protein

HSP60

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HSP60: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

208Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

Hsp60 protein - mitochondrial chaperonin 60, protein folding, SPG13, neurodegeneration

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🔬 Protein Info

Gene Symbol	HSP60
Full Name	HSP60 (Heat Shock 60)
Aliases	Hsp60 protein, Heat Shock Protein 60
Protein Type	Protein
Function	is a mitochondrial chaperonin protein essential for proper protein folding within the mitochondrion.
Primary Expression	testis and some peripheral tissues
Molecular Weight	60.3 kDa
Pathways	Apoptosis, Autophagy, Mapk, Mitophagy, Nf-Κb
UniProt ID	Search UniProt
GeneCards	HSP60
Human Protein Atlas	HSP60
Heptameric ring	Seven Hsp60 subunits arrange in a ring-like structure, each approximately 60 kDa
Double-barrel architecture	The complex forms two stacked heptameric rings, creating a barrel-shaped chamber approximately 25 nm in diameter
ATP-binding domains	Each subunit contains an ATP-binding pocket in the equatorial domain, required for the conformational changes that drive the folding cycle
Flexible apical domains	The apical domains form the entrance to the folding chamber and interact with client proteins and co-chaperones
Associated Diseases	neurodegeneration
Known Drugs/Compounds	memantine
Interactions	AGING, AIFM1, ALZHEIMER, ALZHEIMER'S DISEASE, AMPK, AND
KG Connections	208 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: HSP60 — AlphaFold SEARCH Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

HSP60 (Heat Shock Protein 60)

protein · 1365 words

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Pathway Diagram

graph TD
    HSP60["HSP60"]
    Aging{"Aging"}
    HSP60 -->|"activates"| Aging
    Cardiovascular{"Cardiovascular"}
    HSP60 -->|"activates"| Cardiovascular
    PARKIN["PARKIN"]
    HSP60 -->|"activates"| PARKIN
    OPTINEURIN["OPTINEURIN"]
    HSP60 -->|"activates"| OPTINEURIN
    GRIA2["GRIA2"]
    HSP60 -->|"activates"| GRIA2
    PTEN["PTEN"]
    HSP60 -->|"activates"| PTEN
    LC3B["LC3B"]
    HSP60 -->|"activates"| LC3B
    COX4I1["COX4I1"]
    HSP60 -->|"activates"| COX4I1
    MITOCHONDRIA["MITOCHONDRIA"]
    HSP60 -->|"activates"| MITOCHONDRIA
    PINK1["PINK1"]
    HSP60 -->|"activates"| PINK1
    MAP1LC3B["MAP1LC3B"]
    HSP60 -->|"activates"| MAP1LC3B
    USP30["USP30"]
    HSP60 -->|"activates"| USP30
    XBP1["XBP1"]
    XBP1 -->|"activates"| HSP60
    MYO7A["MYO7A"]
    MYO7A -->|"activates"| HSP60
    UBIQUITIN["UBIQUITIN"]
    UBIQUITIN -->|"activates"| HSP60
    ATF3["ATF3"]
    ATF3 -->|"activates"| HSP60
    OPTN["OPTN"]
    OPTN -->|"activates"| HSP60
    PRKN["PRKN"]
    PRKN -->|"activates"| HSP60
    MITOPHAGY["MITOPHAGY"]
    MITOPHAGY -->|"activates"| HSP60
    HSPD1["HSPD1"]
    HSPD1 -->|"activates"| HSP60
    TOMM20["TOMM20"]
    TOMM20 -->|"activates"| HSP60
    FOXO3["FOXO3"]
    FOXO3 -->|"activates"| HSP60
    MAP1LC3B -->|"activates"| HSP60
    PTEN -->|"activates"| HSP60
    style HSP60 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (123)

