8]
Associated Diseases	Als, Autoimmune, Depression, Infection, Inflammation
Known Drugs/Compounds	berberine, Curcumin, metformin, valproic acid
Interactions	ACE, AGING, AKT1, alpha-synuclein, ALZHEIMER, ALZHEIMER'S DISEASE
KG Connections	863 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: STAT1 — AlphaFold P42224 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

STAT1 Gene - Signal Transducer and Activator of Transcription 1

gene · 1002 words

→

STAT1 Protein

protein · 965 words

→

Pathway Diagram

graph TD
    STAT1["STAT1"] -->|"Mediates"| INTERFERON_RESPONSE["INTERFERON_RESPONSE"]
    STAT1["STAT1"] -->|"Promotes"| ferroptosis["ferroptosis"]
    STAT1["STAT1"] -->|"Activates"| Cardiovascular["Cardiovascular"]
    STAT1["STAT1"] -->|"Activates"| Als["Als"]
    STAT1["STAT1"] -->|"Activates"| Hypertension["Hypertension"]
    STAT1["STAT1"] -->|"Activates"| Obesity["Obesity"]
    STAT1["STAT1"] -->|"Activates"| Ms["Ms"]
    STAT1["STAT1"] -->|"Activates"| Diabetes["Diabetes"]
    JAK2["JAK2"] -->|"Activates"| STAT1["STAT1"]
    JAK1["JAK1"] -->|"Activates"| STAT1["STAT1"]
    CSF2["CSF2"] -->|"Regulates"| STAT1["STAT1"]
    NAMPT["NAMPT"] -->|"Regulates"| STAT1["STAT1"]
    FGF2["FGF2"] -->|"Regulates"| STAT1["STAT1"]
    style STAT1 fill:#8d4900,color:#e0e0e0
    style INTERFERON_RESPONSE fill:#9C27B0,color:#e0e0e0
    style ferroptosis fill:#1b5e20,color:#e0e0e0
    style Cardiovascular fill:#b71c1c,color:#e0e0e0
    style Als fill:#b71c1c,color:#e0e0e0
    style Hypertension fill:#b71c1c,color:#e0e0e0
    style Obesity fill:#b71c1c,color:#e0e0e0
    style Ms fill:#b71c1c,color:#e0e0e0
    style Diabetes fill:#b71c1c,color:#e0e0e0
    style JAK2 fill:#0d47a1,color:#e0e0e0
    style JAK1 fill:#0d47a1,color:#e0e0e0
    style CSF2 fill:#8d4900,color:#e0e0e0
    style NAMPT fill:#8d4900,color:#e0e0e0
    style FGF2 fill:#8d4900,color:#e0e0e0

Outgoing (518)

Target	Relation	Type	Str
Inflammation	activates	disease	0.95
SARS-CoV-2 Infection	involved_in	disease	0.90
Type I Interferon-Like Gene Signature	mediates	phenotype	0.90
Interferon Response	component_of	pathway	0.90
ULK1	associated_with	gene	0.90
Interferon Response	involved_in	process	0.90
Interferon-Stimulated Gene Response	involved_in	process	0.90
Als	inhibits	disease	0.85
Interferon-Stimulated Genes	component_of	pathway	0.85
Cancer	activates	disease	0.85
ULK1	downregulates	protein	0.85
Parkinson's disease	risk_factor_for	disease	0.85
Microglial Autophagy	regulates	process	0.85
Sepsis	activates	disease	0.85
Lysine Acetylation	involved_in	mechanism	0.82
neural stem cells	inhibits	cell_type	0.80
neural stem cells	activates	cell_type	0.80
CANCER	activates	gene	0.80
INFLAMMATION	activates	gene	0.80
JAK1	activates	gene	0.80
Nf-Κb	activates	pathway	0.80
Als	therapeutic_target	disease	0.75
Carcinoma	activates	disease	0.75
Cancer	inhibits	disease	0.75
Inflammation	inhibits	disease	0.75
Fibrosis	inhibits	disease	0.75
Inflammation	therapeutic_target	disease	0.75
Tumor	activates	disease	0.75
Als	activates	disease	0.75
Als	regulates	disease	0.75
Tumor	therapeutic_target	disease	0.75
Cancer	therapeutic_target	disease	0.75
INTERFERON_RESPONSE	regulates	pathway	0.72
ubiquitin-proteasome	participates_in	pathway	0.70
Jak-Stat	inhibits	pathway	0.70
Tgf-Β	activates	pathway	0.70
Apoptosis	inhibits	pathway	0.70
Nf-Κb	inhibits	pathway	0.70
MTOR	activates	gene	0.70
AKT	regulates	gene	0.70
ferroptosis	activates	process	0.70
INFLAMMATION	inhibits	gene	0.70
TNF-Α	activates	gene	0.70
Mtor	activates	pathway	0.70
DNA	activates	gene	0.70
IFN	activates	gene	0.70
INFLAMMATION	therapeutic_target	gene	0.70
PROINFLAMMATORY CYTOKINES	activates	gene	0.70
JAK	inhibits	gene	0.70
GENES	inhibits	gene	0.70

