gene

NQO1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NQO1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

280Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

NQO1 is a gene implicated in neurodegeneration research. Key relationships include: activates, therapeutic target, regulates. Associated with Als, Alzheimer, Anxiety. Connected to 113 entities in the SciDEX knowledge graph.

View on Wiki →

No AI portrait yet

🧬 Gene Info

Gene Symbol	NQO1
Full Name	NAD(P)H Quinone Dehydrogenase 1
Aliases	NAD(P
Chromosome	16q22.1
Function	NQO1 uses NAD(P)H as an electron donor to reduce quinones, preventing the formation of toxic semiquinone radicals.
Subcellular Localization	** \| Cytoplasm, also nucleus (minor) \|
Molecular Weight	31 kDa
Amino Acids	274 aa
Pathways	Apoptosis, Ferroptosis
UniProt ID	P15559
NCBI Gene ID	1728
Ensembl ID	ENSG00000100119
OMIM	125860
GeneCards	NQO1
Human Protein Atlas	NQO1
Associated Diseases	Inflammation, Senescence
Interactions	AKT, ALZHEIMER, ALZHEIMER'S DISEASE, AND, ANTIOXIDANT GENES, APOPTOSIS
KG Connections	280 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: NQO1 — AlphaFold P15559 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    NQO1["NQO1"] -->|"biomarker for"| Inflammation["Inflammation"]
    NQO1["NQO1"] -->|"activates"| Inflammation_1["Inflammation"]
    NQO1["NQO1"] -->|"activates"| Obesity["Obesity"]
    NQO1["NQO1"] -->|"associated"| Inflammation_2["Inflammation"]
    NQO1["NQO1"] -.->|"inhibits"| Stroke["Stroke"]
    NQO1["NQO1"] -.->|"inhibits"| Ms["Ms"]
    NRF2["NRF2"] -->|"activates"| NQO1["NQO1"]
    NRF2_3["NRF2"] -->|"regulates"| NQO1["NQO1"]
    GCLC["GCLC"] -->|"regulates"| NQO1["NQO1"]
    GCLM["GCLM"] -->|"regulates"| NQO1["NQO1"]
    style NQO1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (180)

Target	Relation	Type	Str
Oxidative Stress Resistance	mediates	mechanism	0.95
cGAS-Type I Interferon Signaling	inhibits	pathway	0.90
Lipid Peroxidation	inhibits	process	0.90
ROS Levels	downregulates	process	0.90
Glioblastoma Stem Cells	associated_with	cell_type	0.90
NRF2	activates	gene	0.90
Glioblastoma	biomarker_for	disease	0.80
oxidative stress response	participates_in	pathway	0.80
HO-1	activates	gene	0.80
Apoptosis	activates	pathway	0.70
Oxidative Stress	associated_with	pathway	0.70
AKT	activates	gene	0.70
NRF2	regulates	gene	0.70
APOPTOSIS	activates	gene	0.70
CAT	activates	gene	0.70
PI3K	activates	gene	0.70
OXIDATIVE STRESS	activates	gene	0.70
KEAP1	activates	gene	0.70
Oxidative Stress	activates	pathway	0.70
Neuroinflammation	activates	disease	0.65
Als	activates	disease	0.65
Huntington	activates	disease	0.65
Tumor	regulates	disease	0.65
Cancer	activates	disease	0.65
Ms	activates	disease	0.65
Aging	regulates	disease	0.65
Neuroinflammation	regulates	disease	0.65
Ovarian Cancer	regulates	disease	0.65
Lymphoma	activates	disease	0.65
Senescence	associated_with	disease	0.65
Cancer	regulates	disease	0.65
Alzheimer	activates	disease	0.65
Parkinson	therapeutic_target	disease	0.65
Epilepsy	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Inflammation	inhibits	disease	0.65
Inflammation	associated_with	disease	0.65
Inflammation	regulates	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Inflammation	activates	disease	0.65
Stroke	inhibits	disease	0.65
Ms	inhibits	disease	0.65
Anxiety	therapeutic_target	disease	0.65
Stroke	therapeutic_target	disease	0.65
Inflammation	biomarker_for	disease	0.65
Depression	therapeutic_target	disease	0.65
ALS	regulates	disease	0.65
Obesity	activates	disease	0.65
Addiction	therapeutic_target	disease	0.65
Aging	activates	disease	0.65

Incoming (100)

Source	Relation	Type	Str
IPA	upregulates	compound	0.95
Mn And Fe	upregulates	compound	0.95
NFE2L2	upregulates	gene	0.85
NRF2	regulates	protein	0.72
GSH	causes	gene	0.60
TNF	expressed_in	gene	0.60
KEAP1	expressed_in	gene	0.60
NRF2	expressed_in	gene	0.60
NLRP3	expressed_in	gene	0.60
BAX	activates	gene	0.60
LOX	activates	gene	0.60
FSP1	inhibits	gene	0.60
CAT	activates	gene	0.60
INFLAMMATION	inhibits	gene	0.60
OXIDATIVE STRESS	inhibits	gene	0.60
IL-6	expressed_in	gene	0.60
NAD	expressed_in	gene	0.60
STROKE	inhibits	gene	0.60
TLR4	expressed_in	gene	0.60
TXNIP	expressed_in	gene	0.60
SLC40A1	expressed_in	gene	0.60
ASC	expressed_in	gene	0.60
JAK1	expressed_in	gene	0.60
PCBP1	expressed_in	gene	0.60
STAT3	expressed_in	gene	0.60
STAT4	expressed_in	gene	0.60
MYD88	expressed_in	gene	0.60
GR	inhibits	gene	0.60
HO-1	expressed_in	gene	0.60
CANCER	inhibits	gene	0.60
NAD	inhibits	gene	0.60
NEURODEGENERATION	inhibits	gene	0.60
AND	inhibits	gene	0.60
FERROPTOSIS	inhibits	gene	0.60
COX2	inhibits	gene	0.60
SRXN1	regulates	gene	0.60
NADPH	activates	gene	0.60
VEGF	associated_with	gene	0.60
PI3K	therapeutic_target	gene	0.60
AKT	therapeutic_target	gene	0.60
TNF	therapeutic_target	gene	0.60
ASC	inhibits	gene	0.60
GPX4	inhibits	gene	0.60
JAK1	inhibits	gene	0.60
JAK2	inhibits	gene	0.60
NLRP3	inhibits	gene	0.60
OXIDATIVE STRESS	biomarker_for	gene	0.60
GENES	biomarker_for	gene	0.60
INFLAMMATION	biomarker_for	gene	0.60
PARKINSON	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning NQO1 in their description or question text

No additional research found