concept

P300

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about P300: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

54Connections

0Hypotheses

0Analyses

24Outgoing

30Incoming

0Experiments

0Debates

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💡 Concept Info

Name	P300
Key Genes/Proteins	ACETYL_COA, AEP, AMPK, APP, ASC1, BDNF
Related Diseases	ALS, CHROMATIN REMODELING
Related Pathways	autophagy pathway

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    P300[P300]
    P300 -->|phosphorylates| NCL[NCL]
    P300 -->|regulates| H3K9la[H3K9la]
    P300 -->|modifies| raptor[raptor]
    P300 -->|phosphorylates| RPTOR[RPTOR]
    P300 -->|regulates| AUTOPHAGY[AUTOPHAGY]
    P300 -->|regulates| FOXO3[FOXO3]
    P300 -->|inhibits| APP[APP]
    P300 -->|activates| BRD4[BRD4]
    P300 -->|inhibits| METASTASIS[METASTASIS]
    P300 -->|regulates| TFEB[TFEB]
    ACLY[ACLY] -->|activates| P300
    Acetyl_CoA[Acetyl-CoA] -->|activates| P300
    ASC1[ASC1] -->|interacts| P300
    andrographolide[andrographolide] -->|binds_to| P300
    AMPK[AMPK] -->|inhibits| P300
    TAU[TAU] -->|activates| P300
    BDNF[BDNF] -->|activates| P300
    ALS[ALS] -->|treats| P300
    LACTATE[LACTATE] -->|activates| P300

Outgoing (24)

Target	Relation	Type	Str
NCL	phosphorylates	protein	0.90
H3K9la	regulates	phenotype	0.85
RPTOR	phosphorylates	protein	0.80
raptor	modifies	protein	0.80
AUTOPHAGY	regulates	process	0.80
FOXO3	regulates	gene	0.70
APP	inhibits	gene	0.70
BRD4	activates	gene	0.65
METASTASIS	inhibits	phenotype	0.65
TFEB	regulates	gene	0.60
epigenetic regulation	participates_in	pathway	0.60
autophagy pathway	participates_in	pathway	0.60
oxidative stress response	participates_in	pathway	0.60
lipid metabolism	participates_in	pathway	0.60
macrophages	expressed_in	cell_type	0.60
LONG-TERM POTENTIATION	inhibits	phenotype	0.60
SIRT1	interacts_with	gene	0.60
DNA METHYLATION	activates	phenotype	0.60
AUTOPHAGY	destabilizes	phenotype	0.60
CHROMATIN REMODELING	causes	phenotype	0.60
RAPTOR	regulates	protein	0.56
LONG-TERM POTENTIATION	implicated_in	phenotype	0.55
cholinergic neurons	expressed_in	cell_type	0.55
ALS	associated_with	disease	0.50

Incoming (30)

Source	Relation	Type	Str
ACLY	activates	protein	0.90
Acetyl-CoA	activates	compound	0.85
ASC1	interacts_with	protein	0.80
andrographolide	binds_to	drug	0.80
AMPK	inhibits	protein	0.80
ALS	treats	disease	0.70
BDNF	activates	gene	0.70
BDNF	regulates	gene	0.70
TAU	activates	protein	0.70
LACTATE	activates	phenotype	0.65
AMPK	causes	gene	0.65
ACETYL_COA	activates	protein	0.64
CBP	regulates	gene	0.60
EP300	interacts_with	gene	0.60
CBP	interacts_with	gene	0.60
HDAC1	regulates	gene	0.60
HDAC2	regulates	gene	0.60
HDAC3	regulates	gene	0.60
BRD4	regulates	gene	0.60
BRD4	activates	gene	0.60
DNA METHYLATION	regulates	phenotype	0.60
CREB	interacts_with	gene	0.60
LDL	regulates	gene	0.60
CREB	regulates	gene	0.60
FH	associated_with	gene	0.60
AEP	regulates	gene	0.60
HIPPOCAMPUS	associated_with	brain_region	0.45
PARKINSON	associated_with	disease	0.45
RAPAMYCIN	associated_with	drug	0.45
STROKE	associated_with	disease	0.45

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning P300 in their description or question text

No additional research found