gene

MTDNA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MTDNA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1156Connections

2Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

MTDNA is a gene implicated in neurodegeneration research. Key relationships include: activates, associated with, inhibits. Associated with ALS, Aging, Als. Connected to 733 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	MTDNA
Primary Expression	Spinal Cord
Pathways	Mitophagy, Nf-Κb, Oxidative Stress, Apoptosis, Autophagy
GeneCards	MTDNA
Human Protein Atlas	MTDNA
Associated Diseases	Aging, Als, Alzheimer, Autism, Autoimmune
Interactions	Actin, AGING, AIM2, AKT, ALS, ALZHEIMER
KG Connections	1121 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Pathway Diagram

graph TD
    MTDNA["MTDNA"] -->|"activates"| Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
    MTDNA["MTDNA"] -->|"activates"| Als["Als"]
    MTDNA["MTDNA"] -->|"activates"| Inflammation["Inflammation"]
    MTDNA["MTDNA"] -->|"activates"| Aging["Aging"]
    MTDNA["MTDNA"] -->|"activates"| Ms["Ms"]
    MTDNA["MTDNA"] -->|"associated"| Carcinoma["Carcinoma"]
    TDP43["TDP43"] -->|"causes"| MTDNA["MTDNA"]
    STING["STING"] -->|"activates"| MTDNA["MTDNA"]
    CGAS["CGAS"] -->|"activates"| MTDNA["MTDNA"]
    GPX4["GPX4"] -->|"associated"| MTDNA["MTDNA"]
    style MTDNA fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (708)

Target	Relation	Type	Str
DNA	activates	gene	1.00
CGAS-STING	activates	gene	1.00
STING	activates	gene	1.00
Oxidative Stress	activates	pathway	1.00
MITOCHONDRIA	activates	gene	1.00
Mitochondrial Function	activates	pathway	1.00
Mitophagy	activates	pathway	1.00
DNA	associated_with	gene	1.00
Inflammation	activates	disease	1.00
Als	activates	disease	1.00
MITOCHONDRIA	associated_with	gene	1.00
Autophagy	activates	pathway	1.00
Neuroinflammation	activates	disease	0.95
Cancer	therapeutic_target	disease	0.95
Oxidative Phosphorylation	associated_with	process	0.95
Neurodegeneration	activates	disease	0.95
13 PROTEINS	encodes	protein	0.95
Oxidative Phosphorylation	involved_in	process	0.95
Inflammation	inhibits	disease	0.95
CGAS	activates	protein	0.94
Mitochondrial Disorders	associated_with	disease	0.90
Mitochondrial Disorders	biomarker_for	disease	0.90
mitochondrial proteome	associated_with	protein	0.90
mitochondrial respiration	regulates	process	0.90
DNA	inhibits	gene	0.90
IL-6	activates	protein	0.88
NF-κB	activates	protein	0.88
Cancer	activates	disease	0.85
Aging	activates	disease	0.85
Senescence	activates	disease	0.85
Neurodegeneration	associated_with	disease	0.85
Ischemia	inhibits	disease	0.85
cGAS-STING Pathway	activates	pathway	0.85
Parkinson	activates	disease	0.85
Neuroinflammation	promotes	process	0.85
Als	associated_with	disease	0.85
Als	therapeutic_target	disease	0.85
Alzheimer	activates	disease	0.85
Als	inhibits	disease	0.85
Mitochondrial Proteome	contributes_to	protein	0.80
Neuroinflammation	associated_with	process	0.80
NLRP3	activates	protein	0.80
Mitochondrial Function	involved_in	process	0.80
Mitochondrial Function	regulates	process	0.80
Nf-Κb	activates	pathway	0.80
Oxidative Stress	associated_with	pathway	0.80
AGING	activates	gene	0.80
GENES	activates	gene	0.80
Oxidative Phosphorylation	causes	pathway	0.80
MITOCHONDRIAL DYSFUNCTION	associated_with	gene	0.80

Incoming (448)

Source	Relation	Type	Str
OXIDATIVE STRESS	activates	gene	1.00
PINK1	activates	gene	1.00
MITOCHONDRIAL DNA	activates	gene	1.00
MITOCHONDRIAL DNA	associated_with	gene	1.00
INFLAMMATION	activates	gene	1.00
ROS	activates	gene	1.00
MITOCHONDRIAL DYSFUNCTION	activates	gene	1.00
CGAS	activates	gene	1.00
MITOPHAGY	activates	gene	1.00
MITOCHONDRIAL DNA	causes	gene	1.00
DNA	activates	gene	1.00
GENES	activates	gene	1.00
oxidative stress	causes	process	0.90
TFAM	regulates	protein	0.90
mtROS	associated_with	process	0.90
zalcitabine	causes	drug	0.90
TFAM	binds_to	protein	0.90
Mtros	downregulates	compound	0.90
NEURODEGENERATIVE DISEASES	activates	gene	0.90
NEURODEGENERATION	activates	gene	0.90
APOPTOSIS	activates	gene	0.90
TFAM Knockdown	downregulates	process	0.85
POLG	involved_in	gene	0.85
Mitochondrial Fission	causes	process	0.85
POLG	regulates	protein	0.80
CGAS	binds	gene	0.80
MITOCHONDRIAL_DYSFUNCTION	increases	biological_process	0.80
IMPAIRED_MITOPHAGY	increases	biological_process	0.80
VDAC	mediates	protein	0.80
AUTOPHAGY	activates	gene	0.80
PARKIN	activates	gene	0.80
NEUROINFLAMMATION	activates	gene	0.80
CANCER	therapeutic_target	gene	0.80
INFLAMMATION	inhibits	gene	0.80
NEURODEGENERATION	associated_with	gene	0.80
NF-ΚB	activates	gene	0.80
GENES	associated_with	gene	0.80
CYTOKINES	activates	gene	0.80
OXIDATIVE STRESS	inhibits	gene	0.80
ATM	modulates	protein	0.75
TDP43	causes	protein	0.72
P62	activates	gene	0.70
NLRP3	activates	gene	0.70
PYROPTOSIS	activates	gene	0.70
IRF3	inhibits	gene	0.70
CGAS-STING	activates	gene	0.70
PARKINSON'S DISEASE	activates	gene	0.70
GSDMD	activates	gene	0.70
epigenetic modification	regulates	process	0.70
DNA	inhibits	gene	0.70

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Calcium-Dysregulated mPTP Opening as an Alternative mtDNA Re	0.804	neurodegeneration	What are the mechanisms by which gut mic
Severely Depleted mtDNA and Impaired OXPHOS Defines Senescen	0.520	neurodegeneration	How can senescent microglia be molecular

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning MTDNA in their description or question text

No additional research found