gene

C1Q

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about C1Q: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1595Connections

13Hypotheses

24Analyses

50Outgoing

50Incoming

13Experiments

20Debates

Summary

C1Q is a gene implicated in neurodegeneration research. Key relationships include: activates, associated with, interacts with. Associated with AD, ALI, ALS. Connected to 856 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	C1QA
Full Name	Complement Component 1, Q Subunit A
Chromosome	1p36.33
Protein Type	Signaling Protein
Target Class	Signaling Protein
Function	The C1QA gene encodes the A-chain of complement component C1q.
Mechanism of Action	Complement cascade inhibitor or antibody-mediated neutralization
Primary Expression	Primarily expressed in myeloid cells (monocytes, macrophages, microglia); astrocytic expression detected in disease states
Subcellular Localization	synapses, dystrophic neurites, extracellular protein aggregates, and vascular interfaces. These features make C1QA a hig
Druggability	Low (0.41)
Clinical Stage	Phase II
Amino Acids	245 aa
Pathways	Complement, Complement system, Synaptic pruning, complement activation
UniProt ID	P02787
NCBI Gene ID	712
Ensembl ID	ENSG00000196954
OMIM	120550
GeneCards	C1QA
Human Protein Atlas	C1QA
Associated Diseases	AD, Aging, ALI, Als, Alzheimer
Known Drugs/Compounds	ANX005
Interactions	AIF1, ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, AND, ANXIETY
SciDEX Target	View Target Profile (7 clinical trials)
SciDEX Hypotheses	Complement C1q Mimetic Decoy Therapy Complement C1QA Spatial Gradient in Cortical Layer Complement C1q Subtype Switching (+3 more)
KG Connections	730 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: C1Q — AlphaFold P02745 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (7)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    C1Q["C1Q"] -->|"associated"| neurodegeneration["neurodegeneration"]
    C1Q["C1Q"] -->|"interacts"| C3["C3"]
    C1Q["C1Q"] -->|"co discussed"| NAMPT["NAMPT"]
    C1Q["C1Q"] -->|"co discussed"| GPX4["GPX4"]
    C1Q["C1Q"] -->|"co discussed"| PLA2G6["PLA2G6"]
    C1Q["C1Q"] -->|"co discussed"| MMP2["MMP2"]
    C3_1["C3"] -->|"interacts"| C1Q["C1Q"]
    MMP9["MMP9"] -->|"co discussed"| C1Q["C1Q"]
    SLC7A11["SLC7A11"] -->|"co discussed"| C1Q["C1Q"]
    AQP4["AQP4"] -->|"co discussed"| C1Q["C1Q"]
    style C1Q fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (1139)

Target	Relation	Type	Str
PHAGOCYTOSIS	activates	phenotype	1.00
phagocytosis	activates	phenotype	1.00
Complement	activates	pathway	1.00
Als	associated_with	disease	1.00
CR3	signals_through	receptor	1.00
MICROGLIA	activates	cell_type	1.00
Alzheimer's Disease	mediates	disease	0.95
A1 Astrocytes	associated_with	phenotype	0.95
Atherosclerosis	risk_factor_for	disease	0.95
Reactive Astrocytes	activates	cell_type	0.95
Synapse Loss	mediates	phenotype	0.95
Inflammation	activates	disease	0.95
C3-Cr3 Signaling Pathway	activates	pathway	0.95
Microglial Phagocytosis	mediates	process	0.95
A1 Reactive Astrocytes	associated_with	phenotype	0.95
Trained Immunity	modulates	process	0.95
ATHEROSCLEROSIS	associated_with	entity	0.95
Tumor-Associated Macrophages	expressed_in	cell_type	0.95
Alzheimer	activates	disease	0.95
Tumor	associated_with	disease	0.95
Alzheimer'S Disease	involved_in	disease	0.92
Complement system	associated_with	pathway	0.90
Classical complement pathway	activates	pathway	0.90
Classical Complement Cascade	activates	pathway	0.90
DOR	binds	protein	0.90
Alectinib	binds	drug	0.90
Microglial Phagocytosis Of Synapses	regulates	process	0.90
Myeloid Cell Metabolism	associated_with	process	0.90
β-Amyloid Oligomer Toxicity	associated_with	mechanism	0.90
immunosuppression	causes	phenotype	0.90
A1 reactive astrocytes	activates	cell_type	0.90
Microglial Synapse Engulfment	activates	process	0.90
Microglial Synapse Engulfment	mediates	process	0.90
classical complement cascade	activates	pathway	0.90
complement_cascade	participates_in	pathway	0.90
Human Atherosclerotic Plaques	associated_with	disease	0.90
synaptic dysfunction	causes	phenotype	0.90
Synapse Loss	associated_with	phenotype	0.90
Synapse Elimination	mediates	process	0.90
Synapse Loss	promotes	phenotype	0.90
ISCHEMIC STROKE	associated_with	entity	0.90
NEUROINFLAMMATION	mediates	entity	0.90
Human Atherosclerotic Plaques	involved_in	phenotype	0.90
Phagocytosis	activates	pathway	0.90
Complement	inhibits	pathway	0.90
Beta-Amyloid Oligomers	interacts_with	compound	0.88
Inflammatory Reactivity	inhibits	phenotype	0.88
SYNAPSE_ELIMINATION	regulates	phenotype	0.87
Classical Complement Cascade	activates	pathway	0.85
Inhibitory Synapse Elimination	involved_in	process	0.85

