gene

TSC1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TSC1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

213Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

1Debates

Summary

TSC1 is a gene implicated in neurodegeneration research. Key relationships include: regulates, interacts with, expressed in. Associated with Aging, Als, Atherosclerosis. Connected to 124 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	TSC1
Full Name	Tuberous Sclerosis Complex 1
Function	It contains several functional domains including a hamartin elbow domain (HED), a transmembrane region, and a conserved tuberous sclerosis complex domain (TSC-TBD)[1].
Primary Expression	neurons and plays important roles in synaptic plasticity, dendritic spine morphology, and neuronal connectivity
Subcellular Localization	the cytoplasm and plasma membrane. It contains several functional domains including a hamartin elbow domain (HED), a tra
Molecular Weight	130 kDa
Amino Acids	164 aa
Pathways	mTOR Signaling, mTOR, mtor
Ensembl ID	ENSG00000115159
GeneCards	TSC1
Human Protein Atlas	TSC1
Cortical tubers	Benign hamartomas in the cerebral cortex
Facial angiofibromas	Adenoma sebaceum
Hypomelanotic macules	Ash-leaf spots
Shagreen patches	Connective tissue nevi
Associated Diseases	Aging, Als, Cardiovascular, epilepsy, Ms, Tuberous sclerosis complex
Known Drugs/Compounds	rapamycin
Interactions	Akt, AKT, AKT1, AKT3, AMPK, AND
KG Connections	213 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

TSC1 — Tuberous Sclerosis Complex 1

gene · 834 words

→

TSC1 Protein — Hamartin

protein · 1180 words

→

Pathway Diagram

graph TD
    TSC1["TSC1"]
    TSC2["TSC2"]
    TSC1 -->|"interacts with"| TSC2
    mTOR_signaling(["mTOR signaling"])
    TSC1 -->|"regulates"| mTOR_signaling
    mTOR["mTOR"]
    TSC1 -->|"inhibits"| mTOR
    Leukemia{"Leukemia"}
    TSC1 -->|"regulates"| Leukemia
    Als{"Als"}
    TSC1 -->|"regulates"| Als
    TSC1 -->|"interacts with"| Als
    Ms{"Ms"}
    TSC1 -->|"interacts with"| Ms
    Autism{"Autism"}
    TSC1 -->|"regulates"| Autism
    Tumor{"Tumor"}
    TSC1 -->|"regulates"| Tumor
    TSC1 -->|"therapeutic target"| Ms
    Carcinoma{"Carcinoma"}
    TSC1 -->|"interacts with"| Carcinoma
    TSC1 -->|"inhibits"| Als
    TSC2 -->|"inhibits"| TSC1
    ATF4["ATF4"]
    ATF4 -->|"regulates"| TSC1
    TSC2 -->|"regulates"| TSC1
    PTEN["PTEN"]
    PTEN -->|"regulates"| TSC1
    PI3K["PI3K"]
    PI3K -->|"regulates"| TSC1
    TSC2 -->|"interacts with"| TSC1
    TFEB["TFEB"]
    TFEB -->|"regulates"| TSC1
    TFEB -->|"therapeutic target"| TSC1
    AGING["AGING"]
    AGING -->|"associated with"| TSC1
    style TSC1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (135)

