gene

NOTCH1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NOTCH1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

505Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

NOTCH1 is a gene implicated in neurodegeneration research. Key relationships include: activates, associated with, expressed in. Associated with ALS, Aging, Als. Connected to 299 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	NOTCH1
Chromosome	9q34.3
Protein Type	Receptor
Function	The first cleavage is mediated by ADAM10/TACE (alpha-secretase), and the second by gamma-secretase, releasing the Notch intracellular domain (NICD).
Primary Expression	Cerebral cortex, Hippocampus, Neural stem cells, Vascular endothelium
Molecular Weight	272 kDa
Pathways	NOTCH, Notch, Notch signaling, Notch Signaling
UniProt ID	P46531
NCBI Gene ID	4851
Ensembl ID	ENSG00000148400
OMIM	190198
GeneCards	NOTCH1
Human Protein Atlas	NOTCH1
Neurogenesis	Maintains neural stem cell pools and regulates differentiation into neurons or glia
Synaptic plasticity	Modulates long-term potentiation (LTP) and memory formation
Associated Diseases	Als, Alzheimer, Alzheimer's Disease, Autoimmune, Cancer
Interactions	AKT, AKT1, ALDH1L1, ALZHEIMER, ALZHEIMER'S DISEASE, AMPK
KG Connections	502 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: NOTCH1 — AlphaFold P46531 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

NOTCH1 Gene

gene · 690 words

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Pathway Diagram

graph TD
    NOTCH1["NOTCH1"]
    NOTCH1 -->|"causes"| ESCC["ESCC"]
    NOTCH1 -->|"regulates"| thymocyte_specification["thymocyte specification"]
    NOTCH1 -->|"regulates"| thymocyte_development["thymocyte development"]
    NOTCH1 -->|"interacts"| DELTEX1["DELTEX1"]
    NOTCH1 -->|"upregulates"| TREM2["TREM2"]
    NOTCH1 -->|"upregulates"| MHC_I["MHC-I"]
    NOTCH1 -->|"activates"| Neurodegeneration["Neurodegeneration"]
    NOTCH1 -->|"activates"| Alzheimer["Alzheimer"]
    NOTCH1 -->|"activates"| Ms["Ms"]
    NOTCH1 -->|"activates"| Als["Als"]
    DLL4["DLL4"] -->|"activates"| NOTCH1
    KIF2A["KIF2A"] -->|"interacts"| NOTCH1
    CNTN6["CNTN6"] -->|"interacts"| NOTCH1
    PIEZO1["PIEZO1"] -->|"regulates"| NOTCH1
    HNRNPA2B1["HNRNPA2B1"] -->|"activates"| NOTCH1
    CSNK2A1["CSNK2A1"] -->|"regulates"| NOTCH1
    SOX2["SOX2"] -->|"inhibits"| NOTCH1
    EGF["EGF"] -->|"expressed in"| NOTCH1
    GFAP["GFAP"] -->|"inhibits"| NOTCH1
    NESTIN["NESTIN"] -->|"expressed in"| NOTCH1

Outgoing (317)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:NOTCH1	data_in	dataset_row	0.00
ESCC	causes	disease	0.90
Notch	inhibits	pathway	0.90
Lymphatic Sprouting	involved_in	process	0.85
Als	activates	disease	0.85
Als	expressed_in	disease	0.85
Inflammation	activates	disease	0.85
DNA Damage	regulates	process	0.85
Notch signaling	participates_in	pathway	0.80
Alzheimer's Disease	associated_with	disease	0.80
thymocyte specification	regulates	phenotype	0.80
EGFR signalling	upstream_of	pathway	0.80
thymocyte development	regulates	phenotype	0.80
MHC-I	upregulates	protein	0.80
TREM2	upregulates	gene	0.80
DELTEX1	interacts_with	gene	0.80
Notch	expressed_in	pathway	0.80
Ischemia	activates	disease	0.75
Als	therapeutic_target	disease	0.75
Als	inhibits	disease	0.75
Neuroinflammation	activates	disease	0.75
Tumor	activates	disease	0.75
Als	associated_with	disease	0.75
Tumor	therapeutic_target	disease	0.75
Neurodegeneration	activates	disease	0.75
Cancer	associated_with	disease	0.75
Cancer	activates	disease	0.75
Angiogenesis	activates	pathway	0.70
Notch	therapeutic_target	pathway	0.70
oxidative stress response	participates_in	pathway	0.70
Differentiation	inhibits	pathway	0.70
Notch	activates	pathway	0.70
NEUROINFLAMMATION	activates	gene	0.70
Angiogenesis	regulates	pathway	0.70
Neural Progenitor Cells	expressed_in	cell_type	0.70
IL-6	activates	gene	0.70
T cells	expressed_in	cell_type	0.70
APOPTOSIS	treats	phenotype	0.65
Parkinson	activates	disease	0.65
Aging	activates	disease	0.65
Depression	activates	disease	0.65
T CELLS	regulates	cell_type	0.65
OXIDATIVE STRESS	regulates	phenotype	0.65
STING	treats	gene	0.65
ISCHEMIA	regulates	disease	0.65
T CELLS	activates	cell_type	0.65
Cancer	inhibits	disease	0.65
Tumor	inhibits	disease	0.65
Carcinoma	inhibits	disease	0.65
Carcinoma	associated_with	disease	0.65

Incoming (188)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:NOTCH1	data_in	dataset_row	0.00
ORAI1	regulates	protein	0.90
DLL4	activates	protein	0.90
PSEN1	cleaves	gene	0.85
KIF2A	interacts_with	gene	0.80
CNTN6	interacts_with	gene	0.80
PI3K	therapeutic_target	gene	0.70
BDNF	activates	gene	0.70
CYTOKINES	associated_with	phenotype	0.65
TH	activates	gene	0.65
INFLAMMATION	inhibits	phenotype	0.65
PSEN1	causes	gene	0.65
ISCHEMIA	inhibits	disease	0.65
TNF	inhibits	gene	0.65
VEGFA	regulates	gene	0.65
MELATONIN	protects_against	drug	0.65
MELATONIN	regulates	drug	0.65
ASTROCYTES	inhibits	gene	0.60
ASTROCYTE	activates	gene	0.60
AND	activates	gene	0.60
DTX1	activates	gene	0.60
DTX3L	activates	gene	0.60
KLF2	activates	gene	0.60
DNA	regulates	gene	0.60
ALZHEIMER'S DISEASE	activates	gene	0.60
ALZHEIMER	activates	gene	0.60
TAU	activates	gene	0.60
CANCER	activates	gene	0.60
MTORC1	expressed_in	gene	0.60
CANCER	regulates	gene	0.60
UBIQUITIN	regulates	gene	0.60
JAG1	interacts_with	gene	0.60
OXIDATIVE STRESS	expressed_in	gene	0.60
RELB	expressed_in	gene	0.60
IGF1	interacts_with	gene	0.60
APOE	expressed_in	gene	0.60
RPS6KB1	interacts_with	gene	0.60
INFLAMMATION	expressed_in	gene	0.60
C-JUN	associated_with	gene	0.60
DTX1	regulates	gene	0.60
GENES	regulates	gene	0.60
KLF2	regulates	gene	0.60
DTX3L	regulates	gene	0.60
PIEZO	regulates	gene	0.60
NOTCH	regulates	gene	0.60
AMPK	inhibits	gene	0.60
DEPRESSION	activates	gene	0.60
MICROGLIA	activates	gene	0.60
PIEZO1	regulates	gene	0.60
DLK2	inhibits	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning NOTCH1 in their description or question text

No additional research found