phenotype

ROS

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ROS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

4238Connections

30Hypotheses

4Analyses

50Outgoing

50Incoming

11Experiments

5Debates

Summary

ROS is a phenotype associated with neurodegeneration research. Key relationships include: activates, interacts with, regulates. Associated with AD, ALI, ALS. Connected to 1918 entities in the SciDEX knowledge graph.

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Wiki Pages (9)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    subgraph Signaling["Signaling"]
        ROS["ROS"] -->|"activates"| NRF2["NRF2"]
        ROS["ROS"] -->|"activates"| AUTOPHAGY["AUTOPHAGY"]
        ROS["ROS"] -->|"activates"| FERROPTOSIS_1["FERROPTOSIS"]
        ROS["ROS"] -->|"regulates"| PI3K["PI3K"]
        ROS["ROS"] -->|"activates"| ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
        ROS["ROS"] -->|"regulates"| GENES["GENES"]
        ROS["ROS"] -->|"activates"| ALZHEIMER["ALZHEIMER"]
        SLC7A11["SLC7A11"] -.->|"inhibits"| ROS["ROS"]
        AUTOPHAGY_2["AUTOPHAGY"] -->|"activates"| ROS["ROS"]
        OXIDATIVE_STRESS["OXIDATIVE STRESS"] -->|"activates"| ROS["ROS"]
        MITOPHAGY["MITOPHAGY"] -->|"activates"| ROS["ROS"]
        SLC7A11_3["SLC7A11"] -->|"activates"| ROS["ROS"]
        BAX["BAX"] -->|"activates"| ROS["ROS"]
    end
    subgraph Pathology["Pathology"]
        ROS["ROS"] -->|"causes"| DNA["DNA"]
        ROS["ROS"] -->|"causes"| FERROPTOSIS["FERROPTOSIS"]
    end
    style ROS fill:#5d4400,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0,font-weight:bold
    style NRF2 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style AUTOPHAGY fill:#1b5e20,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style DNA fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style FERROPTOSIS fill:#5d4400,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style FERROPTOSIS_1 fill:#5d4400,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style PI3K fill:#006494,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style ALZHEIMER_S_DISEASE fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style GENES fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style ALZHEIMER fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style SLC7A11 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style AUTOPHAGY_2 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style OXIDATIVE_STRESS fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style MITOPHAGY fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style SLC7A11_3 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style BAX fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0

Outgoing (2535)

Target	Relation	Type	Str
Mitophagy	regulates	pathway	1.00
BCL-2	activates	gene	1.00
BECN1	activates	gene	1.00
Cardiovascular	activates	disease	1.00
FERROPTOSIS	activates	phenotype	1.00
Carcinoma	activates	disease	1.00
JUN	activates	gene	1.00
P53	activates	gene	1.00
FERROPTOSIS	regulates	gene	1.00
Oxidative Stress	inhibits	pathway	1.00
JNK	activates	gene	1.00
NLRP3	activates	gene	1.00
INFLAMMATION	regulates	gene	1.00
Ferroptosis	regulates	pathway	1.00
Senescence	activates	disease	1.00
Inflammasome	activates	pathway	1.00
AMPK	activates	gene	1.00
Glycolysis	activates	pathway	1.00
GENES	activates	gene	1.00
Inflammation	regulates	disease	1.00
OXIDATIVE STRESS	inhibits	gene	1.00
Als	associated_with	disease	1.00
SIRT1	activates	gene	1.00
Stroke	activates	disease	1.00
NEUROTOXICITY	activates	gene	1.00
MITOCHONDRIAL DYSFUNCTION	activates	gene	1.00
Autophagy	activates	pathway	1.00
Als	causes	disease	1.00
Apoptosis	inhibits	pathway	1.00
Aging	regulates	disease	1.00
FERROPTOSIS	causes	phenotype	1.00
Cancer	causes	disease	1.00
MTOR	activates	gene	1.00
Oxidative Stress	treats	pathway	1.00
CANCER	causes	gene	1.00
TNF	activates	gene	1.00
Aging	activates	disease	1.00
Tumor	associated_with	disease	1.00
NRF2	activates	gene	1.00
P62	activates	gene	1.00
DNA	causes	gene	1.00
MITOCHONDRIA	inhibits	gene	1.00
LC3	activates	gene	1.00
Alzheimer	activates	disease	1.00
AUTOPHAGY	activates	pathway	1.00
NEUROINFLAMMATION	activates	gene	1.00
Inflammation	associated_with	disease	1.00
PI3K	activates	gene	1.00
Insulin Resistance	activates	disease	1.00
IL-6	activates	gene	1.00