Incoming (345)

Source	Relation	Type	Str
alpha-synuclein	activates	protein	0.90
Curcumin	inhibits	drug	0.90
Berberine	upregulates	compound	0.90
TNF	activates	gene	0.90
SNCA	interacts_with	protein	0.85
JAK1	phosphorylates	protein	0.85
BAX	regulates	gene	0.80
NF-ΚB	activates	gene	0.80
CYTOKINES	activates	gene	0.80
AKT	therapeutic_target	gene	0.70
CYTOKINES	inhibits	gene	0.70
ERK	regulates	gene	0.70
NF-ΚB	inhibits	gene	0.70
STAT3	activates	gene	0.70
BAX	activates	gene	0.70
APOPTOSIS	inhibits	gene	0.70
IL6	activates	gene	0.70
METFORMIN	associated_with	drug	0.70
CANCER	associated_with	disease	0.70
STAT3	inhibits	gene	0.70
JAK2	activates	protein	0.70
TUMOR MICROENVIRONMENT	regulates	phenotype	0.65
JAK1	activates	protein	0.64
SLC17A7	targets	gene	0.60
GRM5	targets	gene	0.60
SCN8A	targets	gene	0.60
HIF1A	activates	gene	0.60
SQSTM1	activates	gene	0.60
ULK1	inhibits	gene	0.60
CD8	associated_with	gene	0.60
STING	activates	gene	0.60
CGAS	activates	gene	0.60
EGFR	activates	gene	0.60
AKT	regulates	gene	0.60
AND	therapeutic_target	gene	0.60
MAPK	inhibits	gene	0.60
COX2	inhibits	gene	0.60
CCL2	phosphorylates	gene	0.60
BCL-2	regulates	gene	0.60
AND	activates	gene	0.60
HDAC	inhibits	gene	0.60
CDK5	inhibits	gene	0.60
IL6R	activates	gene	0.60
BAX	inhibits	gene	0.60
TNF	inhibits	gene	0.60
CDK5R2	interacts_with	gene	0.60
FGF13	interacts_with	gene	0.60
GRM5	interacts_with	gene	0.60
SCN2B	interacts_with	gene	0.60
SCN8A	interacts_with	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
TYRO3-STAT1 Axis to Preserve Parvalbumin Interneuron Functio	0.506	neuroinflammation	Why do TAM receptors protect against neu

Mentioning Analyses (1)

Scientific analyses that reference this entity

Why do TAM receptors protect against neuroinvasive viruses despite their known i

neuroinflammation | 2026-04-14 | 2 hypotheses Top: 0.513

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

The finding that Mertk/Axl deficiency increases viral susceptibility contradicts

closed · Rounds: 4 · Score: 0.75 · 2026-04-15

Related Research

Hypotheses and analyses mentioning STAT1 in their description or question text

No additional research found