concept

HV1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HV1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

56Connections

0Hypotheses

0Analyses

44Outgoing

12Incoming

0Experiments

0Debates

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💡 Concept Info

Name	HV1
Key Genes/Proteins	AKT, AND, Cytokine, GENES, HIF1, HIF1A
Related Diseases	cognitive impairment, Cognitive Impairments, Inflammation
Related Pathways	Akt, Glycolysis

Pathway Diagram

graph TD
    HV1["HV1"]
    HV1 -.protects against.-> Lipopolysaccharide_Induced_Neu["Lipopolysaccharide-Induced Neuroinflammation"]
    HV1 -.protects against.-> Neuroinflammation["Neuroinflammation"]
    HV1 -->|"modulates"| NF__B_Signaling_Pathway["NF-kappaB Signaling Pathway"]
    HV1 -->|"involved_in"| Microglial_Activation["Microglial Activation"]
    HV1 -->|"regulates"| HIF1_["HIF1alpha"]
    HV1 -->|"risk_factor_for"| Cognitive_Impairments["Cognitive Impairments"]
    GENES["GENES"] -->|"inhibits"| HV1
    PFKFB3["PFKFB3"] -->|"inhibits"| HV1
    PI3K["PI3K"] -->|"regulates"| HV1
    MICROGLIA["MICROGLIA"] -->|"regulates"| HV1
    NEUROINFLAMMATION["NEUROINFLAMMATION"] -->|"regulates"| HV1
    AKT["AKT"] -->|"regulates"| HV1
    INFLAMMATION["INFLAMMATION"] -->|"regulates"| HV1
    NF__B["NF-KappaB"] -->|"regulates"| HV1

Outgoing (44)

Target	Relation	Type	Str
Lipopolysaccharide-Induced Neuroinflammation	protects_against	process	0.95
NF-κB	activates	pathway	0.95
Neuroinflammation	protects_against	process	0.95
Microglial Activation	involved_in	process	0.90
NF-κB Signaling Pathway	regulates	pathway	0.90
NF-κB Signaling Pathway	modulates	pathway	0.90
HIF1α	regulates	protein	0.85
Microglial Activation	contributes_to	process	0.85
Cognitive Impairments	risk_factor_for	disease	0.85
Microglial Activation	regulates	process	0.85
microglial activation	promotes	process	0.85
HIF1A	upregulates	gene	0.85
cognitive impairment	therapeutic_target	phenotype	0.80
cognitive impairment	contributes_to	phenotype	0.80
HIF1α	regulates	transcription_factor	0.80
MICROGLIAL	expressed_in	cell_type	0.80
NF-κB	regulates	pathway	0.80
neuroinflammation	promotes	process	0.80
Ms	associated_with	disease	0.65
Neuroinflammation	regulates	disease	0.65
Inflammation	regulates	disease	0.65
NEUROINFLAMMATION	regulates	gene	0.60
Glycolysis	inhibits	pathway	0.60
Akt	regulates	pathway	0.60
Nf-Κb	regulates	pathway	0.60
Pi3K	regulates	pathway	0.60
HK2	inhibits	gene	0.60
NF-ΚB	regulates	gene	0.60
AND	regulates	gene	0.60
AKT	regulates	gene	0.60
INFLAMMATION	regulates	gene	0.60
HIF1A	inhibits	protein	0.60
GENES	inhibits	gene	0.60
RNA	regulates	gene	0.60
PFKFB3	inhibits	gene	0.60
Cytokine	regulates	protein	0.60
HIF1	regulates	gene	0.60
PI3K	regulates	gene	0.60
Neuroinflammatory	contributes_to	pathway	0.60
Pi3K/Akt	regulates	pathway	0.60
MICROGLIA	regulates	gene	0.60
Microglia	regulates	cell_type	0.60
Ras	associated_with	protein	0.60
Microglia	expressed_in	cell_type	0.55

Incoming (12)

Source	Relation	Type	Str
GENES	inhibits	gene	0.60
PFKFB3	inhibits	gene	0.60
PI3K	regulates	gene	0.60
MICROGLIA	regulates	gene	0.60
NEUROINFLAMMATION	regulates	gene	0.60
AKT	regulates	gene	0.60
INFLAMMATION	regulates	gene	0.60
NF-ΚB	regulates	gene	0.60
HK2	inhibits	gene	0.60
RNA	regulates	gene	0.60
AND	regulates	gene	0.60
HIF1	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning HV1 in their description or question text

No additional research found