Incoming (1703)

Source	Relation	Type	Str
mechanisms-metal-ion-toxicity	describes	wiki	1.00
PINK1	activates	gene	1.00
MITOPHAGY	activates	gene	1.00
GPX4	inhibits	gene	1.00
OXIDATIVE STRESS	activates	gene	1.00
SLC7A11	activates	gene	1.00
AUTOPHAGY	activates	gene	1.00
SLC7A11	inhibits	gene	1.00
GPX4	activates	gene	1.00
BAX	activates	gene	1.00
MITOCHONDRIAL DYSFUNCTION	activates	gene	1.00
NEUROINFLAMMATION	activates	gene	1.00
NRF2	activates	gene	1.00
APOPTOSIS	activates	gene	1.00
ATG	associated_with	gene	1.00
Rotenone	upregulates	compound	0.95
ENDOTHELIAL CELLS	activates	cell_type	0.95
celastrol	promotes	compound	0.95
KRAS	activates	gene	0.95
Quercetin	modulates	compound	0.95
Rotenone	upregulates	drug	0.95
Manganese	activates	compound	0.95
FDX1	inhibits	gene	0.90
SOD	downregulates	enzyme	0.90
ETC subunits	causes	protein_complex	0.90
PGC1Α	regulates	entity	0.90
NAC	inhibits	drug	0.90
SLC7A11	downregulates	gene	0.90
NADPH	activates	gene	0.90
Nac	inhibits	compound	0.90
DNA	disrupts	gene	0.90
Autophagy	downregulates	process	0.90
TNF-Α	activates	gene	0.90
AUTOPHAGY	associated_with	gene	0.90
OXIDATIVE STRESS	therapeutic_target	gene	0.90
GPX4	associated_with	gene	0.90
PI3K	activates	gene	0.90
116B	associated_with	compound	0.88
HSPA5	inhibits	entity	0.85
AKT	modulates	protein	0.85
ROS	encodes	gene	0.85
Reductive Stress Response	regulates	pathway	0.85
Ulva Sp.	inhibits	drug	0.85
MITOPHAGY	regulates	pathway	0.84
AUTOPHAGY	inhibits	pathway	0.84
MITOPHAGY	inhibits	pathway	0.84
NRF2	regulates	entity	0.80
autophagy	inhibits	pathway	0.80
rapamycin	targets	drug	0.80
NLR	regulates	gene	0.80

Targeting Hypotheses (30)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
TREM2-Mediated Astrocyte-Microglia Crosstalk in Neurodegener	0.892	neurodegeneration	Gene expression changes in aging mouse b
Alpha-gamma cross-frequency coupling enhancement to restore	0.775	Alzheimer's disease	Circuit-level neural dynamics in neurode
TREM2-CSF1R Cross-Talk in Microglial Metabolic Reprogramming	0.748	neurodegeneration	Gene expression changes in aging mouse b
APOE Isoform Expression Across Glial Subtypes	0.743	Alzheimer's Disease	SEA-AD Gene Expression Profiling — Allen
TREM2 Crosstalk and Synergistic Activation of Phagocytic Tra	0.740	neuroinflammation	What molecular mechanisms mediate SPP1-i

