protein

NCOA4

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NCOA4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

453Connections

1Hypotheses

0Analyses

50Outgoing

50Incoming

1Experiments

0Debates

Summary

NCOA4 is a protein involved in neurodegeneration research. Key relationships include: associated with, regulates, activates. Associated with ALS, Aging, Als. Connected to 236 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	NCOA4
Full Name	Nuclear Receptor Coactivator 4
Chromosome	10q11.23
Protein Type	Receptor
Function	NCOA4 performs two major functions in the cell:
Primary Expression	human tissues: - Brain: Moderate expression in cortex, hippocampus, basal ganglia - Highe
Molecular Weight	70 kDa
Pathways	Akt, Autophagy, FERRITINOPHAGY, Ferroptosis, Iron Metabolism
UniProt ID	Q9UBR1
NCBI Gene ID	8031
Ensembl ID	ENSG00000135333
OMIM	605161
GeneCards	NCOA4
Human Protein Atlas	NCOA4
Associated Diseases	Carcinoma, Cardiovascular, Hepatocellular Carcinoma, Lactation Dysfunction, Parkinson, Tumor
Known Drugs/Compounds	rapamycin, Salidroside
Interactions	ACETYL-COA, ACSL4, ACTB, AGER, ALOX, ALZHEIMER
SciDEX Hypotheses	FUS-ALS-Specific Ferroptosis Vulnerability Through
KG Connections	453 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: NCOA4 — AlphaFold Q9UBR1 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

NCOA4 Gene

gene · 636 words

→

NCOA4 Protein

protein · 537 words

→

Pathway Diagram

flowchart TD
    NCOA4["NCOA4
(Nuclear Receptor
Coactivator 4)"]
    
    FERRITINOPHAGY["Ferritinophagy
(Iron Release
from Ferritin)"]
    AUTOPHAGY["Autophagy
(Cellular Degradation)"]
    FERROPTOSIS["Ferroptosis
(Iron-dependent
Cell Death)"]
    
    IRON_RELEASE["Free Iron
Release"]
    IRON_OVERLOAD["Iron Overload
 and Oxidative Stress"]
    
    GPX4["GPX4
(Glutathione
Peroxidase 4)"]
    SLC7A11["SLC7A11
(Cystine/Glutamate
Antiporter)"]
    
    ALS["Amyotrophic
Lateral Sclerosis
(ALS)"]
    MS["Multiple
Sclerosis
(MS)"]
    PARKINSON["Parkinson's
Disease"]
    
    NEURODEGENERATION["Neuronal
Death and 
Degeneration"]
    THERAPEUTIC["Therapeutic
Target"]
    
    NCOA4 -->|"regulates"| FERRITINOPHAGY
    NCOA4 -->|"regulates"| AUTOPHAGY
    NCOA4 -->|"regulates"| FERROPTOSIS
    
    FERRITINOPHAGY -->|"leads to"| IRON_RELEASE
    IRON_RELEASE -->|"causes"| IRON_OVERLOAD
    IRON_OVERLOAD -->|"promotes"| FERROPTOSIS
    
    NCOA4 -->|"inhibits"| GPX4
    GPX4 -->|"protects against"| FERROPTOSIS
    SLC7A11 -->|"supports"| GPX4
    
    FERROPTOSIS -->|"contributes to"| NEURODEGENERATION
    IRON_OVERLOAD -->|"damages"| NEURODEGENERATION
    
    NEURODEGENERATION -->|"manifests as"| ALS
    NEURODEGENERATION -->|"manifests as"| MS
    NEURODEGENERATION -->|"manifests as"| PARKINSON
    
    NCOA4 -->|"potential"| THERAPEUTIC
    
    style NCOA4 fill:#006494
    style GPX4 fill:#1b5e20
    style SLC7A11 fill:#1b5e20
    style THERAPEUTIC fill:#1b5e20
    style FERROPTOSIS fill:#ef5350
    style IRON_OVERLOAD fill:#ef5350
    style NEURODEGENERATION fill:#ef5350
    style ALS fill:#5d4400
    style MS fill:#5d4400
    style PARKINSON fill:#5d4400
    style FERRITINOPHAGY fill:#4a1a6b
    style AUTOPHAGY fill:#4a1a6b

Outgoing (297)

