gene

FER

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about FER: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

209Connections

30Hypotheses

0Analyses

50Outgoing

50Incoming

5Experiments

0Debates

Summary

FER is a gene implicated in neurodegeneration research. Key relationships include: activates, inhibits, treats. Associated with ALS, Als, Arthritis. Connected to 131 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	FER
Full Name	FER Proto-Oncogene, Tyrosine Kinase
Chromosome	5q31.2
Protein Type	Receptor
Function	The FER gene encodes a non-receptor tyrosine kinase (Fer) that belongs to the FPS/FES family of tyrosine kinases.
Primary Expression	the brain and plays important roles in neuronal signaling, synaptic function, and cell adhesion[@fer2000]
Pathways	Ferroptosis, Oxidative Stress
UniProt ID	[P16591](https://www.uniprot.org/uniprot/P16591)
Ensembl ID	ENSG00000151422
GeneCards	FER
Human Protein Atlas	FER
Postsynaptic density	Fer localizes to PSDs and phosphorylates PSD-95, affecting synaptic scaffolding
Receptor tyrosine kinases	Fer interacts with and regulates signaling from neurotrophin receptors
Synaptic plasticity	Fer activity modulates long-term potentiation (LTP) and long-term depression (LTD)[@yamada2019]
Associated Diseases	Stroke
Interactions	ACSL4, AKT, ALOX12, ALOX15, ALOX5, ALOXE3
KG Connections	209 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (6)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

flowchart TD
    FER["FER"] -->|"activates"| Cancer["Cancer"]
    FER["FER"] -->|"activates"| Als["Als"]
    FER["FER"] -->|"activates"| Arthritis["Arthritis"]
    FER["FER"] -->|"associated with"| Stroke["Stroke"]
    FER["FER"] -->|"activates"| Parkinson["Parkinson"]
    FER["FER"] -->|"biomarker for"| Cardiac["Cardiac"]
    FER["FER"] -->|"therapeutic target"| Ms["Ms"]
    FER["FER"] -->|"biomarker for"| Inflammation["Inflammation"]
    FER["FER"] -->|"activates"| ALS["ALS"]
    FER["FER"] -->|"activates"| Ferroptosis["Ferroptosis"]
    FER["FER"] -.->|"inhibits"| Ferroptosis["Ferroptosis"]
    FER["FER"] -->|"activates"| NFE2L2["NFE2L2"]
    style FER fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style Cancer fill:#ef5350,stroke:#333,color:#e0e0e0
    style Als fill:#ef5350,stroke:#333,color:#e0e0e0
    style Arthritis fill:#ef5350,stroke:#333,color:#e0e0e0
    style Stroke fill:#ef5350,stroke:#333,color:#e0e0e0
    style Parkinson fill:#ef5350,stroke:#333,color:#e0e0e0
    style Cardiac fill:#ef5350,stroke:#333,color:#e0e0e0
    style Ms fill:#ef5350,stroke:#333,color:#e0e0e0
    style Inflammation fill:#ef5350,stroke:#333,color:#e0e0e0
    style ALS fill:#ef5350,stroke:#333,color:#e0e0e0
    style Ferroptosis fill:#1b5e20,stroke:#333,color:#e0e0e0
    style NFE2L2 fill:#4a1a6b,stroke:#333,color:#e0e0e0

Outgoing (110)

Target	Relation	Type	Str
Ferroptosis	activates	pathway	0.90
Cancer	activates	disease	0.85
Ferroptosis	inhibits	pathway	0.80
Tumor	inhibits	disease	0.75
Inflammation	activates	disease	0.75
Autophagy	activates	pathway	0.70
Apoptosis	activates	pathway	0.70
Ferroptosis	treats	pathway	0.70
Osteoarthritis	activates	disease	0.65
Tumor	activates	disease	0.65
Pulmonary Fibrosis	activates	disease	0.65
Fibrosis	activates	disease	0.65
Breast Cancer	activates	disease	0.65
Liver Cancer	activates	disease	0.65
Lung Cancer	activates	disease	0.65
Arthritis	activates	disease	0.65
Als	biomarker_for	disease	0.65
Sepsis	activates	disease	0.65
Ms	activates	disease	0.65
Als	regulates	disease	0.65
ALS	activates	disease	0.65
Als	activates	disease	0.65
Fibrosis	treats	disease	0.65
Inflammation	treats	disease	0.65
Stroke	associated_with	disease	0.65
ALS	regulates	disease	0.65
Parkinson	activates	disease	0.65
Colorectal Cancer	activates	disease	0.65
Cardiac	biomarker_for	disease	0.65
Als	inhibits	disease	0.65
Ms	therapeutic_target	disease	0.65
Inflammation	biomarker_for	disease	0.65
Oxidative Stress	treats	pathway	0.60
Nf-Κb	activates	pathway	0.60
MITOCHONDRIAL DYSFUNCTION	inhibits	gene	0.60
ATP	activates	gene	0.60
Lipid Metabolism	contributes_to	pathway	0.60
Akt	activates	pathway	0.60
Pi3K	activates	pathway	0.60
BCL-2	activates	gene	0.60
NEURON	regulates	gene	0.60
AND	activates	gene	0.60
APOPTOSIS	activates	gene	0.60
PARKINSON'S DISEASE	activates	gene	0.60
OXIDATIVE STRESS	activates	gene	0.60
PARKINSON	activates	gene	0.60
Oxidative Stress	activates	pathway	0.60
RNA	associated_with	gene	0.60
Mtor	activates	pathway	0.60
Mitophagy	regulates	pathway	0.60

