concept

CORTEX

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CORTEX: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1928Connections

3Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

1Debates

Summary

CORTEX is a concept in neurodegeneration research. Key relationships include: co discussed, associated with, activates. Associated with ALS, ALZHEIMER, ALZHEIMER'S. Connected to 105 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	CORTEX
Key Genes/Proteins	ABCA1, ABCA7, ABI3, ACHE, ACSL4, ADAM10
Related Diseases	ACETYLCHOLINE, AGING, ALS, ALZHEIMER, ALZHEIMER'S

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Entorhinal Cortex

brain · 3091 words

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Pathway Diagram

graph TD
    CORTEX["CORTEX"]
    BDNF["BDNF"] -->|"expressed in"| CORTEX
    MEF2C["MEF2C"] -->|"expressed in"| CORTEX
    HCN1["HCN1"] -->|"expressed in"| CORTEX
    EPILEPSY["EPILEPSY"] -->|"expressed in"| CORTEX
    ASTROCYTES["ASTROCYTES"] -->|"expressed in"| CORTEX
    AGING["AGING"] -->|"expressed in"| CORTEX
    TET2["TET2"] -->|"expressed in"| CORTEX
    DNA["DNA"] -->|"expressed in"| CORTEX
    GENES["GENES"] -->|"expressed in"| CORTEX
    CANCER["CANCER"] -->|"expressed in"| CORTEX

Outgoing (736)

Target	Relation	Type	Str
EPILEPSY	interacts_with	disease	0.95
STRIATUM	expressed_in	brain_region	0.95
HIPPOCAMPUS	inhibits	brain_region	0.95
INTERNEURONS	expressed_in	cell_type	0.95
HIPPOCAMPUS	regulates	brain_region	0.95
STEM CELLS	activates	cell_type	0.95
NEURON	activates	cell_type	0.95
NEURON	interacts_with	cell_type	0.95
HIPPOCAMPUS	activates	brain_region	0.95
PARVALBUMIN INTERNEURONS	expressed_in	entity	0.85
NEURON	associated_with	cell_type	0.80
CA1	causes	brain_region	0.70
ALS	treats	disease	0.70
SYNAPTIC LOSS	regulates	phenotype	0.70
SYNAPTIC LOSS	causes	phenotype	0.70
ASTROCYTE	causes	cell_type	0.70
HIPPOCAMPUS	accumulates_in	brain_region	0.65
SPINAL CORD	expressed_in	brain_region	0.65
CLU	regulates	gene	0.65
PREFRONTAL CORTEX	targets	brain_region	0.65
ENTORHINAL	associated_with	brain_region	0.65
PREFRONTAL CORTEX	mediates	brain_region	0.65
MEMORY LOSS	treats	phenotype	0.65
GRN	treats	gene	0.65
PREFRONTAL CORTEX	causes	brain_region	0.65
DENTATE GYRUS	activates	brain_region	0.65
WHITE MATTER	reduces	brain_region	0.65
OLIGODENDROCYTE	phosphorylates	cell_type	0.65
EPILEPSY	regulates	disease	0.65
WHITE MATTER	phosphorylates	brain_region	0.65
PROGRESSIVE SUPRANUCLEAR PALSY	regulates	disease	0.65
FUS	transports	gene	0.65
DENTATE GYRUS	regulates	brain_region	0.65
PREFRONTAL CORTEX	biomarker_for	brain_region	0.65
ENTORHINAL CORTEX	treats	brain_region	0.65
MAPK	regulates	gene	0.65
TAU	expressed_in	gene	0.65
OLIGODENDROCYTES	phosphorylates	cell_type	0.65
ALZHEIMER'S DISEASE	interacts_with	disease	0.65
AMYLOID-BETA	treats	protein	0.65
TEMPORAL LOBE	activates	brain_region	0.65
INTERNEURONS	targets	cell_type	0.65
FRONTOTEMPORAL DEMENTIA	activates	disease	0.65
THALAMUS	expressed_in	brain_region	0.65
SPINAL CORD	accumulates_in	brain_region	0.65
IPSC	activates	cell_type	0.65
PINK1	treats	gene	0.65
GLUTAMATERGIC	activates	cell_type	0.65
PI3K	causes	gene	0.65
INTERNEURON	targets	cell_type	0.65

Incoming (1192)

Source	Relation	Type	Str
ALZHEIMER'S DISEASE	associated_with	disease	1.00
AMYLOID	associated_with	protein	1.00
NF-KB	associated_with	protein	1.00
PARKINSON'S DISEASE	associated_with	disease	1.00
TAU	associated_with	protein	1.00
TNF	associated_with	gene	1.00
MICROGLIA	associated_with	cell_type	1.00
ASTROCYTES	associated_with	cell_type	1.00
APP	associated_with	gene	1.00
TARDBP	associated_with	gene	1.00
ALS	associated_with	disease	0.98
epilepsy	affects	disease	0.90
neurodegeneration	affects	disease	0.90
GFAP	expressed_in	gene	0.90
Alzheimer's disease	affects	disease	0.90
unfolded protein response	active_in	pathway	0.90
traumatic brain injury	affects	disease	0.90
frontotemporal dementia	affects	disease	0.90
APP	expressed_in	gene	0.90
depression	affects	disease	0.90
aging	affects	disease	0.90
schizophrenia	affects	disease	0.90
neuroinflammation	affects	disease	0.90
SST	expressed_in	gene	0.90
DNA	expressed_in	gene	0.90
BDNF	expressed_in	gene	0.90
ALS	affects	disease	0.90
ALS	expressed_in	gene	0.90
HCN1	expressed_in	entity	0.90
RNA	expressed_in	gene	0.90
BDNF	associated_with	gene	0.90
DNA METHYLATION	expressed_in	entity	0.85
AMPK	associated_with	gene	0.82
ASTROCYTES	expressed_in	cell_type	0.82
RELN	expressed_in	entity	0.80
AQP4	expressed_in	gene	0.80
IL-6	associated_with	gene	0.80
CEREBELLUM	expressed_in	brain_region	0.80
CREB	expressed_in	gene	0.80
AMYGDALA	expressed_in	brain_region	0.80
MTOR	associated_with	gene	0.80
HDAC3	expressed_in	gene	0.80
AMYGDALA	regulates	brain_region	0.80
autism	affects	disease	0.80
AMPK	expressed_in	gene	0.80
PI3K-AKT-mTOR signaling	active_in	pathway	0.80
APOE	expressed_in	gene	0.80
anxiety	affects	disease	0.80
TDP43	expressed_in	entity	0.80
TNF	expressed_in	gene	0.80

Targeting Hypotheses (3)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Closed-loop tACS targeting entorhinal cortex layer II SST in	0.784	Alzheimer's disease	Circuit-level neural dynamics in neurode
Rab27A/B-mediated exosomal tau secretion from microglia driv	0.690	neurodegeneration	Which tau propagation mechanism predomin
APOE4 Induces Region-Specific Microglial Senescence Driving	0.600	neuroinflammation	How do regional, age, and sex-dependent

Mentioning Analyses (1)

Scientific analyses that reference this entity

Allen Mouse Brain Aging Atlas: cross-age gene expression analysis

neurodegeneration | 2026-04-23 | 8 hypotheses Top: 0.680

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

How does gene expression change across age groups (young/middle/old) in hippocam

active · Rounds: 4 · Score: 1.00 · 2026-04-24

Related Research

Hypotheses and analyses mentioning CORTEX in their description or question text

No additional research found