NRF2 failure lowers antioxidant reserve and permits recurren	0.740	neurodegeneration	What mechanisms drive the self-amplifyin
VPS35 retromer activation prevents endosomal tau templating	0.740	neurodegeneration	Which tau propagation mechanism predomin
TREM2 Agonism to Restore Microglial Phagocytosis Across Both	0.735	neurodegeneration	Why have anti-Aβ clinical trials failed
NRF2 Activation Provides Neuroprotection Across ALS, AD, and	0.710	neurodegeneration	Test Preregistration Analysis
TREM2-Mediated Astrocyte-Microglia Cross-Talk in Neurodegene	0.708	neurodegeneration	Gene expression changes in aging mouse b
TREM2-ASM Crosstalk in Microglial Lysosomal Senescence	0.705	neurodegeneration	Gene expression changes in aging mouse b
Mitochondrial-Nuclear Epigenetic Cross-Talk Restoration	0.701	neurodegeneration	Epigenetic reprogramming in aging neuron
Cross-Seeding Prevention Strategy	0.689	neurodegeneration	RNA binding protein dysregulation across
Microglial NOX2 establishes an inflammatory ROS propagation	0.680	neurodegeneration	What mechanisms drive the self-amplifyin
Soluble LRP1 (sLRP1) Ectodomain Shedding as a Blood-Based In	0.680	-	What blood-brain barrier permeability ch
TREM2-Dependent Astrocyte-Microglia Cross-talk in Neurodegen	0.680	neurodegeneration	TREM2 in Alzheimer's Disease: Mechanisms
Stathmin-2 Splice Switching to Prevent Axonal Degeneration A	0.664	neurodegeneration	RNA binding protein dysregulation across
CX3CR1 Promoter Methylation Disrupts Neuron-Microglia Cross-	0.649	developmental neurobiology	Do perinatal immune challenges create pe
p62 Liquid-Liquid Phase Separation Nucleates Cross-Organelle	0.649	neurodegeneration	How do different organelle-specific auto
TREM2-Mediated Astrocyte-Microglia Cross-Talk in Neurodegene	0.642	neurodegeneration	Gene expression changes in aging mouse b
Targeting Bacterial Curli Fibrils to Prevent α-Synuclein Cro	0.642	neurodegeneration	What are the mechanisms by which gut mic
Mitochondrial ROS from complex I and cardiolipin instability	0.640	neurodegeneration	What mechanisms drive the self-amplifyin
Heterogeneous astrocyte activation states differentially imp	0.640	Alzheimer's disease	SEA-AD Single-Cell Analysis: Cell-Type V
Transglutaminase-2 Cross-Linking Inhibition Strategy	0.639	neurodegeneration	Protein aggregation cross-seeding across
TREM2-Mediated Astrocyte-Microglia Cross-Talk in Neurodegene	0.625	neurodegeneration	Gene expression changes in aging mouse b
Cross-Cell Type Synaptic Rescue via Tripartite Synapse Resto	0.620	neurodegeneration	Cell type vulnerability in Alzheimer's D
Low Complexity Domain Cross-Linking Inhibition	0.617	neurodegeneration	TDP-43 phase separation therapeutics for
Tau Cross-Seeding and Interaction	0.610	neurodegeneration	What mechanisms underlie TDP-43's contri
c-Abl Tyrosine Kinase Activation Drives α-Synuclein Phosphor	0.605	neurodegeneration	Legacy Pre-Pipeline Hypothesis Import
Rutin reduces ROS- and metal-driven tau oligomer nucleation	0.602	neurodegeneration	What is the molecular mechanism by which

Mentioning Analyses (4)

Scientific analyses that reference this entity

Oxidative Stress Upstream of TDP-43 Mislocalization in ALS Motor Neurons

neurodegeneration | 2026-04-27 | 0 hypotheses

Epigenetic clocks as biomarkers for Alzheimer disease and neurodegeneration

neurodegeneration | 2026-04-25 | 6 hypotheses Top: 0.387

Proteomics Differential Expression in AD CSF and Brain Tissue

neurodegeneration | 2026-04-16 | 1 hypotheses Top: 0.865

Metabolomic signatures of neurodegeneration and energy metabolism dysfunction

neurodegeneration | 2026-04-04 | 0 hypotheses

Experiments (11)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Model	Status	Est. Cost
GWAS of plasma NfL in East Asian cohort	exploratory	Alzheimer's disease	0.950	human patients - East Asian co	proposed	N/A
GWAS of plasma pTau217 in East Asian cohort	exploratory	Alzheimer's disease	0.950	human patients - East Asian co	proposed	N/A
Dairy intake and dementia risk in Malmö Diet and Cancer cohort	clinical	Alzheimer's disease	0.950	Swedish community-based adults	proposed	N/A
GWAS of plasma pTau181 in East Asian cohort	exploratory	Alzheimer's disease	0.950	human patients - East Asian co	proposed	N/A
GWAS of plasma GFAP in East Asian cohort	exploratory	Alzheimer's disease	0.950	human patients - East Asian co	proposed	N/A
GWAS of composite biomarker score	exploratory	Alzheimer's disease	0.900	human patients - East Asian co	proposed	N/A
Transcriptomic profiling and differential expression analysis	exploratory	Alzheimer's disease	0.900	1-month-old APP/PS1 mice cereb	proposed	N/A
AhR agonist effects on NEP expression in N2a cells	exploratory	Alzheimer's disease	0.900	N2a cells	proposed	N/A
HDAC4 inhibition and NHE6 expression mechanism study	exploratory	Alzheimer's disease	0.850		proposed	N/A
CD2AP expression and cognitive decline in AD patients	exploratory	Alzheimer's disease	0.800	human patients	proposed	N/A
E2F coordination of G2/M transcriptional program	exploratory		0.750	endocycling mammalian cells	proposed	N/A

