gene

JAK1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about JAK1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

354Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

JAK1 is a gene implicated in neurodegeneration research. Key relationships include: activates, inhibits, biomarker for. Associated with ALS, Aging, Als. Connected to 188 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	JAK1
Full Name	Janus Kinase 1
Chromosome	1p31.3
Function	JAK1 encodes Janus kinase 1, a non-receptor tyrosine kinase that mediates signaling for type I and type II cytokine receptors.
Primary Expression	most cell types
Pathways	JAK-STAT pathway
UniProt ID	[P23458](https://www.uniprot.org/uniprot/P23458)
Ensembl ID	ENSG00000162433
OMIM	147795
GeneCards	JAK1
Human Protein Atlas	JAK1
Associated Diseases	Alzheimer, Alzheimer's disease, disease, Huntington, Huntington's disease
Known Drugs/Compounds	Ponicidin, quercetin
Interactions	AGING, AKT, AND, APOPTOSIS, ASC, ATG5
KG Connections	354 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

JAK1 — Janus Kinase 1

gene · 539 words

→

JAK1 Protein — Janus Kinase 1

protein · 565 words

→

Pathway Diagram

graph TD
    JAK1["JAK1"] -->|"activates"| STAT3["STAT3"]
    JAK1["JAK1"] -.->|"inhibits"| Aging["Aging"]
    JAK1["JAK1"] -->|"activates"| Ms["Ms"]
    JAK1["JAK1"] -.->|"inhibits"| Inflammation["Inflammation"]
    JAK1["JAK1"] -->|"regulates"| Inflammation_1["Inflammation"]
    JAK1["JAK1"] -->|"biomarker for"| Als["Als"]
    LIFR["LIFR"] -->|"activates"| JAK1["JAK1"]
    GP130["GP130"] -->|"activates"| JAK1["JAK1"]
    HIF1A["HIF1A"] -->|"activates"| JAK1["JAK1"]
    IL6["IL6"] -.->|"inhibits"| JAK1["JAK1"]
    style JAK1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (223)

Target	Relation	Type	Str
Als	activates	disease	1.00
Inflammation	activates	disease	1.00
JAK1/STAT1/3 axis	part_of	pathway	0.95
STAT3	activates	protein	0.90
STAT1	phosphorylates	protein	0.85
Inflammation	inhibits	disease	0.85
Tumor	activates	disease	0.85
STAT3	phosphorylates	gene	0.80
Carcinoma	activates	disease	0.75
Cancer	therapeutic_target	disease	0.75
Autoimmune	activates	disease	0.75
Lupus	activates	disease	0.75
Metastasis	activates	pathway	0.70
JAK-STAT signaling	participates_in	pathway	0.70
MAPK signaling	participates_in	pathway	0.70
Infection	activates	disease	0.65
Ischemia	activates	disease	0.65
Lymphoma	activates	disease	0.65
Alzheimer	associated_with	disease	0.65
ALS	biomarker_for	disease	0.65
Huntington	associated_with	disease	0.65
Diabetes	activates	disease	0.65
Psoriasis	activates	disease	0.65
Als	contributes_to	disease	0.65
Psoriasis	contributes_to	disease	0.65
Cancer	inhibits	disease	0.65
Ischemia	inhibits	disease	0.65
Ferroptosis	activates	disease	0.65
Als	expressed_in	disease	0.65
Ms	expressed_in	disease	0.65
Tumor	regulates	disease	0.65
Autoimmune	inhibits	disease	0.65
Ms	biomarker_for	disease	0.65
Fibrosis	regulates	disease	0.65
Neuroinflammation	inhibits	disease	0.65
Parkinson	inhibits	disease	0.65
Tumor	therapeutic_target	disease	0.65
Breast Cancer	therapeutic_target	disease	0.65
Inflammation	regulates	disease	0.65
Als	biomarker_for	disease	0.65
Neuroinflammation	activates	disease	0.65
Leukemia	inhibits	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Atherosclerosis	regulates	disease	0.65
Huntington	therapeutic_target	disease	0.65
Colorectal Cancer	expressed_in	disease	0.65
Cancer	expressed_in	disease	0.65
Aging	inhibits	disease	0.65
Ms	activates	disease	0.65
Diabetes	expressed_in	disease	0.65

Incoming (131)

Source	Relation	Type	Str
IL6	activates	gene	0.90
INFLAMMATION	activates	gene	0.90
RIPK1	interacts_with	gene	0.88
NLRP3	interacts_with	gene	0.85
Ponicidin	inhibits	compound	0.80
LIFR	activates	protein	0.80
STAT1	activates	gene	0.80
JAK	inhibits	gene	0.70
CANCER	therapeutic_target	gene	0.70
GP130	activates	protein	0.64
STAT1	expressed_in	gene	0.60
STAT6	expressed_in	gene	0.60
CD4	activates	gene	0.60
TNF	contributes_to	gene	0.60
PI3K	contributes_to	gene	0.60
CD14	contributes_to	gene	0.60
CXCL10	activates	gene	0.60
AKT	contributes_to	gene	0.60
CXCR3	contributes_to	gene	0.60
MCL1	expressed_in	gene	0.60
SOCS3	regulates	gene	0.60
STAT3	expressed_in	gene	0.60
JAK2	regulates	gene	0.60
BCL2	expressed_in	gene	0.60
STAT3	activates	gene	0.60
BAX	activates	gene	0.60
FAS	activates	gene	0.60
VEGFA	activates	gene	0.60
CHI3L1	activates	gene	0.60
JAK	associated_with	gene	0.60
IL13RA1	regulates	gene	0.60
GENES	regulates	gene	0.60
CYTOKINES	expressed_in	gene	0.60
AND	associated_with	gene	0.60
CYTOKINES	contributes_to	gene	0.60
ASTROCYTE	therapeutic_target	gene	0.60
AND	inhibits	gene	0.60
JAK	activates	gene	0.60
TNFRSF19	biomarker_for	gene	0.60
INFLAMMATION	regulates	gene	0.60
RNA	biomarker_for	gene	0.60
AND	regulates	gene	0.60
COX2	inhibits	gene	0.60
JAK3	expressed_in	gene	0.60
GAIN	expressed_in	gene	0.60
CXCL2	biomarker_for	gene	0.60
CSF2	biomarker_for	gene	0.60
STAT3	regulates	gene	0.60
MMP9	biomarker_for	gene	0.60
JAK2	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning JAK1 in their description or question text

No additional research found