gene

GRK2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GRK2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

167Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

G protein-coupled receptor kinase 2 (GRK2/Beta-ARK1) - role in GPCR desensitization, dopamine signaling, and neurodegenerative diseases including Parkinson's disease.

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🧬 Gene Info

Gene Symbol	GRK2
Full Name	G Protein-Coupled Receptor Kinase 2
Aliases	GRK2/Beta-ARK1
Chromosome	11q13.4
Protein Family	GRK family (PKA/PKG/PKC-like)
Protein Type	Kinase
Function	Receptor Activation — Upon ligand binding, GPCRs undergo conformational changes that enable interaction with heterotrimeric G proteins.
Molecular Weight	80 kDa
Amino Acids	729 aa
Pathways	autophagy pathway, complement cascade, phagocytosis
UniProt ID	[P10147](https://www.uniprot.org/uniprot/P10147)
Ensembl ID	ENSG00000188020
OMIM	109635
GeneCards	GRK2
Human Protein Atlas	GRK2
Associated Diseases	neurodegeneration
Known Drugs/Compounds	rapamycin
Interactions	ACOX1, Adiponectin, ADIPOQ, AMPK, AND, ATG
KG Connections	167 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

GRK2 — G Protein-Coupled Receptor Kinase 2

gene · 1290 words

→

GRK2 Protein — G Protein-Coupled Receptor Kinase 2

protein · 817 words

→

Pathway Diagram

flowchart TD
    GRK2["GRK2"] -->|"interacts with"| Tumor["Tumor"]
    GRK2["GRK2"] -->|"interacts with"| Hepatitis["Hepatitis"]
    GRK2["GRK2"] -->|"interacts with"| FOXO1["FOXO1"]
    GRK2["GRK2"] -->|"interacts with"| NR1H3["NR1H3"]
    GRK2["GRK2"] -->|"interacts with"| MAP3K5["MAP3K5"]
    GRK2["GRK2"] -->|"interacts with"| SREBF2["SREBF2"]
    GRK2["GRK2"] -->|"interacts with"| NFE2L2["NFE2L2"]
    GRK2["GRK2"] -->|"interacts with"| C1Q["C1Q"]
    GRK2["GRK2"] -->|"interacts with"| HTRA2["HTRA2"]
    GRK2["GRK2"] -->|"interacts with"| MTOR["MTOR"]
    GRK2["GRK2"] -->|"interacts with"| SIRT3["SIRT3"]
    GRK2["GRK2"] -->|"interacts with"| PLIN2["PLIN2"]
    style GRK2 fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style Tumor fill:#ef5350,stroke:#333,color:#e0e0e0
    style Hepatitis fill:#ef5350,stroke:#333,color:#e0e0e0
    style FOXO1 fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style NR1H3 fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style MAP3K5 fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style SREBF2 fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style NFE2L2 fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style C1Q fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style HTRA2 fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style MTOR fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style SIRT3 fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style PLIN2 fill:#4a1a6b,stroke:#333,color:#e0e0e0

Outgoing (107)