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
The APOE-R136S mutation protects against APOE4-driven Tau pathology, neurodegene [PMID:37957317]	Maxine R Nelson, Peng Liu, Ayushi Agrawa	Nature neuroscience	2023	1
APOE and Alzheimer's disease: advances in genetics, pathophysiology, and therape [PMID:33340485]	Serrano-Pozo A, Das S, Hyman BT	Lancet Neurol	2021	1
Alzheimer Disease: An Update on Pathobiology and Treatment Strategies. [PMID:31564456]	Long JM, Holtzman DM	Cell	2019	1
Apolipoprotein E and Alzheimer disease: pathobiology and targeting strategies. [PMID:31367008]	Yamazaki Y, Zhao N, Caulfield TR, Liu CC	Nat Rev Neurol	2019	1
Perioperative polygenic and APOE-based genetic risk assessment for neurocognitiv [PMID:40562635]	Thedim M, Hu J, Maher M, Wiener-Kronish	Br J Anaesth	2026	0
Increased genetic protection against Alzheimer's disease in centenarians. [PMID:40615639]	Bae H, Song Z, Ali A, Sasaki T, Tesi N e	Geroscience	2026	0
Integrative machine learning approach to risk prediction for dementia and Alzhei [PMID:40864401]	Stern A, Linial M	Geroscience	2026	0
Adipose Tissue Macrophage-Derived Proplatelet Basic Protein Exacerbates Psoriasi [PMID:40886963]	Zhu L, Du L, Wu J, Ding D, Wang J et al.	J Invest Dermatol	2026	0
Targeting KAT8 alleviates vascular senescence by modulating the INHBA/TGF-β path [PMID:41445196]	Lin Z, Xiong J, Zhang F, Zhang H, Zhu M	Mol Ther	2026	0
Extracellular vesicles from IPFP-MSCs trigger osteoarthritis by transferring mtD [PMID:41480405]	Li S, Yan Z, Zhi X, Zheng W, Zhang Z et	Bioact Mater	2026	0
Menopause, cognition, and Alzheimer's disease risk. [PMID:41531227]	Samudra N, Vemuri M, Weitlauf J	Curr Opin Obstet Gynecol	2026	0
Comprehensive multi-omics analysis and experimental validation indicate that VPS [PMID:41531939]	Wan D, Qi Y, Kang Y, Liang F, Wang Q et	RSC Med Chem	2026	0
Update on genetics of familial hypercholesterolemia. [PMID:41703706]	Freiberger T	Curr Opin Lipidol	2026	0
Integrated Bioinformatics Analysis of Screen Mitochondrial Autophagy-Related Cor [PMID:41731906]	Gao Z, Wang Y, Ren Y, Lyu J	J Neurochem	2026	0
VPS35 Deficiency Markedly Reduces the Proliferation of HEK293 Cells. [PMID:41751560]	Lee S, Park S, Bang H, Kim SU, Park YH e	Genes (Basel)	2026	0
N-acetyl-l-leucine lowers α-synuclein levels and improves synaptic function in P [PMID:41766663]	Song P, Chen C, Franchini R, Duong B, Wa	J Clin Invest	2026	0
The VPS35 protein and the role of its impairments in mitochondrial dysfunction i [PMID:41841708]	Buneeva OA, Medvedev AE	Biomed Khim	2026	0
Vps35 p. D620N causes Lrrk2 kinase hyperactivity, chronic microglial activation [PMID:41846978]	Deng IB, Bu M, Follett J, Sharp R, Mamai	bioRxiv	2026	0
Lack of Cerebrospinal Fluid α-Synuclein Seeding in VPS35 D620N- and LRRK2 Y1699C [PMID:41912440]	Santinelli L, Pratuseviciute N, Lange LM	Mov Disord	2026	0
Neuropsychiatric symptoms and apolipoprotein E genotypes in neurocognitive disor [PMID:40145985]	Lozupone M, Leccisotti I, Mollica A, Ber	Neural regeneration research	2026	0

