gene

MAP3K5

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MAP3K5: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

287Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

Page for MAP3K5 — Mitogen-Activated Protein Kinase Kinase Kinase 5

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🧬 Gene Info

Gene Symbol	MAP3K5
Full Name	Mitogen-Activated Protein Kinase Kinase Kinase 5
Chromosome	6q26
Protein Type	Kinase
Function	is a critical MAP3K that activates the JNK and p38 MAPK pathways in response to cellular stress.
Molecular Weight	155 kDa
Amino Acids	374 aa
Pathways	MAPK pathway
UniProt ID	[Q9UHD6](https://www.uniprot.org/uniprot/Q9UHD6)
Ensembl ID	ENSG00000197442
OMIM	602476
GeneCards	MAP3K5
Human Protein Atlas	MAP3K5
Cerebral cortex	pyramidal neurons
Hippocampus	CA1-CA3 regions, dentate gyrus
Associated Diseases	neurodegeneration
Known Drugs/Compounds	rapamycin
Interactions	ACOX1, ACTB, Adiponectin, ADIPOQ, AMPK, AND
KG Connections	287 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

MAP3K5 — Mitogen-Activated Protein Kinase Kinase Kinase 5

gene · 1892 words

→

Pathway Diagram

flowchart TD
    MAP3K5["MAP3K5
(ASK1 Kinase)"]
    
    %% Stress Response
    MAP3K5 -->|"activates"| TP53["TP53
(Tumor Suppressor)"]
    MAP3K5 -->|"regulates"| H2AX["H2AX
(DNA Damage Response)"]
    MAP3K5 -->|"interacts_with"| NFE2L2["NFE2L2
(Nrf2 Antioxidant)"]
    
    %% Autophagy Regulation
    MAP3K5 -->|"regulates"| Autophagy["Autophagy
Pathway"]
    MAP3K5 -->|"regulates"| BECN1["BECN1
(Autophagy Initiator)"]
    MAP3K5 -->|"regulates"| ATG14["ATG14
(Autophagy Complex)"]
    MAP3K5 -->|"interacts_with"| MTOR["MTOR
(Growth Regulator)"]
    MTOR -->|"inhibits"| Autophagy
    
    %% Protein Quality Control
    MAP3K5 -->|"regulates"| UPS["Ubiquitin-Proteasome
System"]
    MAP3K5 -->|"regulates"| Proteasome["Proteasome
Pathway"]
    MAP3K5 -->|"associated_with"| LAMP1["LAMP1
(Lysosomal Marker)"]
    
    %% Mitochondrial Function
    MAP3K5 -->|"interacts_with"| SIRT3["SIRT3
(Mitochondrial Deacetylase)"]
    MAP3K5 -->|"interacts_with"| HTRA2["HTRA2
(Mitochondrial Protease)"]
    
    %% Cellular Outcomes
    TP53 -->|"leads_to"| Apoptosis["Cell Death
(Apoptosis)"]
    Autophagy -->|"promotes"| Neuroprotection["Neuroprotection
(Protein Clearance)"]
    UPS -->|"promotes"| Neuroprotection
    
    %% Pathological Processes
    MAP3K5 -->|"contributes_to"| Neurodegeneration["Neurodegeneration
(Disease State)"]
    H2AX -->|"indicates"| DNADamage["DNA Damage
(Cellular Stress)"]
    DNADamage -->|"leads_to"| Neurodegeneration
    
    style MAP3K5 fill:#006494
    style NFE2L2 fill:#1b5e20
    style SIRT3 fill:#1b5e20
    style Autophagy fill:#1b5e20
    style Neuroprotection fill:#1b5e20
    style TP53 fill:#4a1a6b
    style MTOR fill:#4a1a6b
    style BECN1 fill:#4a1a6b
    style Apoptosis fill:#ef5350
    style Neurodegeneration fill:#ef5350
    style DNADamage fill:#ef5350
    style UPS fill:#5d4400
    style Proteasome fill:#5d4400

Outgoing (163)

