gene 708 words KG: HIF1A
Contents

HIF1A Gene - Hypoxia Inducible Factor 1 Subunit Alpha

🧬 Gene Info
Gene SymbolHIF
Full NameHypoxia Inducible Factor 1 Subunit Alpha
Chromosome14q21.1
FunctionPHD inactivation: Reduced prolyl hydroxylation
PathwaysAerobic Glycolysis, Akt, Autophagy, Epigenetic, Immune Response
UniProt IDQ16665
NCBI Gene ID3091
Ensembl IDENSG00000100644
OMIM603348
GeneCardsHIF
Human Protein AtlasHIF
Associated DiseasesAD, ALI, Als, Alzheimer, ATHEROSCLEROSIS
InteractionsABCD3, acetylcholine, ACHE, AD, AGING, AKT
SciDEX HypothesesHIF1A stabilization lowers the activation threshol
Moderate hyperoxia (1.5-2.0 ATA) optimally stabili
KG Connections1184 knowledge graph edges
DatabasesGeneCardsHPASTRING

No AI portrait yet

Knowledge Graph

Related Hypotheses (22)

Mitochondrial SPM Synthesis Platform Engineering
Score: 0.65
CYP46A1 Overexpression Gene Therapy
Score: 0.92
Transcriptional Autophagy-Lysosome Coupling
Score: 0.88
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79

Related Analyses (12)

Neuroinflammation and microglial priming in early Alzheimer'
neurodegeneration · completed
Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived

Related Experiments (1)

Cytochrome Therapeutics
clinical · proposed · Score: 0.40

See Also (12)

AMPK (AMP-Activated Protein Kinase)
entity · KG edge: activates
ABCD3 Gene
gene · KG edge: activates
ADAM10 — A Disintegrin And Metalloproteinase Domain 10
gene · KG edge: therapeutic_target
ADRB2 Gene
gene · KG edge: therapeutic_target
AGGF1 Gene - Angiogenic Factor
gene · KG edge: upregulates

Knowledge Graph (12 edges)

sorafenib regulates HIF1A
HIF1A regulates SLC7A11
FOXO3 regulates HIF1A
STAT1 activates HIF1A
STAT3 activates HIF1A
CAT interacts_with HIF1A
OPTN interacts_with HIF1A
DNM1L interacts_with HIF1A
CANX interacts_with HIF1A
LGALS3 interacts_with HIF1A

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