protein

CCL2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CCL2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

954Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

CCL2 is a protein involved in neurodegeneration research. Key relationships include: activates, regulates, therapeutic target. Associated with ALS, Als, Alzheimer. Connected to 253 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	CCL2
Chromosome	17q12
Function	of approximately 13 kilodaltons
Primary Expression	blood-brain barrier, spinal cord, Cerebellum, Spinal Cord
Molecular Weight	9.9 kDa
Amino Acids	99 aa
Pathways	NF-κB
GeneCards	CCL2
Human Protein Atlas	CCL2
CCR2	Primary receptor for CCL2 signaling
Microglia	Major CNS producer and responder to CCL2
Astrocytes	Astrocytic CCL2
Associated Diseases	Als, Alzheimer, Cancer, Chronic Obstructive Pulmonary Disease, dementia
Known Drugs/Compounds	metformin, METFORMIN
Interactions	ACHE, AGING, AKT, ALZHEIMER, ALZHEIMER'S DISEASE, AMPK
KG Connections	954 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (5)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    CCL2["CCL2"]
    TNF["TNF"]
    CCL2 -->|"associated with"| TNF
    CXCL10["CXCL10"]
    CCL2 -->|"associated with"| CXCL10
    Inflammation{"Inflammation"}
    CCL2 -->|"activates"| Inflammation
    Multiple_Sclerosis{"Multiple Sclerosis"}
    CCL2 -->|"activates"| Multiple_Sclerosis
    ALS{"ALS"}
    CCL2 -->|"activates"| ALS
    Autoimmune{"Autoimmune"}
    CCL2 -->|"activates"| Autoimmune
    Neurodegeneration{"Neurodegeneration"}
    CCL2 -->|"activates"| Neurodegeneration
    Cancer{"Cancer"}
    CCL2 -->|"activates"| Cancer
    Cirrhosis{"Cirrhosis"}
    CCL2 -->|"activates"| Cirrhosis
    Carcinoma{"Carcinoma"}
    CCL2 -->|"activates"| Carcinoma
    Ms{"Ms"}
    CCL2 -->|"inhibits"| Ms
    CCL2 -->|"inhibits"| Autoimmune
    LACCER["LACCER"]
    LACCER -->|"regulates"| CCL2
    ASTROCYTE["ASTROCYTE"]
    ASTROCYTE -->|"associated with"| CCL2
    AKT["AKT"]
    AKT -->|"associated with"| CCL2
    B4GALT6["B4GALT6"]
    B4GALT6 -->|"activates"| CCL2
    ASTROCYTES["ASTROCYTES"]
    ASTROCYTES -->|"activates"| CCL2
    MICROGLIA["MICROGLIA"]
    MICROGLIA -->|"activates"| CCL2
    NOTCH2["NOTCH2"]
    NOTCH2 -->|"activates"| CCL2
    DLL4["DLL4"]
    DLL4 -->|"activates"| CCL2
    PI3K["PI3K"]
    PI3K -->|"activates"| CCL2
    MTOR["MTOR"]
    MTOR -->|"activates"| CCL2
    AKT -->|"activates"| CCL2
    EGFR["EGFR"]
    EGFR -->|"activates"| CCL2
    style CCL2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (660)

