gene

SREBF2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SREBF2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

574Connections

1Hypotheses

2Analyses

50Outgoing

50Incoming

0Experiments

2Debates

Summary

Page for SREBF2 — Sterol Regulatory Element Binding Transcription Factor 2

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🧬 Gene Info

Gene Symbol	SREBF2
Full Name	Sterol Regulatory Element Binding Transcription Factor 2
Chromosome	22
Protein Type	Transcription Factor
Target Class	Transcription Factor
Function	SREBF2 plays a critical role in cholesterol metabolism, which is intimately connected to Alzheimer's disease pathogenesis through multiple mechanisms:
Mechanism of Action	Small molecule modulators of transcriptional activity or protein-protein interactions
Druggability	Undruggable (0.20)
Clinical Stage	Phase II
Pathways	Amyloid, Autophagy, Cholesterol, Cholesterol Metabolism, Mitophagy
UniProt ID	A0AA34QVX2
Ensembl ID	ENSG00000198911
GeneCards	SREBF2
Human Protein Atlas	SREBF2
Associated Diseases	Als, Alzheimer, neurodegeneration
Known Drugs/Compounds	rapamycin, RAPAMYCIN
Interactions	ABCA1, ACOX1, Adiponectin, ADIPOQ, AGING, AKT3
SciDEX Target	View Target Profile (8 clinical trials)
SciDEX Hypotheses	APOE4-associated inflammatory signaling amplifies
KG Connections	574 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: SREBF2 — AlphaFold A0AA34QVX2 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

SREBF2 — Sterol Regulatory Element Binding Transcription Factor 2

gene · 604 words

→

SREBF2 Protein — Sterol Regulatory Element Binding Factor 2 (SREBP-2)

protein · 670 words

→

Pathway Diagram

graph TD
    SREBF2["SREBF2"] -->|"associated"| neurodegeneration["neurodegeneration"]
    SREBF2["SREBF2"] -->|"interacts"| ABCA1["ABCA1"]
    SREBF2["SREBF2"] -->|"interacts"| LDLR["LDLR"]
    SREBF2["SREBF2"] -->|"interacts"| Tumor["Tumor"]
    SREBF2["SREBF2"] -->|"interacts"| Hepatitis["Hepatitis"]
    SREBF2["SREBF2"] -->|"regulates"| Alzheimer["Alzheimer"]
    h_9d29bfe5["h-9d29bfe5"] -->|"therapeutic target"| SREBF2["SREBF2"]
    ABCA1_1["ABCA1"] -->|"interacts"| SREBF2["SREBF2"]
    LDLR_2["LDLR"] -->|"interacts"| SREBF2["SREBF2"]
    PPARA["PPARA"] -->|"interacts"| SREBF2["SREBF2"]
    style SREBF2 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (285)

Target	Relation	Type	Str
phospholipid synthesis	activates	biological_process	0.90
fatty acid synthesis	activates	biological_process	0.90
fatty acids	regulates	chemical	0.90
cholesterol	regulates	chemical	0.90
phospholipids	regulates	chemical	0.90
cholesterol homeostasis	regulates	biological_process	0.90
triglyceride synthesis	activates	biological_process	0.90
lipid homeostasis	regulates	biological_process	0.90
triglycerides	regulates	chemical	0.90
cholesterol biosynthesis	activates	biological_process	0.90
neural stem cells	activates	cell_type	0.80
cholesterol biosynthesis	upregulates	biological_process	0.80
NLRP3 inflammasome	activates	entity	0.80
INSIG1	phosphorylates	gene	0.80
neural stem cells	regulates	cell_type	0.80
INSIG2	phosphorylates	gene	0.80
CYP51A1	upregulates	gene	0.80
lipid metabolism	participates_in	pathway	0.70
neurodegeneration	associated_with	disease	0.68
ABCA1	interacts_with	gene	0.68
LDLR	interacts_with	gene	0.68
Cancer	regulates	disease	0.65
Alzheimer	associated_with	disease	0.65
Alzheimer	regulates	disease	0.65
Inflammation	activates	disease	0.65
Frontotemporal Dementia	regulates	disease	0.65
ALS	activates	disease	0.65
ALS	regulates	disease	0.65
Als	activates	disease	0.65
Atherosclerosis	expressed_in	disease	0.65
ALS	associated_with	disease	0.65
Hepatitis	interacts_with	disease	0.65
Als	associated_with	disease	0.65
Alzheimer	activates	disease	0.65
Aging	activates	disease	0.65
Als	regulates	disease	0.65
Tumor	interacts_with	disease	0.65
Ms	regulates	disease	0.65
Amyotrophic Lateral Sclerosis	regulates	disease	0.65
Dementia	regulates	disease	0.65
ALZHEIMER	associated_with	gene	0.60
Aβ	activates	protein	0.60
PLIN2	interacts_with	gene	0.60
Amyloid Beta	activates	protein	0.60
MTOR	interacts_with	gene	0.60
SIRT3	interacts_with	gene	0.60
TP53	interacts_with	gene	0.60
NFE2L2	interacts_with	gene	0.60
C1Q	interacts_with	gene	0.60
neurons	expressed_in	cell_type	0.60