Target	Relation	Type	Str
autophagy pathway	participates_in	pathway	0.70
Aging	activates	disease	0.65
Cardiovascular	activates	disease	0.65
Cancer	therapeutic_target	disease	0.65
Als	contributes_to	disease	0.65
Aging	contributes_to	disease	0.65
Sepsis	activates	disease	0.65
Neurodegeneration	regulates	disease	0.65
Tumor	expressed_in	disease	0.65
Cancer	expressed_in	disease	0.65
Alzheimer	activates	disease	0.65
Ms	activates	disease	0.65
Lymphoma	expressed_in	disease	0.65
Senescence	activates	disease	0.65
ALS	regulates	disease	0.65
Als	regulates	disease	0.65
Tumor	regulates	disease	0.65
P53	activates	gene	0.60
Aβ	activates	protein	0.60
TAX1BP1	activates	gene	0.60
AND	activates	gene	0.60
MITOPHAGY	activates	gene	0.60
NBR1	activates	gene	0.60
OPA1	activates	gene	0.60
RB1	activates	gene	0.60
RB1CC1	activates	gene	0.60
SQSTM1	activates	gene	0.60
MAP1LC3	activates	gene	0.60
RAS	activates	gene	0.60
Parkinson's disease	activates	disease	0.60
TP53	regulates	gene	0.60
Rb	inhibits	protein	0.60
HSP70	expressed_in	gene	0.60
HSP90	expressed_in	gene	0.60
NLRP3	expressed_in	gene	0.60
PICALM	associated_with	gene	0.60
HTRA2	activates	gene	0.60
LAMP1	activates	gene	0.60
PTEN	activates	gene	0.60
COX4I1	activates	gene	0.60
PINK1	activates	gene	0.60
MAP1LC3B	activates	gene	0.60
USP30	activates	gene	0.60
LC3	activates	gene	0.60
PIK3C3	activates	gene	0.60
P62	activates	gene	0.60
DNAJB1	expressed_in	gene	0.60
HSPD1	activates	entity	0.60
PRKN	activates	entity	0.60
TOMM20	activates	entity	0.60

Incoming (85)

Source	Relation	Type	Str
MITOCHONDRIA	inhibits	gene	0.60
COX2	activates	gene	0.60
ATG	activates	gene	0.60
DMSO	activates	gene	0.60
GABA	activates	gene	0.60
GFP	activates	gene	0.60
MAPK14	activates	gene	0.60
COX4I1	activates	entity	0.60
GRIA2	activates	entity	0.60
HSP90	activates	gene	0.60
BAX	activates	gene	0.60
AND	activates	gene	0.60
AGING	activates	gene	0.60
AMPK	activates	gene	0.60
NDP52	activates	gene	0.60
TP53	regulates	gene	0.60
PINK1	regulates	gene	0.60
LC3	activates	gene	0.60
ASC	expressed_in	gene	0.60
MITOCHONDRIA	activates	gene	0.60
LC3B	activates	gene	0.60
CANCER	expressed_in	gene	0.60
P62	regulates	gene	0.60
NF-ΚB	activates	gene	0.60
ATP	activates	gene	0.60
AIFM1	activates	gene	0.60
ATP5A1	activates	gene	0.60
CALCOCO2	activates	gene	0.60
APOPTOSIS	expressed_in	gene	0.60
PHAGOCYTOSIS	expressed_in	gene	0.60
GENES	expressed_in	gene	0.60
BCL-2	activates	gene	0.60
MYO7A	activates	gene	0.60
UBIQUITIN	activates	gene	0.60
ATF3	activates	gene	0.60
OPTN	activates	gene	0.60
PRKN	activates	gene	0.60
HSPD1	activates	gene	0.60
TOMM20	activates	gene	0.60
FOXO3	activates	gene	0.60
MAP1LC3B	activates	gene	0.60
PTEN	activates	gene	0.60
OPTINEURIN	activates	gene	0.60
DNAJC7	expressed_in	gene	0.60
BAG3	expressed_in	gene	0.60
HSPA6	expressed_in	gene	0.60
HSP70	expressed_in	gene	0.60
UBC	expressed_in	gene	0.60
HSPA1B	expressed_in	gene	0.60
HSPA1L	expressed_in	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning HSP60 in their description or question text

No additional research found