gene

PLIN3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PLIN3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

206Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

PLIN3 is a gene implicated in neurodegeneration research. Key relationships include: interacts with, activates, associated with. Associated with Hepatitis, Neurodegeneration, Tumor. Connected to 91 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	PLIN3
Function	encodes a lipid droplet-associated protein that plays crucial roles in lipid metabolism, autophagy regulation, and lysosomal function.
Primary Expression	various tissues with specific patterns:
Molecular Weight	47 kDa
Pathways	autophagy pathway, Phagocytosis, Mtor, Autophagy, complement cascade
Ensembl ID	ENSG00000138326
GeneCards	PLIN3
Human Protein Atlas	PLIN3
Coats lipid droplet surface	Forms a monomolecular layer on the droplet surface
Regulates size	Controls lipid droplet growth and coalescence
Prevents lipolysis	Protects stored triglycerides from ATGL-mediated hydrolysis
Recruits proteins	Attracts lipases and other regulatory proteins
Lipid droplet recognition	PLIN3 marks droplets for selective autophagy
Autophagosome recruitment	Facilitates LC3 binding to lipid droplets
Lysosomal fusion	Coordinates droplet delivery to lysosomes
Associated Diseases	neurodegeneration
Known Drugs/Compounds	rapamycin
Interactions	ACOX1, Adiponectin, ADIPOQ, AMPK, AND, ASTROCYTES
KG Connections	206 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

plin3

gene · 1408 words

→

Pathway Diagram

flowchart TD
    PLIN3["PLIN3"] -->|"interacts with"| Tumor["Tumor"]
    PLIN3["PLIN3"] -->|"interacts with"| Hepatitis["Hepatitis"]
    PLIN3["PLIN3"] -->|"interacts with"| BECN1["BECN1"]
    PLIN3["PLIN3"] -->|"interacts with"| GRK2["GRK2"]
    PLIN3["PLIN3"] -->|"interacts with"| FOXO1["FOXO1"]
    PLIN3["PLIN3"] -->|"interacts with"| NR1H3["NR1H3"]
    PLIN3["PLIN3"] -->|"interacts with"| MAP3K5["MAP3K5"]
    PLIN3["PLIN3"] -->|"interacts with"| SREBF2["SREBF2"]
    PLIN3["PLIN3"] -->|"interacts with"| NFE2L2["NFE2L2"]
    PLIN3["PLIN3"] -->|"interacts with"| C1Q["C1Q"]
    PLIN3["PLIN3"] -->|"interacts with"| HTRA2["HTRA2"]
    PLIN3["PLIN3"] -->|"interacts with"| MTOR["MTOR"]
    style PLIN3 fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style Tumor fill:#ef5350,stroke:#333,color:#e0e0e0
    style Hepatitis fill:#ef5350,stroke:#333,color:#e0e0e0
    style BECN1 fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style GRK2 fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style FOXO1 fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style NR1H3 fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style MAP3K5 fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style SREBF2 fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style NFE2L2 fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style C1Q fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style HTRA2 fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style MTOR fill:#4a1a6b,stroke:#333,color:#e0e0e0

Outgoing (112)

