SIRT3

Understanding Entity Pages

This page aggregates everything SciDEX knows about SIRT3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

SIRT3 is a gene implicated in neurodegeneration research. Key relationships include: activates, interacts with, regulates. Associated with ALS, ALZHEIMER'S DISEASE, Aging. Connected to 501 entities in the SciDEX knowledge graph.

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flowchart TD
    SIRT3(["SIRT3"])
    Als["Als"]
    Inflammation["Inflammation"]
    Autophagy["Autophagy"]
    Oxidative_Stress["Oxidative Stress"]
    MITOCHONDRIAL_DYSFUNCTION(["MITOCHONDRIAL DYSFUNCTION"])
    MITOCHONDRIA(["MITOCHONDRIA"])
    mitophagy["mitophagy"]
    Mitochondrial_Autophagy("Mitochondrial Autophagy")
    h_0e614ae4["h-0e614ae4"]
    Honokiol["Honokiol"]
    Mitophagy["Mitophagy"]
    SIRT1(["SIRT1"])
    AMPK(["AMPK"])
    INFLAMMATION(["INFLAMMATION"])

    SIRT3 -->|"activates"| Als
    SIRT3 -->|"activates"| Inflammation
    SIRT3 -->|"activates"| Autophagy
    SIRT3 -->|"activates"| Oxidative_Stress
    SIRT3 -->|"activates"| MITOCHONDRIAL_DYSFUNCTION
    SIRT3 -->|"activates"| MITOCHONDRIA
    SIRT3 -->|"activates"| mitophagy
    SIRT3 -->|"mediates"| Mitochondrial_Autophagy
    h_0e614ae4 -->|"therapeutic target"| SIRT3
    Honokiol -->|"activates"| SIRT3
    h_0e614ae4 -->|"targets gene"| SIRT3
    SIRT3 -->|"activates"| Mitophagy
    SIRT3 -->|"expressed in"| SIRT1
    SIRT3 -->|"activates"| AMPK
    SIRT3 -->|"activates"| INFLAMMATION

    style SIRT3 fill:#006494,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0