Target	Relation	Type	Str
Tuberous sclerosis complex	causes	disease	0.95
TSC2	interacts_with	protein	0.90
Frontotemporal dementia	risk_factor_for	disease	0.85
Als	interacts_with	disease	0.85
mTOR signaling	regulates	pathway	0.80
Mtor	interacts_with	pathway	0.80
Autism	interacts_with	disease	0.75
MTOR	interacts_with	gene	0.70
MTOR	regulates	gene	0.70
MTOR	inhibits	gene	0.70
MTOR	activates	gene	0.70
Mtor	regulates	pathway	0.70
mTOR	inhibits	protein	0.70
Mtor	activates	pathway	0.70
Als	causes	disease	0.65
Tumor	interacts_with	disease	0.65
Cardiac	interacts_with	disease	0.65
Als	activates	disease	0.65
Inflammation	activates	disease	0.65
Tumor	expressed_in	disease	0.65
Cancer	expressed_in	disease	0.65
Als	therapeutic_target	disease	0.65
Als	expressed_in	disease	0.65
Gastric Cancer	expressed_in	disease	0.65
Cancer	regulates	disease	0.65
Atherosclerosis	regulates	disease	0.65
Epilepsy	interacts_with	disease	0.65
Carcinoma	interacts_with	disease	0.65
Tumor	inhibits	disease	0.65
Cancer	activates	disease	0.65
Carcinoma	activates	disease	0.65
Als	inhibits	disease	0.65
Ms	inhibits	disease	0.65
Ms	causes	disease	0.65
Ms	interacts_with	disease	0.65
Epilepsy	therapeutic_target	disease	0.65
Epilepsy	activates	disease	0.65
Als	associated_with	disease	0.65
Aging	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Tumor	regulates	disease	0.65
Cardiovascular	associated_with	disease	0.65
Ms	therapeutic_target	disease	0.65
Autism	regulates	disease	0.65
Leukemia	regulates	disease	0.65
Als	regulates	disease	0.65
EPILEPSY	therapeutic_target	gene	0.60
MTORC1	encodes	gene	0.60
KMT2A	expressed_in	gene	0.60
MAPK	inhibits	gene	0.60

Incoming (78)

Source	Relation	Type	Str
TSC2	inhibits	gene	0.80
TSC2	interacts_with	gene	0.70
GENES	inhibits	gene	0.70
EPILEPSY	activates	gene	0.60
RHEB	activates	gene	0.60
AKT1	activates	gene	0.60
RPS6KB1	activates	gene	0.60
PDPK1	activates	gene	0.60
EIF4EBP1	activates	gene	0.60
ATG5	causes	gene	0.60
BECLIN1	causes	gene	0.60
LC3	causes	gene	0.60
PI3K	inhibits	gene	0.60
PI3K	expressed_in	gene	0.60
PIK3CB	expressed_in	gene	0.60
DDB1	regulates	gene	0.60
PTEN	activates	gene	0.60
RPS6	activates	gene	0.60
ERK	inhibits	gene	0.60
AMPK	inhibits	gene	0.60
P53	inhibits	gene	0.60
CANCER	regulates	gene	0.60
INFLAMMATION	activates	gene	0.60
AND	inhibits	gene	0.60
MTORC1	inhibits	gene	0.60
GENES	activates	gene	0.60
AND	therapeutic_target	gene	0.60
AGING	associated_with	gene	0.60
ATF4	regulates	gene	0.60
APOPTOSIS	regulates	gene	0.60
rapamycin	targets	drug	0.60
PI3K	regulates	gene	0.60
AKT	interacts_with	gene	0.60
NLGN1	encodes	gene	0.60
GENES	causes	gene	0.60
EPILEPSY	interacts_with	gene	0.60
MTORC1	activates	gene	0.60
GENES	interacts_with	gene	0.60
TSC2	activates	gene	0.60
TSC2	regulates	gene	0.60
PTEN	regulates	gene	0.60
MTOR	activates	gene	0.60
AKT3	activates	gene	0.60
NPRL2	activates	gene	0.60
PIK3CA	activates	gene	0.60
DEPDC5	activates	gene	0.60
NPRL3	activates	gene	0.60
NLGN1	activates	gene	0.60
CDKN2A	expressed_in	gene	0.60
MAP2K2	expressed_in	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

TREM2 agonism vs antagonism in DAM microglia

neurodegeneration | 2026-04-02 | 7 hypotheses Top: 0.741

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

The disease-associated microglia (DAM) phenotype involves TREM2 upregulation, bu

closed · Rounds: 4 · Score: 0.89 · 2026-04-02

Related Research

Hypotheses and analyses mentioning TSC1 in their description or question text

No additional research found