biological_process

ANGIOGENESIS

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ANGIOGENESIS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1200Connections

1Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

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🧬 Biological Process Info

Name	ANGIOGENESIS
Key Genes/Proteins	AKT, AMYLOID
Related Diseases	ALZHEIMER, ALZHEIMER'S DISEASE, ASTHMA

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Angiogenesis Pathway

mechanism · 1518 words

→

Pathway Diagram

graph TD
    ANGIOGENESIS["ANGIOGENESIS"] -->|"associated"| CANCER["CANCER"]
    style CANCER fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#e0e0e0
    ANGIOGENESIS["ANGIOGENESIS"] -->|"targets"| STING["STING"]
    style STING fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    ANGIOGENESIS["ANGIOGENESIS"] -->|"activates"| TUMOR["TUMOR"]
    style TUMOR fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#e0e0e0
    ANGIOGENESIS["ANGIOGENESIS"] -->|"accumulates in"| CELL_MIGRATION["CELL MIGRATION"]
    style CELL_MIGRATION fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#e0e0e0
    ANGIOGENESIS["ANGIOGENESIS"] -->|"accumulates in"| INFLAMMATION["INFLAMMATION"]
    style INFLAMMATION fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#e0e0e0
    ANGIOGENESIS["ANGIOGENESIS"] -->|"regulates"| APOPTOSIS["APOPTOSIS"]
    style APOPTOSIS fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#e0e0e0
    ANGIOGENESIS["ANGIOGENESIS"] -->|"targets"| OXIDATIVE_STRESS["OXIDATIVE STRESS"]
    style OXIDATIVE_STRESS fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#e0e0e0
    NTN1["NTN1"] -->|"associated"| ANGIOGENESIS["ANGIOGENESIS"]
    style NTN1 fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    BMAL1["BMAL1"] -->|"regulates"| ANGIOGENESIS["ANGIOGENESIS"]
    style BMAL1 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    AKT["AKT"] -->|"co discussed"| ANGIOGENESIS["ANGIOGENESIS"]
    style AKT fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    CYTOKINES["CYTOKINES"] -->|"associated"| ANGIOGENESIS["ANGIOGENESIS"]
    style CYTOKINES fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    STING_1["STING"] -->|"activates"| ANGIOGENESIS["ANGIOGENESIS"]
    style STING_1 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    style ANGIOGENESIS fill:#5d4400,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (220)

Target	Relation	Type	Str
Wound Healing	contributes_to	process	0.95
Bone Fracture Healing	involved_in	process	0.95
Wound Healing	involved_in	process	0.95
Brain Development	involved_in	process	0.95
Fracture Healing	contributes_to	process	0.90
Brain Vascular Malformations	associated_with	disease	0.90
Brain Tumors	associated_with	disease	0.90
ENDOTHELIAL CELLS	regulates	cell_type	0.80
VEGF	interacts_with	entity	0.70
ENDOTHELIAL CELLS	associated_with	cell_type	0.65
EGF	inhibits	gene	0.60
oxidative stress	activates	process	0.60
apoptosis	associated_with	pathway	0.60
AQP1	regulates	gene	0.60
AQP1	activates	gene	0.60
CLOCK	binds_to	gene	0.60
CLOCK	regulates	gene	0.60
NPM1	activates	gene	0.60
SRPK1	phosphorylates	gene	0.60
MMP2	inhibits	gene	0.60
MMP9	inhibits	gene	0.60
CX3CR1	activates	gene	0.60
PIEZO1	activates	gene	0.60
neuroinflammation	binds_to	process	0.60
AKT	activates	gene	0.58
ALZHEIMER'S DISEASE	depleted_in	disease	0.55
Immune Response	interacts_with	pathway	0.55
Epigenetic	interacts_with	pathway	0.55
Apoptosis	interacts_with	pathway	0.55
Blood-Brain Barrier	interacts_with	pathway	0.55
Pi3K	interacts_with	pathway	0.55
Autophagy	interacts_with	pathway	0.55
Mtor	interacts_with	pathway	0.55
Adaptive Immunity	interacts_with	pathway	0.55
Glycolysis	interacts_with	pathway	0.55
Notch	interacts_with	pathway	0.55
TNF	co_discussed	entity	0.50
OLIGODENDROCYTE	co_discussed	entity	0.50
REMYELINATION	co_discussed	entity	0.50
WHITE MATTER	co_discussed	entity	0.50
DEMENTIA	co_discussed	entity	0.50
Astrocyte	associated_with	cell_type	0.50
Stem Cell	associated_with	cell_type	0.50
Neuron	associated_with	cell_type	0.50
BBB	co_discussed	entity	0.50
BLOOD-BRAIN BARRIER	co_discussed	entity	0.50
INSULIN SIGNALING	co_discussed	entity	0.50
TGFB1	co_discussed	entity	0.50
ERK	co_discussed	entity	0.50
DEMYELINATION	co_discussed	entity	0.50

Incoming (980)

Source	Relation	Type	Str
OXIDATIVE STRESS	activates	gene	1.00
CANCER	therapeutic_target	gene	1.00
CANCER	activates	gene	1.00
INFLAMMATION	inhibits	gene	1.00
APOPTOSIS	inhibits	gene	1.00
PI3K	activates	gene	1.00
Inflammation	inhibits	disease	1.00
AKT	therapeutic_target	gene	1.00
AKT	regulates	gene	1.00
GENES	activates	gene	1.00
MTOR	therapeutic_target	gene	1.00
PI3K	regulates	gene	1.00
PI3K	therapeutic_target	gene	1.00
Inflammation	activates	disease	1.00
Cancer	activates	disease	1.00
Tumor	activates	disease	1.00
Tumor	regulates	disease	1.00
Tumor	inhibits	disease	1.00
Als	activates	disease	1.00
APOPTOSIS	activates	gene	1.00
Als	inhibits	disease	1.00
Als	regulates	disease	1.00
Cancer	inhibits	disease	1.00
CANCER	inhibits	gene	1.00
Tumor	therapeutic_target	disease	1.00
AKT	activates	gene	1.00
Cancer	regulates	disease	1.00
Ischemia	activates	disease	1.00
INFLAMMATION	activates	gene	1.00
CANCER	regulates	gene	1.00
GENES	regulates	gene	1.00
APOPTOSIS	regulates	gene	1.00
Cancer	therapeutic_target	disease	1.00
Inflammation	therapeutic_target	disease	1.00
STAT3	activates	gene	1.00
Als	therapeutic_target	disease	1.00
VEGF	activates	gene	1.00
INFLAMMATION	therapeutic_target	gene	1.00
AKT	inhibits	gene	1.00
PI3K	inhibits	gene	1.00
TNF-Α	activates	gene	1.00
TNF	activates	gene	1.00
MTOR	regulates	gene	1.00
AUTOPHAGY	regulates	gene	1.00
Inflammation	regulates	disease	1.00
CYTOKINES	activates	gene	1.00
MICRORNAS	regulates	gene	1.00
CYTOKINES	therapeutic_target	gene	1.00
Pericyte-Derived Extracellular Vesicles	promotes	cell_type	0.95
FGF2	involved_in	protein	0.95

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Moderate hyperoxia (1.5-2.0 ATA) optimally stabilizes HIF-1α	0.470	neurodegeneration	What are the optimal oxygen pressure, du

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning ANGIOGENESIS in their description or question text

No additional research found