Incoming (456)

Source	Relation	Type	Str
COMPLEMENT	activates	gene	1.00
MICROGLIA	associated_with	gene	1.00
ALZHEIMER'S DISEASE	associated_with	disease	1.00
NPTX2	binds	protein	0.95
SPP1	upregulates	entity	0.90
h-58e4635a	targets_gene	hypothesis	0.90
h-89500d80	targets_gene	hypothesis	0.90
NEURODEGENERATION	associated_with	gene	0.90
TYROBP deficiency	inhibits	phenotype	0.90
β-Amyloid Oligomers	interacts_with	compound	0.85
TYROBP	regulates	protein	0.85
MICROGLIA	inhibits	gene	0.82
AMYLOID	associated_with	gene	0.82
CD2AP	correlates_with	protein	0.80
STAT6-MafB pathway	contributes_to	pathway	0.80
microglia	produces	cell_type	0.80
MICROGLIA	expresses	gene	0.80
OCULAR HYPERTENSION	upregulates	biological_process	0.80
DOR	binds	gene	0.80
h-58e4635a	targets	hypothesis	0.80
ABETA	upregulates	protein	0.80
MICROGLIA	secretes	cell_type	0.80
SDA-2026-04-01-gap-013	targets	analysis	0.80
COMPLEMENT	regulates	gene	0.80
COMPLEMENT	inhibits	gene	0.80
ALZHEIMER	activates	gene	0.80
Microglia	associated_with	cell_type	0.75
Astrocytes	associated_with	cell_type	0.75
MICROGLIA	activates	cell_type	0.74
ASTROCYTES	associated_with	gene	0.74
MICROGLIA	expressed_in	cell_type	0.72
NPTX2	interacts_with	protein	0.72
C1QA	activates	gene	0.70
periodontal infection	activates	disease	0.70
APOE	co_mentioned_with	gene	0.70
ocular hypertension	activates	disease	0.70
h-89500d80	targets	hypothesis	0.70
NEURODEGENERATIVE DISEASES	causes	gene	0.70
NEURODEGENERATION	regulates	gene	0.70
AMYLOID	activates	gene	0.70
retinal ischemia/reperfusion injury	activates	process	0.70
HMGB1	enhances	gene	0.70
APOE	interacts_with	protein	0.70
oxidized lipids	activates	process	0.70
ALZHEIMER	regulates	gene	0.70
NEURODEGENERATION	activates	gene	0.70
NEURODEGENERATIVE DISEASES	activates	gene	0.70
COMPLEMENT	interacts_with	gene	0.70
PDE4B	regulates	gene	0.70
COMPLEMENT	associated_with	gene	0.70

Targeting Hypotheses (13)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
C1QA/C1QB Subunit-Specific Inhibition to Block Aberrant PV I	0.747	neurodegeneration	Are interneuron oscillation deficits com
Complement C1QA Spatial Gradient in Cortical Layers	0.678	Alzheimer's Disease	SEA-AD Gene Expression Profiling — Allen
Complement C1QA Inhibition Synergizes with PV Interneuron Mo	0.659	neurodegeneration	What molecular mechanisms underlie the d
C1Q-Triggered NLRP3 Inflammasome Assembly in Plaque Macropha	0.640	neuroinflammation	What are the specific molecular mechanis
C1Q-Induced Foam Cell Formation via Scavenger Receptor Upreg	0.620	neuroinflammation	What are the specific molecular mechanis