Incoming (99)

Source	Relation	Type	Str
FERROPTOSIS	activates	gene	0.90
CANCER	activates	gene	0.80
ROS	activates	gene	0.80
FERROPTOSIS	inhibits	gene	0.80
P53	activates	gene	0.70
APOPTOSIS	activates	gene	0.70
TNF-Α	activates	gene	0.70
ROS	inhibits	gene	0.70
INFLAMMATION	activates	gene	0.70
SLC7A11	activates	gene	0.70
TNF	activates	gene	0.70
FERROPTOSIS	treats	gene	0.70
GPX4	activates	gene	0.70
GPX4	inhibits	gene	0.70
P62	activates	gene	0.60
PARKINSON	activates	gene	0.60
MITOCHONDRIA	activates	gene	0.60
NEUROTOXICITY	activates	gene	0.60
PARKINSON'S DISEASE	activates	gene	0.60
GENES	expressed_in	gene	0.60
MMP3	activates	gene	0.60
SOX9	activates	gene	0.60
SLC7A11	therapeutic_target	gene	0.60
MMP1	activates	gene	0.60
GPX4	therapeutic_target	gene	0.60
NCOA4	expressed_in	gene	0.60
NRF2	inhibits	gene	0.60
CHAC1	activates	gene	0.60
AUTOPHAGY	activates	gene	0.60
IL-6	activates	gene	0.60
GENES	activates	gene	0.60
RNA	associated_with	gene	0.60
AND	inhibits	gene	0.60
GSH	inhibits	gene	0.60
OXIDATIVE STRESS	activates	gene	0.60
COX2	expressed_in	gene	0.60
SPR	activates	gene	0.60
BLOOD-BRAIN BARRIER DYSFUNCTION	activates	gene	0.60
AKT	activates	gene	0.60
APOPTOSIS	associated_with	gene	0.60
FERROPTOSIS	regulates	gene	0.60
AND	activates	gene	0.60
HIF-1Α	activates	gene	0.60
BCL-2	interacts_with	gene	0.60
HIF	activates	gene	0.60
AND	contributes_to	gene	0.60
MITOCHONDRIAL DYSFUNCTION	regulates	gene	0.60
ERBB2	activates	gene	0.60
ALOXE3	activates	gene	0.60
NCOA4	regulates	gene	0.60

Targeting Hypotheses (30)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
ACSL4-Driven Ferroptotic Priming in Disease-Associated Micro	0.847	Alzheimer's Disease	Cell type vulnerability in Alzheimers Di
miR-155/Interferon-gamma Feedback Loop as a Reversible Molec	0.843	neurodegeneration	How do different microglial subtypes (DA
Sequential Iron Chelation (Deferoxamine) and GPX4 Restoratio	0.838	neurodegeneration	View
SIRT1 Activation Couples Mitochondrial Biogenesis to Ferropt	0.824	neurodegeneration	View
SLC7A11 System Activation Restores Cystine Uptake and GSH Sy	0.812	neurodegeneration	View

