gene

JAK2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about JAK2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1039Connections

0Hypotheses

2Analyses

50Outgoing

50Incoming

0Experiments

3Debates

Summary

JAK2 is a gene implicated in neurodegeneration research. Key relationships include: activates, therapeutic target, inhibits. Associated with ALS, Aging, Als. Connected to 467 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	JAK2
Aliases	Page for JAK2 Gene
Chromosome	9p24.1
Protein Type	Receptor
Function	is a critical non-receptor tyrosine kinase that mediates cytokine receptor signaling and plays essential roles in immune regulation, hematopoiesis, and cellular stress responses.
Primary Expression	neurons, astrocytes, microglia, and oligodendrocytes, where it participates in neuroinflammation, synaptic
Molecular Weight	130 kDa
Amino Acids	1132 aa
Pathways	JAK-STAT, JAK-STAT pathway
GeneCards	JAK2
Human Protein Atlas	JAK2
Associated Diseases	aging, Als, Alzheimer, APOPTOSIS, Autoimmune
Known Drugs/Compounds	AG490, BARICITINIB, curcumin, Curcumin, CURCUMIN, dasatinib
Interactions	ABCG2, ABL1, ABL2, AGING, Akt, AKT
KG Connections	1039 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

JAK2 Gene - Janus Kinase 2

gene · 1749 words

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JAK2 Protein

protein · 556 words

→

Pathway Diagram

graph TD
    JAK2["JAK2
Janus Kinase 2"] -->|"activates"| STAT["STAT Signaling"]
    JAK2 -->|"activates"| Inflammation["Inflammation"]
    JAK2 -->|"activates"| Immune["Immune Response"]
    JAK2 -->|"activates"| CSF1R["CSF1R"]
    JAK2 -->|"regulates"| GFAP["GFAP"]
    JAK2 -->|"regulates"| GPX4["GPX4"]

    JAK2 -->|"inhibits"| AKT["AKT Pathway"]
    JAK2 -->|"inhibits"| Apoptosis["Apoptosis"]
    JAK2 -->|"inhibits"| Endocytosis["Endocytosis"]

    ABL1["ABL1"] -->|"activates"| JAK2
    ABL2["ABL2"] -->|"activates"| JAK2
    IL7R["IL7R"] -->|"contributes to"| JAK2
    EPOR["EPOR"] -.->|"contributes to"| JAK2

    JAK2 -->|"inhibits"| Alzheimer["Alzheimer's Disease"]
    JAK2 -->|"therapeutic target"| Cancer["Cancer"]
    JAK2 -->|"activates"| Fibrosis["Fibrosis"]
    JAK2 -->|"activates"| ALS["ALS"]

    style JAK2 fill:#e74c3c,stroke:#c0392b,color:#e0e0e0
    style STAT fill:#3498db,stroke:#2980b9,color:#e0e0e0
    style Inflammation fill:#f39c12,stroke:#e67e22,color:#e0e0e0
    style Alzheimer fill:#9b59b6,stroke:#8e44ad,color:#e0e0e0
    style Cancer fill:#9b59b6,stroke:#8e44ad,color:#e0e0e0

Outgoing (667)