Target	Relation	Type	Str
autophagy pathway	participates_in	pathway	0.70
Hepatitis	interacts_with	disease	0.65
Tumor	interacts_with	disease	0.65
Als	activates	disease	0.65
RAC1	activates	entity	0.60
SQSTM1	activates	entity	0.60
STK11	activates	entity	0.60
TUBB3	activates	entity	0.60
TUBULIN	activates	entity	0.60
UBIQUITIN	activates	entity	0.60
UVRAG	activates	entity	0.60
VIM	activates	entity	0.60
VIMENTIN	activates	entity	0.60
complement cascade	participates_in	pathway	0.60
Ubiquitin-Proteasome	regulates	pathway	0.60
Autophagy	regulates	pathway	0.60
Proteasome	regulates	pathway	0.60
OCLN	activates	entity	0.60
P62	activates	entity	0.60
PIK3C3	activates	entity	0.60
Apoptosis	activates	pathway	0.60
Mapk	activates	pathway	0.60
TJP1	associated_with	gene	0.60
Phagocytosis	interacts_with	pathway	0.60
Autophagy	interacts_with	pathway	0.60
AMPK	interacts_with	gene	0.60
UVRAG	associated_with	gene	0.60
H2AX	regulates	gene	0.60
OCLN	associated_with	gene	0.60
RAC1	associated_with	gene	0.60
PIK3C3	associated_with	gene	0.60
ATG14	regulates	gene	0.60
GJA1	regulates	gene	0.60
LAMP1	associated_with	gene	0.60
SREBF2	interacts_with	gene	0.60
NFE2L2	interacts_with	gene	0.60
C1Q	interacts_with	gene	0.60
HTRA2	interacts_with	gene	0.60
MTOR	interacts_with	gene	0.60
SIRT3	interacts_with	gene	0.60
PLIN2	interacts_with	gene	0.60
TP53	interacts_with	gene	0.60
NR1H3	interacts_with	gene	0.60
FOXO1	interacts_with	gene	0.60
SQSTM1	interacts_with	gene	0.60
TFEB	interacts_with	gene	0.60
MTOR	activates	entity	0.60
NFE2L2	activates	entity	0.60
NOS3	activates	entity	0.60
NR1H3	activates	entity	0.60

Incoming (124)

Source	Relation	Type	Str
TJP1	associated_with	gene	0.60
AUTOPHAGY	regulates	gene	0.60
LYSOSOME	regulates	gene	0.60
RAS	interacts_with	gene	0.60
CREB	interacts_with	gene	0.60
PHAGOCYTOSIS	interacts_with	gene	0.60
AUTOPHAGY	interacts_with	gene	0.60
MTORC1	interacts_with	gene	0.60
SREBF2	interacts_with	gene	0.60
AND	interacts_with	gene	0.60
RUBCNL	interacts_with	gene	0.60
HTRA2	interacts_with	gene	0.60
P53	interacts_with	gene	0.60
TUBB3	associated_with	gene	0.60
STK11	associated_with	gene	0.60
VIM	associated_with	gene	0.60
BECN1	regulates	gene	0.60
HDAC6	associated_with	gene	0.60
GAPDH	regulates	gene	0.60
MAP1LC3B	associated_with	gene	0.60
TFEB	interacts_with	gene	0.60
MTOR	interacts_with	gene	0.60
P62	interacts_with	gene	0.60
H2AX	regulates	gene	0.60
UVRAG	associated_with	gene	0.60
RAC1	associated_with	gene	0.60
ATG14	regulates	gene	0.60
UBIQUITIN	associated_with	gene	0.60
VIMENTIN	associated_with	gene	0.60
PLIN2	interacts_with	gene	0.60
C1Q	interacts_with	gene	0.60
NFE2L2	interacts_with	gene	0.60
SIRT3	interacts_with	gene	0.60
TP53	interacts_with	gene	0.60
AMPK	activates	entity	0.60
AND	associated_with	gene	0.60
MAPK	activates	gene	0.60
WT1	associated_with	gene	0.60
AR	activates	gene	0.60
CASP3	activates	gene	0.60
GJA1	activates	gene	0.60
ADIPOQ	activates	gene	0.60
ACOX1	interacts_with	gene	0.60
MAP1LC3	interacts_with	gene	0.60
AMPK	interacts_with	gene	0.60
ATG	interacts_with	gene	0.60
APOPTOSIS	activates	gene	0.60
AND	inhibits	gene	0.60
KDM6B	interacts_with	gene	0.60
ATG	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning MAP3K5 in their description or question text

No additional research found