protein 841 words KG: COX20PROTEIN
Contents

COX20 Protein (Cytochrome C Oxidase Assembly Factor)

🔬 Protein Info
Gene SymbolCOX20
Full NameCytochrome c oxidase assembly factor 20
AliasesCytochrome C Oxidase Assembly Factor
Chromosome1p31.3
Functionis a nuclear-encoded mitochondrial protein that plays an indispensable role in the biogenesis of cytochrome c oxidase (Complex IV), the terminal enzyme of the mitochondrial electron transport chain.
Primary ExpressionHigh in cerebellum, inner ear, heart, skeletal muscle
Subcellular Localization**Mitochondrial inner membrane**: Integral membrane protein
Molecular Weight22 kDa
Amino Acids198 aa
UniProt IDQ9Y4Y6
NCBI Gene ID91574
Ensembl IDENSG00000173391
GeneCardsCOX20
Human Protein AtlasCOX20
N-terminal domainProtrudes into the mitochondrial matrix
Associated Diseasesneurodegeneration
DatabasesGeneCardsHPASTRING

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Knowledge Graph

Related Hypotheses (4)

Matrix Stiffness Normalization via Targeted Lysyl Oxidase In
Score: 0.71
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62

Related Analyses (7)

Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · completed

Related Experiments (13)

Animal Model Comparison for Neurodegenerative Disease Therap
clinical · proposed · Score: 0.40
Endocannabinoid System Dysfunction Validation in Parkinson's
clinical · proposed · Score: 0.40
Glymphatic-Circadian Axis Enhancement Therapy for Parkinson'
clinical · proposed · Score: 0.40
Cytochrome Therapeutics
clinical · proposed · Score: 0.40
Gut Microbiome-Derived Metabolites in Alpha-Synuclein Propag
clinical · proposed · Score: 0.40

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in

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