Target	Relation	Type	Str
Inflammation	inhibits	disease	1.00
Als	activates	disease	1.00
INFLAMMATION	activates	gene	1.00
Cancer	activates	disease	1.00
Inflammation	activates	disease	1.00
CANCER	activates	gene	1.00
Tumor	activates	disease	0.95
JAK2/STAT5	part_of	pathway	0.95
Tumor	therapeutic_target	disease	0.95
STAT3	phosphorylates	protein	0.90
STAT3	activates	protein	0.90
Apoptosis	inhibits	pathway	0.90
ASTROCYTES	activates	gene	0.90
MICROGLIA	activates	gene	0.90
BCL-2	upregulates	protein	0.88
Aging	activates	disease	0.85
Cancer	therapeutic_target	disease	0.85
Als	inhibits	disease	0.85
IL-6	upstream_of	protein	0.82
TNF-α	activates	protein	0.80
JAK-STAT signaling	participates_in	pathway	0.80
apoptosis pathway	participates_in	pathway	0.80
neuroinflammation	regulates	pathway	0.80
osteoarthritis	causes	disease	0.80
neuroinflammation	inhibits	disease	0.80
STAT3	treats	gene	0.80
AKT	therapeutic_target	gene	0.80
Apoptosis	activates	pathway	0.80
Invasion	activates	pathway	0.80
INFLAMMATION	inhibits	gene	0.80
CANCER	therapeutic_target	gene	0.80
Inflammation	causes	disease	0.75
Carcinoma	activates	disease	0.75
Ischemia	activates	disease	0.75
Breast Cancer	therapeutic_target	disease	0.75
Carcinoma	therapeutic_target	disease	0.75
Als	therapeutic_target	disease	0.75
Neuroinflammation	activates	disease	0.75
Cancer	regulates	disease	0.75
Ischemia	inhibits	disease	0.75
Stroke	inhibits	disease	0.75
Tumor	inhibits	disease	0.75
Ischemia	regulates	disease	0.75
Carcinoma	associated_with	disease	0.75
Cancer	inhibits	disease	0.75
Neuroinflammation	inhibits	disease	0.75
Neurodegeneration	activates	disease	0.75
Als	associated_with	disease	0.75
GFAP	regulates	protein	0.72
Apoptosis	therapeutic_target	pathway	0.70

Incoming (372)

Source	Relation	Type	Str
STAT3	activates	gene	1.00
LRWE	downregulates	compound	0.95
Jolkinolide B	binds_to	drug	0.92
ruxolitinib	inhibits	drug	0.90
Curcumin	inhibits	drug	0.90
CYTOKINES	activates	gene	0.90
AG490	inhibits	drug	0.85
IL-3	activates	gene	0.85
CD1D	phosphorylates	protein	0.85
PI3K	therapeutic_target	gene	0.80
STAT3	therapeutic_target	gene	0.80
STAT3	regulates	gene	0.80
APOPTOSIS	inhibits	gene	0.74
IL-6	activates	gene	0.70
EGFR	targets	gene	0.70
CYTOKINES	inhibits	gene	0.70
NEURODEGENERATION	activates	gene	0.70
HIF	activates	gene	0.70
FERROPTOSIS	activates	gene	0.70
BAX	inhibits	gene	0.70
APOPTOSIS	therapeutic_target	gene	0.70
TNF	inhibits	gene	0.70
EGFR	treats	gene	0.70
IL-6	inhibits	gene	0.70
OXIDATIVE STRESS	inhibits	gene	0.70
TNF	activates	gene	0.70
GENES	activates	gene	0.70
DLAT	activates	gene	0.70
APOPTOSIS	activates	gene	0.70
STAT3	inhibits	gene	0.66
ERK	synergizes_with	gene	0.65
CX3CR1	associated_with	gene	0.65
ROS	regulates	phenotype	0.65
ROS	phosphorylates	phenotype	0.65
AUTOPHAGY	targets	phenotype	0.65
CURCUMIN	activates	drug	0.65
HEPATOCYTES	phosphorylates	cell_type	0.65
HEPATOCYTES	causes	cell_type	0.65
CURCUMIN	regulates	drug	0.65
MICROGLIA	promotes	cell_type	0.65
MICROGLIA	inhibits	cell_type	0.65
ALZHEIMER	associated_with	gene	0.65
AMYLOID	associated_with	gene	0.65
ASTROGLIOSIS	activates	phenotype	0.65
ASTROGLIOSIS	inhibits	phenotype	0.65
MICROGLIA	causes	cell_type	0.65
TREM2	inhibits	gene	0.65
TNF	mediates	gene	0.65
NLRP3	protects_against	gene	0.65
BARICITINIB	treats	drug	0.65

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (2)

Scientific analyses that reference this entity

4R-tau strain-specific spreading patterns in PSP vs CBD

neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.732

What are the mechanisms by which gut microbiome dysbiosis influences Parkinson's

neurodegeneration | 2026-04-01 | 13 hypotheses Top: 0.888

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (3)

Multi-agent debates referencing this entity

Related Research

Hypotheses and analyses mentioning JAK2 in their description or question text

No additional research found