Targeting the Mechanistic Link Between AQP4 Dysfunction and	0.803	neurodegeneration	View
ACSL4-Ferroptotic Priming in Stressed Oligodendrocytes Drive	0.801	Alzheimer's Disease	Cell type vulnerability in Alzheimers Di
40 Hz Gamma Entrainment Gates ACSL4-Mediated Ferroptotic Pri	0.801	Alzheimer's Disease	Cell type vulnerability in Alzheimers Di
pH-Sensitive Bispecific Antibody Targeting Transferrin Recep	0.800	neurodegeneration	Blood-brain barrier antibody transport m
LPCAT3-Mediated Lands Cycle Remodeling as the Primary Ferrop	0.779	Alzheimer's Disease	Cell type vulnerability in Alzheimers Di
ACSL4-Driven Ferroptotic Priming in Disease-Associated Oligo	0.779	Alzheimer's Disease	Cell type vulnerability in Alzheimers Di
ALOX15-Driven Enzymatic Ferroptosis in AD Oligodendrocytes v	0.777	Alzheimer's Disease	Cell type vulnerability in Alzheimers Di
LPCAT3-Mediated Lands Cycle Amplification of Ferroptotic Sub	0.776	Alzheimer's Disease	Cell type vulnerability in Alzheimers Di
LPCAT3-Mediated Lands Cycle Amplification of Ferroptotic Vul	0.770	Alzheimer's Disease	Cell type vulnerability in Alzheimers Di
Iron-driven lipid peroxidation and GPX4 failure create a fer	0.750	neurodegeneration	What mechanisms drive the self-amplifyin
Seed-Proximal Asymmetric Duplex Stability Confers lncRNA-002	0.733	molecular neurobiology	View
Differential Complement Regulator Expression on Synaptic Mem	0.725	synaptic biology	What determines the selectivity of compl
Magnetosonic-Triggered Transferrin Receptor Clustering	0.719	neurodegeneration	Blood-brain barrier transport mechanisms
Ferroptosis Inhibition for α-Synuclein Neuroprotection	0.705	neurodegeneration	Gene expression changes in aging mouse b
Microglial Efferocytosis Enhancement via GPR32 Superagonists	0.704	neurodegeneration	Neuroinflammation resolution mechanisms
Mitochondrial Transfer Pathway Enhancement	0.695	neurodegeneration	Astrocyte reactivity subtypes in neurode
CX43 hemichannel engineering enables size-selective mitochon	0.686	neurodegeneration	Mitochondrial transfer between astrocyte
Differential Ubiquitin Chain Topology Creates 'Invisible' Su	0.682	neurodegeneration	How do pathological stress granules in n
GPX4 Selenopeptide Mimetics as Neuroprotective Ferroptosis B	0.680	-	Ferroptosis in ALS and motor neuron dise
Physiological SCFAs may confer indirect anti-synuclein benef	0.670	neurodegeneration	Do physiological concentrations of SCFAs
GAP43-mediated tunneling nanotube stabilization enhances neu	0.666	neurodegeneration	Mitochondrial transfer between astrocyte
Biorhythmic Interference via Controlled Sleep Oscillations	0.661	neurodegeneration	Microglia-astrocyte crosstalk amplificat
Chronic cGAS/STING Hyperactivation Drives Progressive Neurod	0.660	neuroinflammation	How does chronic cGAS/STING activation d
Mitochondrial Calcium Buffering Enhancement via MCU Modulati	0.650	neurodegeneration	Selective vulnerability of entorhinal co
Heterogeneous astrocyte activation states differentially imp	0.640	Alzheimer's disease	SEA-AD Single-Cell Analysis: Cell-Type V

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (5)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Model	Status	Est. Cost
SAHA@LIPO-ANG2 therapeutic efficacy in 5xFAD mice	validation	Alzheimer's disease	0.900	5xFAD transgenic mice	proposed	N/A
Transcriptomic profiling and differential expression analysis	exploratory	Alzheimer's disease	0.900	1-month-old APP/PS1 mice cereb	proposed	N/A
Irisin effects on osteogenic differentiation in mesenchymal stem cells	exploratory	bone fracture	0.900	mouse bone mesenchymal stem ce	proposed	N/A
SIRPα modulation in mouse models of Alzheimer's disease	validation	Alzheimer's disease	0.900	mouse models of Alzheimer's di	proposed	N/A
Microglial SIRPα expression in human Alzheimer's disease tissue	exploratory	Alzheimer's disease	0.800	human brain tissue	proposed	N/A

