pathway

NOTCH

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NOTCH: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1670Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

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🔀 Pathway Info

Name	NOTCH
Key Genes/Proteins	ACHE, Actin, AD, ADAM10, AGING, AIF1
Related Diseases	Aging, Als, ALS, Alzheimer
Related Pathways	Adaptive Immunity, Akt

Wiki Pages (8)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    NOTCH["NOTCH"] -->|"participates in"| CANCER["CANCER"]
    NOTCH["NOTCH"] -->|"regulates"| CANCER_1["CANCER"]
    NOTCH["NOTCH"] -->|"participates in"| CERVICAL_CANCER["CERVICAL CANCER"]
    NOTCH["NOTCH"] -->|"therapeutic target"| Tumor["Tumor"]
    NOTCH["NOTCH"] -->|"therapeutic target"| Cancer["Cancer"]
    NOTCH["NOTCH"] -->|"therapeutic target"| Cardiovascular["Cardiovascular"]
    ENDOTHELIAL["ENDOTHELIAL"] -.->|"inhibits"| NOTCH["NOTCH"]
    MACROPHAGE["MACROPHAGE"] -.->|"inhibits"| NOTCH["NOTCH"]
    LRP1["LRP1"] -->|"regulates"| NOTCH["NOTCH"]
    DNA_DAMAGE["DNA DAMAGE"] -->|"regulates"| NOTCH["NOTCH"]
    style NOTCH fill:#1b5e20,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (499)

Target	Relation	Type	Str
Progenitor Cell Fate Determination	regulates	process	0.95
Neuronal Subtype Differentiation	involved_in	process	0.90
CANCER	participates_in	disease	0.80
CANCER	regulates	disease	0.80
CERVICAL CANCER	participates_in	disease	0.80
Notch signaling	participates_in	pathway	0.80
SIRT1	activates	gene	0.70
PSEN1	interacts_with	gene	0.70
VEGF	expresses	gene	0.70
PSEN2	interacts_with	gene	0.70
VEGF	mediates	gene	0.70
STING	expresses	gene	0.70
PSEN1	expresses	gene	0.70
PSEN1	degrades	gene	0.70
WNT	mediates	gene	0.70
apoptosis pathway	participates_in	pathway	0.70
Aging	activates	disease	0.65
Cancer	activates	disease	0.65
Fibrosis	contributes_to	disease	0.65
Cancer	inhibits	disease	0.65
Als	therapeutic_target	disease	0.65
Tumor	activates	disease	0.65
Neuroinflammation	therapeutic_target	disease	0.65
Cancer	therapeutic_target	disease	0.65
Dementia	regulates	disease	0.65
Inflammation	expressed_in	disease	0.65
Tumor	therapeutic_target	disease	0.65
Infection	therapeutic_target	disease	0.65
Inflammation	therapeutic_target	disease	0.65
Inflammation	regulates	disease	0.65
ALS	regulates	disease	0.65
Tumor	inhibits	disease	0.65
ALS	interacts_with	disease	0.65
Inflammation	interacts_with	disease	0.65
Tumor	associated_with	disease	0.65
Cardiovascular	therapeutic_target	disease	0.65
PARKINSON	associated_with	disease	0.65
Cancer	associated_with	disease	0.65
Neuroinflammation	expressed_in	disease	0.65
STAT3	phosphorylates	gene	0.65
PARKINSON'S DISEASE	associated_with	disease	0.65
Tumor	expressed_in	disease	0.65
PARKIN	associated_with	gene	0.65
Neurodegeneration	associated_with	disease	0.65
Alzheimer	activates	disease	0.65
Neurodegeneration	transports	disease	0.65
Neurodegeneration	regulates	disease	0.65
ALS	associated_with	disease	0.65
Neuroinflammation	regulates	disease	0.65
Als	degrades	disease	0.65

Incoming (1171)

Source	Relation	Type	Str
Tumor	therapeutic_target	disease	1.00
Cancer	therapeutic_target	disease	1.00
CANCER	therapeutic_target	gene	1.00
Als	therapeutic_target	disease	1.00
Inflammation	therapeutic_target	disease	1.00
Als	regulates	disease	1.00
Inflammation	activates	disease	1.00
SYNCRIP	regulates	gene	0.90
CANCER	regulates	gene	0.90
GENES	associated_with	gene	0.90
NOTCH1	inhibits	gene	0.90
INFLAMMATION	activates	gene	0.90
CANCER	associated_with	gene	0.90
GENES	therapeutic_target	gene	0.90
Als	activates	disease	0.90
GENES	regulates	gene	0.90
Inflammation	regulates	disease	0.90
Cancer	regulates	disease	0.90
INFLAMMATION	therapeutic_target	gene	0.90
ALZHEIMER'S DISEASE	associated_with	disease	0.88
APOPTOSIS	regulates	gene	0.80
Als	expressed_in	disease	0.80
MIRNAS	regulates	gene	0.80
Als	associated_with	disease	0.80
PI3K	regulates	gene	0.80
NF-ΚB	associated_with	gene	0.80
ROS	activates	gene	0.80
PI3K	associated_with	gene	0.80
NOTCH1	expressed_in	gene	0.80
Cancer	associated_with	disease	0.80
Leukemia	therapeutic_target	disease	0.80
Tumor	inhibits	disease	0.80
AKT	associated_with	gene	0.80
ALZHEIMER'S DISEASE	regulates	gene	0.80
Aging	activates	disease	0.80
NEURONS	expresses	cell_type	0.70
GFAP	expressed_in	gene	0.70
APP	expresses	gene	0.70
AMPK	regulates	gene	0.70
NEURONS	activates	cell_type	0.70
ENDOTHELIAL	targets	cell_type	0.70
BACE1	inhibits	gene	0.70
ADAM10	degrades	gene	0.70
HTR2A	transports	gene	0.70
GRIA1	transports	gene	0.70
ENDOTHELIAL	expresses	cell_type	0.70
ENDOTHELIAL	disrupts	cell_type	0.70
GABRA1	transports	gene	0.70
DRD2	transports	gene	0.70
DRD1	transports	gene	0.70

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning NOTCH in their description or question text

No additional research found

NOTCH

Understanding Entity Pages

Wiki Pages (8)

Notch Signaling Pathway in Neurodegeneration

NOTCH2 — Notch Receptor 2

NOTCH2NLC Gene

NOTCH3 Protein

NOTCH3 — Notch Receptor 3