Target	Relation	Type	Str
Ferritinophagy	mediates	process	0.95
Ferritinophagy	activates	process	0.95
Lactation Dysfunction	causes	phenotype	0.92
ferritinophagy	mediates	process	0.90
Ferritin	mediates	protein	0.90
Ferritin	degrades	protein	0.90
FERRITIN	degrades	entity	0.90
ferritinophagy	regulates	pathway	0.90
Ferroptosis	promotes	process	0.90
Autophagy	associated_with	pathway	0.90
Ferroptosis	activates	pathway	0.90
Lactation Dysfunction	contributes_to	phenotype	0.88
Bovine Mastitis	therapeutic_target	disease	0.88
ferroptosis	regulates	process	0.88
Iron Metabolism	involved_in	pathway	0.85
Als	activates	disease	0.85
FERROPTOSIS	mediates	entity	0.85
Iron Metabolism	regulates	pathway	0.85
Cancer	activates	disease	0.85
Carcinoma	associated_with	disease	0.85
Iron-Dependent Cell Death	modulates	process	0.85
Ferritin Degradation	activates	process	0.85
oxidative stress	upregulates	process	0.80
ferroptosis	participates_in	pathway	0.80
FERROPTOSIS	activates	gene	0.80
CANCER	activates	gene	0.80
Autophagy	regulates	pathway	0.80
Ferroptosis	regulates	pathway	0.80
Hepatocellular Carcinoma	associated_with	disease	0.75
Tumor	activates	disease	0.75
Als	therapeutic_target	disease	0.75
Ischemia	therapeutic_target	disease	0.75
FERRITINOPHAGY	regulates	pathway	0.72
APOPTOSIS	activates	gene	0.70
PTGS2	associated_with	gene	0.70
MTOR	regulates	gene	0.70
Mtor	regulates	pathway	0.70
GPX4	regulates	gene	0.70
Ferroptosis	therapeutic_target	pathway	0.70
oxidative stress response	participates_in	pathway	0.70
FERROPTOSIS	inhibits	gene	0.70
Apoptosis	activates	pathway	0.70
Ferroptosis	inhibits	pathway	0.70
P62	associated_with	gene	0.70
FERROPTOSIS	regulates	gene	0.70
Ferroptosis	involved_in	process	0.70
ALS	activates	disease	0.65
Aging	regulates	disease	0.65
Als	regulates	disease	0.65
Inflammation	regulates	disease	0.65

Incoming (156)

Source	Relation	Type	Str
Klebsiella Pneumoniae	activates	disease	0.90
Rotenone	upregulates	compound	0.90
Klebsiella pneumoniae	upregulates	compound	0.90
STAT3	upstream_of	protein	0.85
Salidroside	modulates	compound	0.85
FTH1	inhibits	gene	0.80
FTH1	associated_with	gene	0.80
ATG	associated_with	gene	0.80
GPX4	associated_with	gene	0.80
AUTOPHAGY	associated_with	gene	0.80
ROS	associated_with	gene	0.80
COL1A1	associated_with	gene	0.70
FTH1	activates	gene	0.70
P62	associated_with	gene	0.70
SLC7A11	associated_with	gene	0.70
ELAVL1	associated_with	gene	0.70
BECN1	associated_with	gene	0.70
SQSTM1	associated_with	gene	0.70
AUTOPHAGY	regulates	gene	0.70
MAP1LC3B	associated_with	gene	0.70
ELAVL1	interacts_with	gene	0.60
FTH1	interacts_with	gene	0.60
GOT1	interacts_with	gene	0.60
GPT	interacts_with	gene	0.60
BECN1	interacts_with	gene	0.60
MAP1LC3B	interacts_with	gene	0.60
GPX4	interacts_with	gene	0.60
DMT1	expressed_in	gene	0.60
FTH1	expressed_in	gene	0.60
DMT1	activates	gene	0.60
MITOCHONDRIAL DNA	associated_with	gene	0.60
ALOX	associated_with	gene	0.60
APOPTOSIS	activates	gene	0.60
FERROPTOSIS	activates	gene	0.60
INFLAMMATION	therapeutic_target	gene	0.60
DNA	activates	gene	0.60
MAO	regulates	gene	0.60
FERROPTOSIS	regulates	gene	0.60
XCT	expressed_in	gene	0.60
MTOR	regulates	gene	0.60
BECN1	mediates	entity	0.60
RAB7A	regulates	gene	0.60
ACTB	interacts_with	gene	0.60
CGAS	associated_with	gene	0.60
TMEM173	associated_with	gene	0.60
ARNTL	associated_with	gene	0.60
FANCD2	associated_with	gene	0.60
UBIQUITIN	interacts_with	gene	0.60
COX2	activates	gene	0.60
HIF	activates	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
FUS-ALS-Specific Ferroptosis Vulnerability Through NCOA4-Med	0.480	-	Ferroptosis in ALS and motor neuron dise

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (1)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
S-equol-induced ferroptosis mechanism in TNBC cells	exploratory	Triple negative breast cancer	0.900	0.00	TNBC cell lines	proposed	N/A

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning NCOA4 in their description or question text

No additional research found