Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Ulcerative Colitis: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Associated Genes | AMPK, APOPTOSIS, AUTOPHAGY, BAX, BCL-2, CANCER, CAT, DNA |
| Therapeutic Agents | BBR, Berberine, Coptis Chinensis, Coptis Chinensis Franch. Extract, Linderae Radix Water Extract, LRWE |
| KG Connections | 259 knowledge graph edges |
| Databases | OMIMOrphanetClinicalTrialsPubMed |
graph TD
Ulcerative_Colitis["Ulcerative Colitis"]
Inflammatory_Bowel_Disease{"Inflammatory Bowel Disease"}
Ulcerative_Colitis -->|"associated_with"| Inflammatory_Bowel_Disease
Inflammation{"Inflammation"}
Ulcerative_Colitis -.->|"inhibits"| Inflammation
INFLAMMATION(["INFLAMMATION"])
INFLAMMATION -.->|"inhibits"| Ulcerative_Colitis
style Ulcerative_Colitis fill:#1a3a4a,stroke:#ef5350,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Inflammatory Bowel Disease | associated_with | disease | 1.00 |
| Inflammation | inhibits | disease | 0.85 |
| Inflammation | associated_with | disease | 0.85 |
| Inflammatory Bowel Disease | therapeutic_target | disease | 0.75 |
| Inflammation | regulates | disease | 0.75 |
| Inflammation | activates | disease | 0.75 |
| Als | inhibits | disease | 0.75 |
| Inflammation | therapeutic_target | disease | 0.75 |
| TNF-α | associated_with | protein | 0.70 |
| Immune Response | therapeutic_target | pathway | 0.70 |
| Pi3K/Akt | treats | pathway | 0.70 |
| Microbiota | treats | pathway | 0.70 |
| Oxidative Stress | therapeutic_target | pathway | 0.70 |
| Apoptosis | inhibits | pathway | 0.70 |
| Oxidative Stress | associated_with | pathway | 0.70 |
| Inflammatory Bowel Disease | activates | disease | 0.65 |
| Als | activates | disease | 0.65 |
| Inflammation | causes | disease | 0.65 |
| Als | regulates | disease | 0.65 |
| Inflammation | treats | disease | 0.65 |
| Als | therapeutic_target | disease | 0.65 |
| Apoptosis | associated_with | pathway | 0.60 |
| Angiogenesis | therapeutic_target | pathway | 0.60 |
| Ferroptosis | inhibits | pathway | 0.60 |
| Erk Signaling | inhibits | pathway | 0.60 |
| Tgf-Β | inhibits | pathway | 0.60 |
| Ferroptosis | activates | pathway | 0.60 |
| Dysbiosis | therapeutic_target | pathway | 0.60 |
| Ampk Signaling | implicated_in | pathway | 0.60 |
| Nf-Κb | activates | pathway | 0.60 |
| Complement | regulates | pathway | 0.60 |
| Autophagy | regulates | pathway | 0.60 |
| Ferroptosis | treats | pathway | 0.60 |
| Oxidative Stress | treats | pathway | 0.60 |
| Gut Microbiome | treats | pathway | 0.60 |
| Wnt | activates | pathway | 0.60 |
| Immune Response | implicated_in | pathway | 0.60 |
| Pyroptosis | implicated_in | pathway | 0.60 |
| Inflammasome | implicated_in | pathway | 0.60 |
| Necroptosis | implicated_in | pathway | 0.60 |
| Microbiota | associated_with | pathway | 0.60 |
| Jak-Stat | inhibits | pathway | 0.60 |
| Metastasis | therapeutic_target | pathway | 0.60 |
| Autophagy | causes | pathway | 0.60 |
| Immune Response | regulates | pathway | 0.60 |
| Microbiota | therapeutic_target | pathway | 0.60 |
| Notch | treats | pathway | 0.60 |
| Mapk | treats | pathway | 0.60 |
| Immune Response | treats | pathway | 0.60 |
| Autophagy | therapeutic_target | pathway | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| INFLAMMATION | inhibits | gene | 0.95 |
| INFLAMMATION | associated_with | gene | 0.95 |
| Linderae Radix Water Extract | treats | drug | 0.95 |
| licorice | treats | drug | 0.95 |
| LRWE | treats | drug | 0.95 |
| BBR | treats | compound | 0.95 |
| LRWE | treats | compound | 0.95 |
| TNF-Α | promotes | protein | 0.93 |
| Coptis Chinensis | treats | compound | 0.92 |
| IL-6 | associated_with | protein | 0.90 |
| BBR | treats | drug | 0.90 |
| Berberine | treats | compound | 0.90 |
| JAK/STAT Signaling Pathway | involved_in | pathway | 0.90 |
| anti-TNF-α monoclonal antibody | treats | drug | 0.90 |
| berberine | treats | drug | 0.90 |
| TNF-Α | inhibits | gene | 0.85 |
| TNF | inhibits | gene | 0.85 |
| TNF | promotes | protein | 0.85 |
| GENES | activates | gene | 0.85 |
| INFLAMMATION | therapeutic_target | gene | 0.85 |
| INFLAMMATION | activates | gene | 0.85 |
| Hesperetin | treats | drug | 0.85 |
| CYTOKINES | inhibits | gene | 0.85 |
| Coptis Chinensis Franch. Extract | treats | compound | 0.85 |
| INFLAMMATION | regulates | gene | 0.85 |
| IL-1β | biomarker_for | protein | 0.85 |
| IL-6 | biomarker_for | protein | 0.85 |
| Nicotiflorin | treats | drug | 0.80 |
| autophagy | treats | process | 0.80 |
| EFHD2 | protects_against | protein | 0.80 |
| CGAS-STING | involved_in | pathway | 0.80 |
| Nrf2/PINK1 pathway | modulates | pathway | 0.80 |
| EFHD2 | biomarker_for | gene | 0.75 |
| CYTOKINES | regulates | gene | 0.75 |
| OXIDATIVE STRESS | associated_with | gene | 0.75 |
| GENES | inhibits | gene | 0.75 |
| AKT | treats | gene | 0.75 |
| P53 | activates | gene | 0.75 |
| IL-6 | inhibits | gene | 0.75 |
| PI3K | treats | gene | 0.75 |
| INFLAMMATION | causes | gene | 0.75 |
| CANCER | associated_with | gene | 0.75 |
| APOPTOSIS | inhibits | gene | 0.75 |
| INFLAMMATION | treats | gene | 0.75 |
| CANCER | therapeutic_target | gene | 0.75 |
| CD4 | regulates | gene | 0.75 |
| GENES | therapeutic_target | gene | 0.75 |
| OXIDATIVE STRESS | therapeutic_target | gene | 0.75 |
| IL6 | associated_with | protein | 0.70 |
| Cancer | therapeutic_target | disease | 0.65 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning Ulcerative Colitis in their description or question text
No additional research found