Target	Relation	Type	Str
autophagy pathway	participates_in	pathway	0.70
Tumor	interacts_with	disease	0.65
Hepatitis	interacts_with	disease	0.65
Neurodegeneration	inhibits	disease	0.65
Neurodegeneration	associated_with	disease	0.65
MTORC1	interacts_with	gene	0.60
AMPK	interacts_with	gene	0.60
MAP1LC3	interacts_with	gene	0.60
CREB	interacts_with	gene	0.60
ACOX1	interacts_with	gene	0.60
P53	interacts_with	gene	0.60
PHAGOCYTOSIS	interacts_with	gene	0.60
RAS	interacts_with	gene	0.60
AUTOPHAGY	interacts_with	gene	0.60
ATG	interacts_with	gene	0.60
FURIN	associated_with	gene	0.60
MAP1LC3	activates	gene	0.60
ASTROCYTES	activates	gene	0.60
LIPOPHAGY	associated_with	gene	0.60
Endothelial	interacts_with	cell_type	0.60
ITGAV	associated_with	gene	0.60
Astrocyte	activates	cell_type	0.60
LC3	activates	gene	0.60
LAMP1	activates	gene	0.60
P62	interacts_with	gene	0.60
Adiponectin	interacts_with	protein	0.60
TFEB	activates	entity	0.60
BECN1	interacts_with	gene	0.60
GRK2	interacts_with	gene	0.60
FOXO1	interacts_with	gene	0.60
NR1H3	interacts_with	gene	0.60
MAP3K5	interacts_with	gene	0.60
SREBF2	interacts_with	gene	0.60
NFE2L2	interacts_with	gene	0.60
C1Q	interacts_with	gene	0.60
HTRA2	interacts_with	gene	0.60
MTOR	interacts_with	gene	0.60
SIRT3	interacts_with	gene	0.60
PLIN2	interacts_with	gene	0.60
TP53	interacts_with	gene	0.60
STING1	interacts_with	gene	0.60
GLP1R	interacts_with	gene	0.60
SREBF1	interacts_with	gene	0.60
NOS3	interacts_with	gene	0.60
LC3	interacts_with	gene	0.60
PRKAA2	interacts_with	gene	0.60
RPTOR	interacts_with	gene	0.60
SQSTM1	interacts_with	gene	0.60
PPARA	interacts_with	gene	0.60
LAMP2	interacts_with	gene	0.60

Incoming (94)

Source	Relation	Type	Str
ASTROCYTES	activates	gene	0.60
PLIN2	interacts_with	gene	0.60
LAMP1	activates	gene	0.60
ADIPOQ	activates	gene	0.60
ABCA7	regulates	gene	0.60
RAS	interacts_with	gene	0.60
PHAGOCYTOSIS	interacts_with	gene	0.60
FURIN	associated_with	gene	0.60
LIPOPHAGY	associated_with	gene	0.60
AND	activates	gene	0.60
MTORC1	interacts_with	gene	0.60
AUTOPHAGY	interacts_with	gene	0.60
AND	interacts_with	gene	0.60
ITGAV	inhibits	gene	0.60
LIPOPHAGY	inhibits	gene	0.60
FURIN	inhibits	gene	0.60
CREB	interacts_with	gene	0.60
RUBCNL	interacts_with	gene	0.60
ACOX1	activates	gene	0.60
ATG	activates	gene	0.60
CREB	activates	gene	0.60
MAP1LC3	activates	gene	0.60
MTORC1	activates	gene	0.60
rapamycin	targets	drug	0.60
MAP1LC3	biomarker_for	gene	0.60
PKM2	regulates	gene	0.60
AMPK	activates	entity	0.60
PHAGOCYTOSIS	activates	entity	0.60
NEURODEGENERATION	associated_with	gene	0.60
ULK1	interacts_with	gene	0.60
STX17	interacts_with	gene	0.60
SQSTM1	interacts_with	gene	0.60
NOS3	interacts_with	gene	0.60
STING1	interacts_with	gene	0.60
GLP1R	interacts_with	gene	0.60
SREBF1	interacts_with	gene	0.60
SIRT1	interacts_with	gene	0.60
KDM6B	interacts_with	gene	0.60
LC3	interacts_with	gene	0.60
RPTOR	interacts_with	gene	0.60
PRKAA2	interacts_with	gene	0.60
LAMP2	interacts_with	gene	0.60
FOXO1	interacts_with	gene	0.60
TFEB	interacts_with	gene	0.60
MTOR	interacts_with	gene	0.60
P62	interacts_with	gene	0.60
NR1H3	interacts_with	gene	0.60
MAP3K5	interacts_with	gene	0.60
BECN1	interacts_with	gene	0.60
HTRA2	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PLIN3 in their description or question text

No additional research found