Incoming (289)

Source	Relation	Type	Str
TDP-43	binds	protein	1.00
h-9d29bfe5	targets	hypothesis	0.90
LDLR	expressed_in	gene	0.70
OPTN	interacts_with	gene	0.70
LDLR	interacts_with	gene	0.68
ABCA1	interacts_with	gene	0.68
RAPAMYCIN	activates	drug	0.65
P53	activates	gene	0.65
PINK1	co_discussed	gene	0.60
myelination	regulates	process	0.60
PRKN	co_discussed	gene	0.60
NR1H3	activates	entity	0.60
MAP1LC3	interacts_with	gene	0.60
GLP1R	activates	entity	0.60
LDLR	causes	gene	0.60
PLIN3	activates	entity	0.60
OPTN	co_discussed	gene	0.60
AMPK	interacts_with	gene	0.60
PARKIN	promotes	gene	0.60
PRKN	activates	gene	0.60
PRESENILIN	regulates	gene	0.60
NOS3	activates	entity	0.60
OPTN	protects_against	gene	0.60
TAU	regulates	gene	0.60
OPTINEURIN	interacts_with	gene	0.60
P62	activates	entity	0.60
KDM6B	activates	entity	0.60
PLIN2	activates	entity	0.60
PINK1	promotes	gene	0.60
SREBF1	activates	entity	0.60
LAMP2	activates	entity	0.60
PPARA	activates	entity	0.60
NFE2L2	regulates	gene	0.60
LDLR	regulates	gene	0.60
MAP3K5	activates	entity	0.60
PRKAA2	activates	entity	0.60
TDP-43	regulates	gene	0.60
NFE2L2	activates	entity	0.60
FOXO1	activates	entity	0.60
GRK2	activates	entity	0.60
GSK3B	phosphorylates	protein	0.60
SCAP	interacts_with	protein	0.60
Mitochondrial translation	regulates	pathway	0.60
HTRA2	activates	entity	0.60
OPTINEURIN	activates	gene	0.60
PINK1	activates	gene	0.60
PTEN	activates	gene	0.60
GAIN	associated_with	gene	0.60
EGR1	regulates	gene	0.60
PPARG	regulates	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
APOE4-associated inflammatory signaling amplifies SREBP2 act	0.470	molecular biology	Does APOE4's reduced lipid-binding direc

Mentioning Analyses (2)

Scientific analyses that reference this entity

Cell type vulnerability in Alzheimers Disease (SEA-AD transcriptomic data)

neurodegeneration | 2026-04-03 | 18 hypotheses Top: 0.847

Lipid raft composition changes in synaptic neurodegeneration

neurodegeneration | 2026-04-01 | 12 hypotheses Top: 0.921

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (2)

Multi-agent debates referencing this entity

Investigate how lipid raft composition (cholesterol metabolism, sphingolipids) c

closed · Rounds: 5 · Score: 0.93 · 2026-04-11

What cell types are most vulnerable in Alzheimers Disease based on SEA-AD transc

closed · Rounds: 4 · Score: 0.90 · 2026-04-03

Related Research

Hypotheses and analyses mentioning SREBF2 in their description or question text

No additional research found