C1Q-Mediated Defective Efferocytosis Driving Necrotic Core E	0.600	neuroinflammation	What are the specific molecular mechanis
TREM2-C1Q Competitive Binding to Prevent Complement-Mediated	0.591	neurodegeneration	Do β-amyloid plaques and neurofibrillary
NFκB/C1Q SASP Modulation for Synaptic Protection	0.534	neurodegeneration	View
C1Q-Angiogenic Axis Promoting Plaque Neovascularization	0.530	neuroinflammation	What are the specific molecular mechanis
Tripartite Synapse Cell Type-Nonautonomous Crosstalk: Coordi	0.510	neurodegeneration	Cell type vulnerability debate in Alzhei
NETosis Amplification by C1Q in Plaque Neutrophils	0.500	neuroinflammation	What are the specific molecular mechanis
C1Q-Glia Cross-Talk in Vascular Dementia Pathogenesis	0.470	neuroinflammation	What are the specific molecular mechanis
Alectinib Binds Mitochondrial C1q-like Proteins (C1QDC1) Rat	0.122	molecular biology	Does Alectinib truly bind C1q directly w

Mentioning Analyses (24)

Scientific analyses that reference this entity

Experiments (13)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Model	Status	Est. Cost
Bidirectional Mendelian randomization analysis of C1Q and ischemic str	exploratory	Ischemic stroke, Atheroscleros	0.900	Human genetic association data	proposed	N/A
Bidirectional Mendelian randomization analysis of C1Q and ischemic str	exploratory	Ischemic stroke (large artery	0.900	human genetic data	proposed	N/A
Single-cell RNA sequencing analysis of human atherosclerotic plaques	exploratory	Atherosclerosis	0.900	Human atherosclerotic plaque s	proposed	N/A
C1q neutralization experiment	validation	perioperative neurocognitive d	0.900	rats	proposed	N/A
scRNA-seq analysis of human atherosclerotic plaques	exploratory	Atherosclerosis	0.900	human atherosclerotic plaque s	proposed	N/A
Sevoflurane-induced neurotoxicity (SIN) model in rats	validation	perioperative neurocognitive d	0.900	rats	proposed	N/A
Machine learning-based identification of C1Q hub genes	exploratory	Atherosclerosis	0.900	Human bulk RNA sequencing data	proposed	N/A
LPS-induced mouse model of depression with synaptic loss analysis	validation	depression	0.900	LPS-treated mice	proposed	N/A
Gene expression validation in apoE-/- mice	validation	Atherosclerosis	0.850	apoE-/- mice	proposed	N/A
ox-LDL treatment of RAW264.7 macrophages	exploratory	Atherosclerosis	0.850	RAW264.7 macrophages	proposed	N/A
C1q neutralizing antibody intervention in depression model	validation	depression	0.850	LPS-treated mice with C1q anti	proposed	N/A
Validation of hub genes in ox-LDL treated RAW264.7 macrophages	exploratory	Atherosclerosis	0.800	RAW264.7 macrophages	proposed	N/A
Validation of hub genes in apoE-/- atherosclerotic mice	validation	Atherosclerosis	0.800	apoE-/- mice	proposed	N/A