Target	Relation	Type	Str
Cancer	therapeutic_target	disease	0.65
Tumor	interacts_with	disease	0.65
Hepatitis	interacts_with	disease	0.65
Cancer	activates	disease	0.65
RAS	activates	gene	0.60
RUBCNL	activates	gene	0.60
autophagy pathway	participates_in	pathway	0.60
endothelial cells	expressed_in	cell_type	0.60
Mtor	interacts_with	pathway	0.60
FOXO1	interacts_with	gene	0.60
NR1H3	interacts_with	gene	0.60
MAP3K5	interacts_with	gene	0.60
SREBF2	interacts_with	gene	0.60
NFE2L2	interacts_with	gene	0.60
C1Q	interacts_with	gene	0.60
HTRA2	interacts_with	gene	0.60
MTOR	interacts_with	gene	0.60
SIRT3	interacts_with	gene	0.60
PLIN2	interacts_with	gene	0.60
TP53	interacts_with	gene	0.60
LAMP2	interacts_with	gene	0.60
ULK1	interacts_with	gene	0.60
BECN1	interacts_with	gene	0.60
TFEB	interacts_with	gene	0.60
RPTOR	interacts_with	gene	0.60
Phagocytosis	interacts_with	pathway	0.60
Autophagy	interacts_with	pathway	0.60
App	therapeutic_target	protein	0.60
Adiponectin	interacts_with	protein	0.60
complement cascade	participates_in	pathway	0.60
phagocytosis	activates	process	0.60
AMPK	interacts_with	gene	0.60
MAP1LC3	interacts_with	gene	0.60
CREB	interacts_with	gene	0.60
ACOX1	interacts_with	gene	0.60
P53	interacts_with	gene	0.60
PHAGOCYTOSIS	interacts_with	gene	0.60
RAS	interacts_with	gene	0.60
AUTOPHAGY	interacts_with	gene	0.60
PHAGOCYTOSIS	activates	entity	0.60
ATG	interacts_with	gene	0.60
AND	interacts_with	gene	0.60
Collagen	interacts_with	protein	0.60
KDM6B	interacts_with	gene	0.60
SIRT1	interacts_with	gene	0.60
STX17	interacts_with	gene	0.60
PLIN3	interacts_with	gene	0.60
STING1	interacts_with	gene	0.60
GLP1R	interacts_with	gene	0.60
SREBF1	interacts_with	gene	0.60

Incoming (60)

Source	Relation	Type	Str
RAS	interacts_with	gene	0.60
CREB	interacts_with	gene	0.60
PHAGOCYTOSIS	interacts_with	gene	0.60
AUTOPHAGY	interacts_with	gene	0.60
AMPK	activates	entity	0.60
MTOR	interacts_with	gene	0.60
P62	interacts_with	gene	0.60
FOXO1	interacts_with	gene	0.60
TFEB	interacts_with	gene	0.60
MTORC1	interacts_with	gene	0.60
AND	interacts_with	gene	0.60
RUBCNL	interacts_with	gene	0.60
AND	activates	gene	0.60
CANCER	activates	gene	0.60
ACOX1	activates	gene	0.60
ATG	activates	gene	0.60
CREB	activates	gene	0.60
rapamycin	targets	drug	0.60
KDM6B	interacts_with	gene	0.60
LC3	interacts_with	gene	0.60
RPTOR	interacts_with	gene	0.60
PRKAA2	interacts_with	gene	0.60
LAMP2	interacts_with	gene	0.60
PLIN3	interacts_with	gene	0.60
BECN1	interacts_with	gene	0.60
NR1H3	interacts_with	gene	0.60
MAP3K5	interacts_with	gene	0.60
HTRA2	interacts_with	gene	0.60
ADIPOQ	activates	gene	0.60
PPARA	interacts_with	gene	0.60
ULK1	interacts_with	gene	0.60
STX17	interacts_with	gene	0.60
SQSTM1	interacts_with	gene	0.60
NOS3	interacts_with	gene	0.60
STING1	interacts_with	gene	0.60
GLP1R	interacts_with	gene	0.60
SREBF1	interacts_with	gene	0.60
SIRT1	interacts_with	gene	0.60
TP53	interacts_with	gene	0.60
SIRT3	interacts_with	gene	0.60
PLIN2	interacts_with	gene	0.60
C1Q	interacts_with	gene	0.60
NFE2L2	interacts_with	gene	0.60
SREBF2	interacts_with	gene	0.60
BECN1	activates	entity	0.60
C1Q	activates	entity	0.60
FOXO1	activates	entity	0.60
GLP1R	activates	entity	0.60
ACOX1	interacts_with	gene	0.60
MAP1LC3	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning GRK2 in their description or question text

No additional research found