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Transcriptomic cytoarchitecture reveals principles of human neocortex organizati [PMID:37824655]	Jorstad NL, Close J, Johansen N, Yanny A	Science	2023	186
FAK/SRC-JNK axis promotes ferroptosis via upregulating ACSL4 expression. [PMID:41862445]	Qin J, Ma S, Wang J, Huang S, Luan J, He	Cell death & disease	2026	0
Quercetin attenuates ox-LDL-induced endothelial injury by regulating ferroptosis [PMID:41902795]	Gao C, Liu B, Zhang R, Tian J, Xin H	Toxicology mechanisms and meth	2026	0
Changes in Circulating Levels of miR-30b During Minipuberty and Puberty in Girls [PMID:40899010]	Albrechtsen HM, Saritas G, Winge SB, Mai	J Clin Endocrinol Metab	2026	0
Epigenetics in chronic rhinosinusitis. [PMID:41442742]	Kumar N, Brar T, Lal D	Curr Opin Otolaryngol Head Nec	2026	0
NEDD8 promotes the ferritinophagy and ferroptosis of neurons in ischemic stroke [PMID:41662890]	Rao W, Huang Y, Li J, Chen Q, Sun J et a	J Stroke Cerebrovasc Dis	2026	0
Inhibition of Ferroptosis in Prostatitis Model by Low Intensity Extracorporeal S [PMID:41714892]	Lin D, Li K, Kuang W, Chen Z, Zhang M	World J Mens Health	2026	0
Deciphering sorafenib resistance in hepatocellular carcinoma via ferroptotic mec [PMID:41763496]	Che L, Zhu L, Zhou L, Zhou Y	Biochim Biophys Acta Rev Cance	2026	0
ACSL4-mediated astrocyte ferroptosis augments neuroinflammation and exacerbates [PMID:41776085]	Wen H, Zi Y, Liu Z, Bai Y, Lin J et al.	Cell Death Differ	2026	0
Extracellular vesicles in type 2 diabetes exhibit elevated miR-155 cargo and Ann [PMID:41786286]	Jackson G, Islam H, de Souza Teixeira AA	Life Sci	2026	0
B4GALT1 deficiency attenuates steatohepatitis by regulating the PPARγ/ACSL4 axis [PMID:41860570]	Chien Y, Xia R, Zhou D, Ai Y, Wu L et al	Hepatol Commun	2026	0
Decoding microRNA-Protein Interaction Networks in Alzheimer's Disease: Molecular [PMID:41918207]	Mishra R, Gupta JK	Curr Alzheimer Res	2026	0
Di-2-ethylhexylphthalate-induced miR155-5P promotes placental ferroptosis. [PMID:41937013]	Gu X, Sun F, Li Y, Yang S, Li Y	Int J Biol Macromol	2026	0
Extracellular Vesicles in Obesity: From Pathophysiological Mediators to Therapeu [PMID:41977323]	Pavlović N, Todorović P, Maglica M, Kopi	Int J Mol Sci	2026	0
Unraveling the impact of risk factors on the ferroptosis-Alzheimer's disease lin [PMID:41498558]	Singh P, Rath SL	Journal of Alzheimer's disease	2026	0
Resveratrol Alleviates Intervertebral Disc Degeneration by Targeting NCOA4-Media [PMID:41873334]	Song C, Wu X, Chen C, Shen B, He Y, Liu	Drug design, development and t	2026	0
Pan-PPAR agonist bezafibrate alleviates psoriasis by suppressing LCN2-dependent [PMID:41662914]	["Xin R", "Zhang J", "Zhang Y", "Dai M",	Free radical biology & medicin	2026	0
Acteoside alleviates sepsis-induced acute lung injury by activating the Nrf2 pat [PMID:41895086]	Wang Y, Zhang W, Zhang M, Zhu Y, Wang W,	Tissue & cell	2026	0
Decoding microRNA-Protein Interaction Networks in Alzheimer's Disease: Molecular [PMID:41918207]	Mishra R, Gupta JK	Current Alzheimer research	2026	0
Ferroptosis and microglial polarization in retinal vein occlusion: pathological [PMID:41924362]	Xu J, Sun M, Wang C, Ju P, Guan XD, Xie	International journal of ophth	2026	0

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning FER in their description or question text

FER

Understanding Entity Pages

Summary

Wiki Pages (6)

FER Gene

Fermitin-2 (FERMT2 / Kindlin-2)

FERMT2 Gene

FERMT2 Protein

FERMT2 Protein

FERMT2 — Fermitin Family Member 2

Pathway Diagram

Outgoing (110)

Incoming (99)

Targeting Hypotheses (30)

Mentioning Analyses (0)

Experiments (5)

Related Papers (20)

Debates (0)

Related Research

Targeting the Mechanistic Link Between AQP4 Dysfunction and Ferroptosis Prevents

ACSL4-Ferroptotic Priming in Stressed Oligodendrocytes Drives White Matter Degen

40 Hz Gamma Entrainment Gates ACSL4-Mediated Ferroptotic Priming to Selectively

pH-Sensitive Bispecific Antibody Targeting Transferrin Receptor for CNS Delivery

LPCAT3-Mediated Lands Cycle Remodeling as the Primary Ferroptotic Priming Engine

ACSL4-Driven Ferroptotic Priming in Disease-Associated Oligodendrocytes Underlie

ALOX15-Driven Enzymatic Ferroptosis in AD Oligodendrocytes via PUFA-PE Peroxidat

LPCAT3-Mediated Lands Cycle Amplification of Ferroptotic Substrate Pools in Dise

LPCAT3-Mediated Lands Cycle Amplification of Ferroptotic Vulnerability in Diseas

Iron-driven lipid peroxidation and GPX4 failure create a ferroptotic amplificati

Seed-Proximal Asymmetric Duplex Stability Confers lncRNA-0021/miR-6361 Binding S

Differential Complement Regulator Expression on Synaptic Membranes (CD55/CD46)

Magnetosonic-Triggered Transferrin Receptor Clustering

Ferroptosis Inhibition for α-Synuclein Neuroprotection

Microglial Efferocytosis Enhancement via GPR32 Superagonists