Related Papers (12)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Perivascular cells induce microglial phagocytic states and synaptic engulfment v [PMID:36747024]	De Schepper S, Ge JZ, Sierksma A, Crowle	Nat Neurosci	2023	2
Synaptic pruning genes networks in Alzheimer's disease: correlations with neurop [PMID:40515808]	Sanfilippo C, Castrogiovanni P, Imbesi R	Geroscience	2026	0
Molecular Insights Into Canine Hepatocellular Carcinoma: A Cross-Species Transcr [PMID:41664952]	Arif M, Hasan MN, Nozaki N, Ide Y, Akiya	Mol Carcinog	2026	0
Synaptic pruning genes networks in Alzheimer's disease: correlations with neurop [PMID:40515808]	Sanfilippo C, Castrogiovanni P, Imbesi R	GeroScience	2026	0
The dopamine analogue CA140 alleviates AD pathology, neuroinflammation, and resc [PMID:39129007]	Chae S, Lee HJ, Lee HE, Kim J, Jeong YJ,	Journal of neuroinflammation	2024	0
Identification of crosstalk genes and immune characteristics between Alzheimer's [PMID:39188714]	An W, Zhou J, Qiu Z, Wang P, Han X, Chen	Frontiers in immunology	2024	0
[WALANT - Wide Awake Local Anaesthesia No Tourniquet: Complications in elective [PMID:35168268]	Wieschollek S, Forster S, Megerle K	Handchirurgie, Mikrochirurgie,	2022	0
Adaptive learning algorithms to optimize mobile applications for behavioral heal [PMID:33657217]	Figueroa CA, Aguilera A, Chakraborty B,	Journal of the American Medica	2021	0
Engineering complex communities by directed evolution. [PMID:33986540]	Chang CY, Vila JCC, Bender M, Li R, Mank	Nature ecology & evolution	2021	0
A Novel N-terminal Region to Chromodomain in CHD7 is Required for the Efficient [PMID:34161779]	Lee E, Kang C, Purhonen P, Hebert H, Bou	Journal of molecular biology	2021	0
Neurotoxic microglia promote TDP-43 proteinopathy in progranulin deficiency. [PMID:32866962]	Zhang J, Velmeshev D, Hashimoto K, Huang	Nature	2020	0
Progranulin Deficiency Promotes Circuit-Specific Synaptic Pruning by Microglia v [PMID:27114033]	Lui H, Zhang J, Makinson SR, Cahill MK,	Cell	2016	0

Debates (20)

Multi-agent debates referencing this entity

C1Q

Understanding Entity Pages

Summary

Wiki Pages (7)

C1QA Gene — Complement Component 1q A Chain

C1QB Protein — Complement Component 1 Q

C1QA Gene

C1Q Protein (Complement Component 1q)

C1QB — Complement Component 1Q Beta

C1QC Protein

C1QC

Pathway Diagram

Outgoing (1139)

Incoming (456)

Targeting Hypotheses (13)

Mentioning Analyses (24)

Do β-amyloid plaques and neurofibrillary tangles cause or result from cholinergi

Why does PRKN-mediated mitophagy, typically protective, cause harmful mitochondr

Do these mechanistic hypotheses from the SEA-AD Atlas bundle explain layer-speci

Do these mechanistic hypotheses explain layer-specific synaptic vulnerability in

Mechanistic validation of SEA-AD differential expression hypotheses: Complement

How does SPI1 transcriptionally regulate C1QA and C1QC expression in atheroscler

What are the specific molecular mechanisms by which C1Q components drive atheros

Epigenetic reprogramming in aging neurons

Tau propagation mechanisms and therapeutic interception points

Which cell types show the most significant expression changes for neurodegenerat

Gene expression changes in aging mouse brain predicting neurodegenerative vulner

Cell type vulnerability in Alzheimers Disease (SEA-AD transcriptomic data)

Synaptic pruning by microglia in neurodegeneration

Epigenetic clocks and biological aging in neurodegeneration

Mitochondrial transfer between astrocytes and neurons

RNA binding protein dysregulation across ALS FTD and AD

Synaptic pruning by microglia in early AD

Senolytic therapy for age-related neurodegeneration

Autophagy-lysosome pathway convergence across neurodegenerative diseases

Microglia-astrocyte crosstalk amplification loops in neurodegeneration

Astrocyte reactivity subtypes in neurodegeneration

4R-tau strain-specific spreading patterns in PSP vs CBD

Blood-brain barrier transport mechanisms for antibody therapeutics

Mechanistic role of APOE in neurodegeneration

Experiments (13)

Related Papers (12)

Debates (20)

What is the role of microglial synaptic pruning in Alzheimer's disease and other

While the study establishes C1QA and C1QC as diagnostic biomarkers and confirms

Mechanistic validation of SEA-AD differential expression hypotheses: Complement

Mechanistic validation of SEA-AD differential expression hypotheses: Complement

Do these mechanistic hypotheses explain layer-specific synaptic vulnerability in

Do these mechanistic hypotheses from the SEA-AD Atlas bundle explain layer-speci

The abstract explicitly questions whether AD's hallmark pathologies induce choli

The abstract reveals an unexpected contradiction where PRKN activation, normally

Investigate prion-like spreading of tau pathology through connected brain region

PSP and CBD both involve 4R-tau but produce distinct neuropathological patterns