protein

S6K1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about S6K1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

106Connections

0Hypotheses

0Analyses

50Outgoing

49Incoming

0Experiments

0Debates

Summary

Page for S6K1 Protein

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🔬 Protein Info

Gene Symbol	S6K1
Function	S6K1 Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
Molecular Weight	70 kDa
Pathways	mTOR
GeneCards	S6K1
Human Protein Atlas	S6K1
Associated Diseases	ALS, neurodegeneration
Known Drugs/Compounds	rapamycin
Interactions	ADAM10, AKT, AMPK, AND, APOE, AUTOPHAGY
KG Connections	106 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

S6K1 Protein

protein · 866 words

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Pathway Diagram

graph TD
    S6K1(["S6K1"])
    Inflammation["Inflammation"]
    AKT["AKT"]
    RPTOR["RPTOR"]
    Atherosclerosis["Atherosclerosis"]
    Ischemia["Ischemia"]
    ALS["ALS"]
    Alzheimer["Alzheimer"]
    LDLR["LDLR"]
    AND["AND"]
    MTOR["MTOR"]
    PSAP["PSAP"]
    Oxidative_Phosphorylation["Oxidative Phosphorylation"]
    Mtor["Mtor"]
    Glycolysis["Glycolysis"]
    ADAM10["ADAM10"]
    NEURON["NEURON"]
    S6K1 -->|"regulates"| Inflammation
    AKT -->|"phosphorylates"| S6K1
    RPTOR -->|"regulates"| S6K1
    S6K1 -.->|"inhibits"| Atherosclerosis
    S6K1 -.->|"inhibits"| Inflammation
    S6K1 -->|"activates"| Ischemia
    S6K1 -->|"activates"| ALS
    S6K1 -->|"therapeutic_tar"| Atherosclerosis
    S6K1 -->|"therapeutic_tar"| Alzheimer
    S6K1 -.->|"inhibits"| LDLR
    S6K1 -->|"expressed in"| AND
    S6K1 -->|"expressed in"| MTOR
    S6K1 -.->|"inhibits"| PSAP
    S6K1 -.->|"inhibits"| Oxidative_Phosphorylation
    S6K1 -->|"expressed in"| Mtor
    S6K1 -.->|"inhibits"| Glycolysis
    S6K1 -->|"activates"| ADAM10
    S6K1 -->|"activates"| AND
    S6K1 -->|"activates"| MTOR
    S6K1 -->|"activates"| NEURON
    style S6K1 fill:#006494,stroke:#333,color:#e0e0e0,stroke-width:2px

Outgoing (57)

Target	Relation	Type	Str
Inflammation	regulates	process	0.85
Alzheimer	therapeutic_target	disease	0.65
Atherosclerosis	inhibits	disease	0.65
Autoimmune	activates	disease	0.65
Inflammation	activates	disease	0.65
Ischemia	activates	disease	0.65
ALS	activates	disease	0.65
Senescence	inhibits	disease	0.65
Atherosclerosis	therapeutic_target	disease	0.65
Inflammation	inhibits	disease	0.65
ALS	inhibits	disease	0.65
NEURON	activates	gene	0.60
ERK	activates	gene	0.60
Mtor	activates	pathway	0.60
Glycolysis	therapeutic_target	pathway	0.60
Synaptic Plasticity	therapeutic_target	pathway	0.60
Autophagy	activates	pathway	0.60
Immune Response	activates	pathway	0.60
MITOCHONDRIA	inhibits	gene	0.60
AND	regulates	gene	0.60
MTOR	regulates	gene	0.60
MAPK signaling	participates_in	pathway	0.60
LDLR	inhibits	gene	0.60
AND	expressed_in	gene	0.60
MTOR	expressed_in	gene	0.60
PSAP	inhibits	gene	0.60
Oxidative Phosphorylation	inhibits	pathway	0.60
Mtor	expressed_in	pathway	0.60
Glycolysis	inhibits	pathway	0.60
ADAM10	activates	gene	0.60
AND	activates	gene	0.60
MTOR	activates	gene	0.60
SFN	activates	gene	0.60
TFEB	activates	gene	0.60
TRPML1	activates	gene	0.60
oxidative stress response	participates_in	pathway	0.60
Mtor	regulates	pathway	0.60
ALS	associated_with	disease	0.60
neurodegeneration	associated_with	disease	0.60
PI3K-AKT-mTOR signaling	participates_in	pathway	0.60
INFLAMMATION	inhibits	gene	0.60
BRAIN INJURY	activates	gene	0.60
AKT	activates	gene	0.60
NLGN3	activates	gene	0.60
cancer	activates	disease	0.60
APOE	expressed_in	gene	0.60
Oxidative Phosphorylation	therapeutic_target	pathway	0.60
macrophages	expressed_in	cell_type	0.60
ULK1	inhibits	gene	0.55
autophagy pathway	participates_in	pathway	0.55

Incoming (49)

Source	Relation	Type	Str
AKT	phosphorylates	protein	0.85
RPTOR	regulates	gene	0.80
ROS	activates	gene	0.60
MAPK1	activates	gene	0.60
APOE	expressed_in	gene	0.60
INFLAMMATION	inhibits	gene	0.60
AMPK	activates	gene	0.60
PTEN	activates	gene	0.60
MTOR	expressed_in	gene	0.60
PSAP	therapeutic_target	gene	0.60
LDLR	therapeutic_target	gene	0.60
MTOR	activates	gene	0.60
ERK	activates	gene	0.60
ALZHEIMER	therapeutic_target	gene	0.60
ERK1/2	activates	gene	0.60
APP/PS1	therapeutic_target	gene	0.60
INFLAMMATION	activates	gene	0.60
CYTOKINES	activates	gene	0.60
AUTOPHAGY	activates	gene	0.60
CD4	activates	gene	0.60
AKT	regulates	gene	0.60
AMPK	regulates	gene	0.60
RPS6KB1	activates	gene	0.60
rapamycin	targets	drug	0.60
CAT	activates	gene	0.60
GFP	activates	gene	0.60
HMOX1	activates	gene	0.60
KEAP1	activates	gene	0.60
LAMP1	activates	gene	0.60
MCOLN1	activates	gene	0.60
MTORC1	activates	gene	0.60
NFE2L2	activates	gene	0.60
NRF2	activates	gene	0.60
PP2A	activates	gene	0.60
AKT	activates	gene	0.60
NLGN3	activates	gene	0.60
BRAIN INJURY	activates	gene	0.60
mTOR	activates	entity	0.50
mTOR	interacts_with	entity	0.50
mTOR	regulates	entity	0.50
APOE	inhibits	gene	0.50
mTOR	inhibits	entity	0.50
PP2A	co_expressed_with	gene	0.50
RPS6KB1	co_expressed_with	gene	0.50
ADAM10	co_expressed_with	protein	0.50
NLGN3	co_expressed_with	gene	0.50
PSAP	co_expressed_with	gene	0.50
AKT	co_expressed_with	protein	0.50
AMPK	co_expressed_with	protein	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning S6K1 in their description or question text

No additional research found