gene

S100A8

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about S100A8: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

299Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

S100A8 is a gene implicated in neurodegeneration research. Key relationships include: regulates, associated with, inhibits. Associated with ALS, Als, Atherosclerosis. Connected to 151 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	S100A8
Full Name	S100 Calcium Binding Protein A8
Chromosome	1q21.3
Protein Family	S100 calcium-binding protein family
Function	S100A8 and the S100A8/A9 complex (calprotectin) have several critical functions
Primary Expression	specific cell types and pathological conditions
Molecular Weight	10.8 kDa
Amino Acids	93 aa
Exons	3
Pathways	NF-κB, MAPK signaling
GeneCards	S100A8
Human Protein Atlas	S100A8
N-terminal hinge region	Low complexity region involved in protein interactions
EF-hand I (pseudo)	Non-functional calcium-binding site at N-terminus
EF-hand II (canonical)	Functional calcium-binding site at C-terminus
Associated Diseases	Alzheimer, Cancer, Heart Failure, Lupus, Ms, Sepsis
Known Drugs/Compounds	GW201
Interactions	ACE2, Actin, AGING, AMPK, AND, APOPTOSIS
KG Connections	299 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    S100A8["S100A8"]
    S100A8 -->|"inhibits"| Ms["Ms"]
    S100A8 -->|"regulates"| Als["Als"]
    S100A8 -->|"interacts"| Inflammation["Inflammation"]
    S100A8 -->|"activates"| Cancer["Cancer"]
    S100A8 -->|"inhibits"| Spinal_Cord_Injury["Spinal Cord Injury"]
    S100A8 -->|"regulates"| ALS["ALS"]
    S100A8 -->|"interacts"| TLR4["TLR4"]
    CSF2["CSF2"] -->|"regulates"| S100A8
    NAMPT["NAMPT"] -->|"regulates"| S100A8
    FGF2["FGF2"] -->|"regulates"| S100A8
    CXCL10["CXCL10"] -->|"regulates"| S100A8
    HSPA1A["HSPA1A"] -->|"regulates"| S100A8
    FGF8["FGF8"] -->|"regulates"| S100A8
    TLR4 -->|"regulates"| S100A8
    ISG15["ISG15"] -->|"regulates"| S100A8
    STAT1["STAT1"] -->|"regulates"| S100A8
    CSF2RA["CSF2RA"] -->|"regulates"| S100A8

Outgoing (188)

Target	Relation	Type	Str
Th17/Th22 Pathway	involved_in	pathway	0.85
AGING	upregulates	process	0.80
Tumor	associated_with	disease	0.75
inflammatory response	promotes	process	0.75
ALS	expressed_in	disease	0.65
Ms	expressed_in	disease	0.65
ALS	regulates	disease	0.65
Cancer	associated_with	disease	0.65
Heart Failure	causes	disease	0.65
Myocardial Infarction	biomarker_for	disease	0.65
Aging	activates	disease	0.65
Fibrosis	activates	disease	0.65
Inflammation	inhibits	disease	0.65
Sepsis	associated_with	disease	0.65
Inflammation	interacts_with	disease	0.65
Neuroinflammation	inhibits	disease	0.65
Als	activates	disease	0.65
Traumatic Brain Injury	inhibits	disease	0.65
ALS	activates	disease	0.65
Als	regulates	disease	0.65
Ms	inhibits	disease	0.65
Ms	activates	disease	0.65
Multiple Sclerosis	interacts_with	disease	0.65
Fibrosis	inhibits	disease	0.65
Als	inhibits	disease	0.65
Obesity	inhibits	disease	0.65
Stroke	associated_with	disease	0.65
Als	interacts_with	disease	0.65
Als	expressed_in	disease	0.65
Infection	interacts_with	disease	0.65
Atherosclerosis	expressed_in	disease	0.65
Inflammation	expressed_in	disease	0.65
Neuroinflammation	therapeutic_target	disease	0.65
Alzheimer	associated_with	disease	0.65
Lupus	associated_with	disease	0.65
Cancer	activates	disease	0.65
Inflammation	therapeutic_target	disease	0.65
Spinal Cord Injury	inhibits	disease	0.65
Als	biomarker_for	disease	0.65
Ms	associated_with	disease	0.65
TLR4	interacts_with	protein	0.64
HO-1	inhibits	gene	0.60
BRAIN INJURY	inhibits	gene	0.60
NEUROINFLAMMATION	inhibits	gene	0.60
INFLAMMATION	expressed_in	gene	0.60
Toll-Like Receptor	associated_with	pathway	0.60
Phagocytosis	associated_with	pathway	0.60
Apoptosis	associated_with	pathway	0.60
Autophagy	associated_with	pathway	0.60
Oxidative Stress	activates	pathway	0.60

Incoming (111)

Source	Relation	Type	Str
GW201	modulates	compound	0.85
GW201	downregulates	compound	0.75
MMP9	associated_with	gene	0.60
BAX	activates	gene	0.60
P38	regulates	gene	0.60
PI3K	regulates	gene	0.60
TLR4	inhibits	gene	0.60
MMP2/MMP9	inhibits	gene	0.60
IFNG	expressed_in	gene	0.60
BECN1	associated_with	gene	0.60
ATG5	associated_with	gene	0.60
FIP200	associated_with	gene	0.60
RB1	associated_with	gene	0.60
IFNG	associated_with	gene	0.60
LC3	associated_with	gene	0.60
ATG14	associated_with	gene	0.60
MAP1LC3A	associated_with	gene	0.60
CASP1	associated_with	gene	0.60
TNF	associated_with	gene	0.60
TLR4	associated_with	gene	0.60
S100A9	inhibits	gene	0.60
NLRP3	inhibits	gene	0.60
IL18	inhibits	gene	0.60
NLRP1	inhibits	gene	0.60
IL1B	inhibits	gene	0.60
S100A9	regulates	gene	0.60
AND	therapeutic_target	gene	0.60
GENES	associated_with	gene	0.60
ROS	activates	gene	0.60
AMPK	inhibits	gene	0.60
ALZHEIMER'S DISEASE	associated_with	gene	0.60
STROKE	associated_with	gene	0.60
AND	associated_with	gene	0.60
CLDN1	inhibits	gene	0.60
CD31	expressed_in	gene	0.60
GENES	inhibits	gene	0.60
GENES	activates	gene	0.60
NF-ΚB	interacts_with	gene	0.60
EPOR	regulates	gene	0.60
EPO	regulates	gene	0.60
NF-ΚB	inhibits	gene	0.60
TNF-Α	inhibits	gene	0.60
GENES	regulates	gene	0.60
GENES	expressed_in	gene	0.60
INFLAMMATION	expressed_in	gene	0.60
MTDNA	activates	gene	0.60
S100A9	associated_with	gene	0.60
AGING	activates	gene	0.60
NAMPT	regulates	gene	0.60
FGF2	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning S100A8 in their description or question text

No additional research found