Debates (5)

Multi-agent debates referencing this entity

Can targeting oxidative stress pathways (NRF2, SOD1, mitochondrial ROS) upstream

active · Rounds: 6 · Score: 0.62 · 2026-04-27

Epigenetic clocks as biomarkers for Alzheimer disease and neurodegeneration

completed · Rounds: 5 · Score: 0.50 · 2026-04-25

How do metabolomic alterations in glucose metabolism, mitochondrial function, an

closed · Rounds: 4 · Score: 0.30 · 2026-04-21

Which proteins are differentially expressed in AD CSF and brain tissue, and do t

closed · Rounds: 4 · Score: 0.70 · 2026-04-21

Is a 12-protein CSF panel superior to existing plasma p-tau217 for clinical AD p

closed · Rounds: 4 · Score: 0.70 · 2026-04-16

Related Research

Hypotheses and analyses mentioning ROS in their description or question text

ROS

Understanding Entity Pages

Summary

Wiki Pages (9)

Mitochondrial Dysfunction Hub

FNP-223 PROSPER Trial - Phase 2 in Progressive Supranuclear Palsy

Reactive Oxygen Species (ROS) Pathway

FNP-223 PROSPER Trial - Phase 2 in Progressive Supranuclear Palsy

PROSAP1 - Proline-Rich Synaptic-Associated Protein 1 (SHANK2)

PROS1 — Protein S (Vitamin K-Dependent Protein S)

Religious Orders Study and Memory and Aging Project (ROS/MAP)

Reactive Oxygen Species (ROS)

Reactive Oxygen Species (ROS)

Pathway Diagram

Outgoing (2535)

Incoming (1703)

Targeting Hypotheses (30)

Mentioning Analyses (4)

Oxidative Stress Upstream of TDP-43 Mislocalization in ALS Motor Neurons

Epigenetic clocks as biomarkers for Alzheimer disease and neurodegeneration

Proteomics Differential Expression in AD CSF and Brain Tissue

Metabolomic signatures of neurodegeneration and energy metabolism dysfunction

Experiments (11)

Related Papers (20)

Debates (5)

Can targeting oxidative stress pathways (NRF2, SOD1, mitochondrial ROS) upstream

Epigenetic clocks as biomarkers for Alzheimer disease and neurodegeneration

How do metabolomic alterations in glucose metabolism, mitochondrial function, an

Which proteins are differentially expressed in AD CSF and brain tissue, and do t

Is a 12-protein CSF panel superior to existing plasma p-tau217 for clinical AD p

Related Research

NRF2 failure lowers antioxidant reserve and permits recurrent mitochondrial ROS

VPS35 retromer activation prevents endosomal tau templating across all brain reg

TREM2 Agonism to Restore Microglial Phagocytosis Across Both Pathologies

NRF2 Activation Provides Neuroprotection Across ALS, AD, and PD

TREM2-Mediated Astrocyte-Microglia Cross-Talk in Neurodegeneration

TREM2-ASM Crosstalk in Microglial Lysosomal Senescence

Mitochondrial-Nuclear Epigenetic Cross-Talk Restoration

Cross-Seeding Prevention Strategy

Microglial NOX2 establishes an inflammatory ROS propagation loop around vulnerab

Soluble LRP1 (sLRP1) Ectodomain Shedding as a Blood-Based Indicator of Impaired

TREM2-Dependent Astrocyte-Microglia Cross-talk in Neurodegeneration

Stathmin-2 Splice Switching to Prevent Axonal Degeneration Across the ALS-FTD-AD

CX3CR1 Promoter Methylation Disrupts Neuron-Microglia Cross-Talk

p62 Liquid-Liquid Phase Separation Nucleates Cross-Organelle Cargo for Coordinat

TREM2-Mediated Astrocyte-Microglia Cross-Talk in Neurodegeneration