concept

HIF1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HIF1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

546Connections

5Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

HIF1 is a concept in neurodegeneration research. Key relationships include: interacts with, regulates, activates. Associated with AD, ALI, ALS. Connected to 279 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	HIF1
Key Genes/Proteins	ABCD3, AGING, Akt, ALZHEIMER, ALZHEIMER DISEASE, ALZHEIMER'S DISEASE
Related Diseases	AD, Aging, ALI, Als, ALS
Linked Hypotheses	6 hypotheses

Wiki Pages (2)

Knowledge base pages for this entity

HIF1AN — Hypoxia Inducible Factor 1 Subunit Alpha Inhibitor

gene · 2096 words

→

HIF1A Gene - Hypoxia Inducible Factor 1 Subunit Alpha

gene · 708 words

→

Pathway Diagram

graph TD
    HIF1["HIF1"]
    HIF1 -->|"activates"| BNIP3["BNIP3"]
    HIF1 -->|"interacts"| Dementia["Dementia"]
    HIF1 -->|"interacts"| Alzheimer["Alzheimer"]
    HIF1 -->|"interacts"| Als["Als"]
    HIF1 -->|"interacts"| Cardiovascular["Cardiovascular"]
    HIF1 -->|"interacts"| Parkinson["Parkinson"]
    HIF1 -->|"interacts"| Ms["Ms"]
    HIF1 -->|"activates"| Carcinoma["Carcinoma"]
    HIF1 -->|"activates"| Cancer["Cancer"]
    HIF1 -->|"activates"| Cardiac["Cardiac"]
    CMVS["CMVS"] -->|"activates"| HIF1
    MFN1["MFN1"] -->|"interacts"| HIF1
    DNM1L["DNM1L"] -->|"interacts"| HIF1
    DDIT3["DDIT3"] -->|"interacts"| HIF1
    ABCD3["ABCD3"] -->|"interacts"| HIF1
    LMNA["LMNA"] -->|"interacts"| HIF1
    MAP1LC3B["MAP1LC3B"] -->|"interacts"| HIF1
    OPTN["OPTN"] -->|"interacts"| HIF1
    AMBRA1["AMBRA1"] -->|"interacts"| HIF1
    CTSD["CTSD"] -->|"interacts"| HIF1

Outgoing (317)

Target	Relation	Type	Str
BNIP3	activates	protein	0.80
Cancer	regulates	disease	0.75
NIX	regulates	protein	0.74
oxidative stress response	participates_in	pathway	0.70
autophagy pathway	participates_in	pathway	0.70
CANCER	regulates	gene	0.70
Mtor	activates	pathway	0.70
MTOR	activates	gene	0.70
angiogenesis	regulates	pathway	0.70
radioresistance	regulates	pathway	0.70
chemoresistance	regulates	pathway	0.70
proliferation	regulates	pathway	0.70
metastasis	regulates	pathway	0.70
ALS	regulates	disease	0.65
Cardiovascular	activates	disease	0.65
Tumor	causes	disease	0.65
Parkinson	interacts_with	disease	0.65
Cardiovascular	interacts_with	disease	0.65
Frontotemporal Dementia	interacts_with	disease	0.65
Neuroinflammation	regulates	disease	0.65
Als	interacts_with	disease	0.65
Cardiovascular	causes	disease	0.65
Tumor	activates	disease	0.65
Carcinoma	activates	disease	0.65
Cancer	activates	disease	0.65
Ms	interacts_with	disease	0.65
Cardiac	activates	disease	0.65
Ms	activates	disease	0.65
Cardiovascular	therapeutic_target	disease	0.65
Cancer	causes	disease	0.65
Inflammation	regulates	disease	0.65
Alzheimer	interacts_with	disease	0.65
Dementia	interacts_with	disease	0.65
Ftd	interacts_with	disease	0.65
Carcinoma	causes	disease	0.65
Amyotrophic Lateral Sclerosis	interacts_with	disease	0.65
Ulcerative Colitis	activates	disease	0.65
Tumor	associated_with	disease	0.65
Neuropathy	therapeutic_target	disease	0.65
Als	regulates	disease	0.65
Ms	inhibits	disease	0.65
Traumatic Brain Injury	regulates	disease	0.65
Ischemia	activates	disease	0.65
Als	activates	disease	0.65
Dementia	therapeutic_target	disease	0.65
Carcinoma	associated_with	disease	0.65
Senescence	therapeutic_target	disease	0.65
Neurodegeneration	activates	disease	0.65
Glioblastoma	activates	disease	0.65
Alzheimer	activates	disease	0.65

Incoming (229)

Source	Relation	Type	Str
Ros	activates	compound	0.80
MTOR	promotes	protein	0.80
CMVS	activates	protein	0.64
FOXO3	regulates	gene	0.60
NRF2	regulates	gene	0.60
MITOPHAGY	regulates	gene	0.60
P62	regulates	gene	0.60
ERK	activates	gene	0.60
DUSP9	activates	gene	0.60
FOXO3	activates	gene	0.60
MTOR	causes	gene	0.60
MITOCHONDRIAL DYSFUNCTION	regulates	gene	0.60
ROS	regulates	gene	0.60
LC3	regulates	gene	0.60
OXIDATIVE STRESS	regulates	gene	0.60
NIX	regulates	gene	0.60
DEMENTIA	interacts_with	gene	0.60
MAPK8	interacts_with	gene	0.60
PINK1	interacts_with	gene	0.60
PRESENILIN	interacts_with	gene	0.60
ALZHEIMER DISEASE	interacts_with	gene	0.60
CAT	interacts_with	gene	0.60
BECN1	interacts_with	gene	0.60
ALZHEIMER	interacts_with	gene	0.60
UBIQUITIN	interacts_with	gene	0.60
ROS	interacts_with	gene	0.60
SNCA	interacts_with	gene	0.60
LC3	interacts_with	gene	0.60
EMD	interacts_with	gene	0.60
MIRO1	interacts_with	gene	0.60
PTEN	interacts_with	gene	0.60
SESN2	interacts_with	gene	0.60
FUNDC1	interacts_with	gene	0.60
NUCLEOPHAGY	interacts_with	gene	0.60
PARKINSON	interacts_with	gene	0.60
JNK	interacts_with	gene	0.60
RTN3	interacts_with	gene	0.60
RIP3	interacts_with	gene	0.60
EIF2AK3	interacts_with	gene	0.60
LC3B	interacts_with	gene	0.60
DRP1	interacts_with	gene	0.60
CANX	interacts_with	gene	0.60
HIF	interacts_with	gene	0.60
RB1	interacts_with	gene	0.60
PGAM5	interacts_with	gene	0.60
HIF	activates	gene	0.60
TIGAR	regulates	gene	0.60
NRF2	activates	gene	0.60
GBM	activates	gene	0.60
RNA	activates	gene	0.60

Targeting Hypotheses (5)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Microglial Metabolic Trained Immunity via mTOR-HIF1α Axis	0.644	developmental neurobiology	Do perinatal immune challenges create pe
Metabolic Rewiring via SPP1-Induced HIF1α Glycolytic Shift	0.620	neuroinflammation	What molecular mechanisms mediate SPP1-i
HIF1A stabilization lowers the activation threshold of circa	0.566	neuroinflammation	Do microglia actually switch between gly
Dysregulated microglial glycolysis via HIF1α activation shif	0.520	neurodegeneration	Synaptic pruning by microglia in neurode
CCR2-Mediated Microglial Replacement Drives mTOR-HIF1α Metab	0.000	developmental neurobiology	Do perinatal immune challenges create pe

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning HIF1 in their description or question text

No additional research found