Target	Relation	Type	Str
ds-db4a006ea647	provides_data_for	dataset	1.00
Inflammation	activates	disease	1.00
Als	activates	disease	1.00
Cancer	activates	disease	0.95
Neuroinflammation	activates	disease	0.95
macrophage recruitment	promotes	process	0.93
CCR2	associated_with	receptor	0.90
CCR2	activates	gene	0.90
Blood-Brain Barrier	regulates	brain_region	0.90
CCR2	inhibits	gene	0.90
CCR2	interacts_with	gene	0.90
CANCER	activates	gene	0.90
Cardiac Inflammation	involved_in	process	0.88
MICROGLIA	activates	cell_type	0.86
Microglia Recruitment	mediates	process	0.85
Microglia Activation	mediates	process	0.85
Neurodegeneration	activates	disease	0.85
Chronic Obstructive Pulmonary Disease	associated_with	disease	0.85
Monocyte Adherence	promotes	process	0.85
Neuroinflammation	involved_in	process	0.85
Macrophage Infiltration	contributes_to	process	0.85
Liver Cirrhosis	risk_factor_for	disease	0.80
Immune Cell Infiltration	mediates	process	0.80
CCR2	regulates	gene	0.80
CCR2	targets	gene	0.80
macrophages	expressed_in	cell_type	0.80
NEUROINFLAMMATION	activates	gene	0.80
AKT	activates	gene	0.80
Infection	activates	disease	0.75
Monocyte Infiltration	promotes	process	0.75
Inflammation	associated_with	disease	0.75
Tumor	activates	disease	0.75
Neuroinflammation	causes	disease	0.75
Multiple Sclerosis	activates	disease	0.75
Inflammation	causes	disease	0.75
CXCL10	expressed_in	gene	0.70
MACROPHAGE	expresses	cell_type	0.70
TNF	mediates	gene	0.70
MICROGLIA	mediates	cell_type	0.70
SQSTM1	activates	gene	0.70
MAPT	markers	gene	0.70
PDGF	activates	gene	0.70
TAU	activates	gene	0.70
EGF	regulates	gene	0.70
NFKB	activates	gene	0.70
CREB	regulates	gene	0.70
CXCL10	markers	gene	0.70
P2RX7	expresses	gene	0.70
CX3CR1	associated_with	gene	0.70
FOXP3	expresses	gene	0.70

Incoming (294)

Source	Relation	Type	Str
ds-db4a006ea647	data_in	dataset	1.00
NF-κB signaling pathway	upstream_of	pathway	0.95
NF-κB p65	regulates	protein	0.93
Astrocytes	product_of	cell_type	0.90
Pulmonary Vascular Endothelial Cell Senescence	upregulates	process	0.90
LacCer	upregulates	compound	0.90
Lactosylceramide	regulates	compound	0.90
TNF	activates	gene	0.90
INFLAMMATION	activates	gene	0.90
Lactosylceramide	upregulates	compound	0.85
Translation Initiation Inhibition	downregulates	mechanism	0.85
NOTCH2	upregulates	gene	0.85
KCNK2	downregulates	gene	0.80
NEURODEGENERATION	activates	gene	0.80
PI3K	activates	gene	0.80
ATG7	interacts_with	gene	0.70
ASTROCYTE	inhibits	cell_type	0.70
APP	mediates	gene	0.70
CAT	biomarker_for	gene	0.70
ACHE	inhibits	gene	0.70
ACHE	activates	gene	0.70
INFLAMMATION	causes	gene	0.70
INFLAMMATION	implicated_in	gene	0.70
ATG5	activates	gene	0.70
ROS	activates	gene	0.70
AMPK	activates	gene	0.70
GLIOBLASTOMA	associated_with	disease	0.65
STROKE	treats	disease	0.65
STROKE	exacerbates	disease	0.65
LRP1	regulates	gene	0.65
MACROPHAGES	targets	cell_type	0.65
MACROPHAGES	produces	cell_type	0.65
MAPK	regulates	gene	0.65
APOPTOSIS	causes	phenotype	0.65
LACCER	regulates	protein	0.64
ACHE	regulates	gene	0.60
PARKINSON	regulates	gene	0.60
NEUROINFLAMMATION	inhibits	gene	0.60
NR4A2	activates	gene	0.60
NCOR1	interacts_with	gene	0.60
NR4A1	activates	gene	0.60
ASTROCYTE	expresses	cell_type	0.60
ACHE	targets	gene	0.60
CXCL8	expressed_in	gene	0.60
MYD88	inhibits	gene	0.60
TNF-Α	inhibits	gene	0.60
BMAL1	expressed_in	gene	0.60
CLOCK	expressed_in	gene	0.60
MTOR	activates	gene	0.60
AKT	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CCL2 in their description or question text

No additional research found