concept

NEURONAL APOPTOSIS

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NEURONAL APOPTOSIS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

72Connections

1Hypotheses

2Analyses

1Outgoing

50Incoming

0Experiments

2Debates

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💡 Concept Info

Name	NEURONAL APOPTOSIS

Pathway Diagram

graph TD
    NEURONAL_APOPTOSIS["NEURONAL APOPTOSIS"]
    ASK1["ASK1"] -->|"regulates"| NEURONAL_APOPTOSIS
    Yiqi_Tongluo_Granule["Yiqi Tongluo Granule"] -->|"inhibits"| NEURONAL_APOPTOSIS
    Cordycepin["Cordycepin"] -->|"inhibits"| NEURONAL_APOPTOSIS
    Caspase_3["Caspase-3"] -->|"promotes"| NEURONAL_APOPTOSIS
    DLK_Inhibition["DLK Inhibition"] -->|"inhibits"| NEURONAL_APOPTOSIS
    Bergenin["Bergenin"] -->|"inhibits"| NEURONAL_APOPTOSIS
    C3_C3aR_Pathway["C3/C3aR Pathway"] -->|"activates"| NEURONAL_APOPTOSIS

Outgoing (1)

Target	Relation	Type	Str
Cognitive Deficits	causes	phenotype	0.85

Incoming (71)

Source	Relation	Type	Str
ASK1	regulates	protein	0.95
ASK1	activates	protein	0.95
BDNF	protects_against	protein	0.95
Bergenin	inhibits	compound	0.90
mitochondrial dysfunction	promotes	phenotype	0.90
Ceramide	promotes	compound	0.90
Caspase-3	promotes	protein	0.90
Cordycepin	inhibits	compound	0.90
35002518	causes	paper	0.90
DLK Inhibition	inhibits	mechanism	0.90
ER Stress	contributes_to	process	0.90
TP53	activates	protein	0.90
toxic N-terminal fragments	causes	biomarker	0.90
Yiqi Tongluo Granule	inhibits	drug	0.90
Aucubin	suppresses	compound	0.90
TAZ	suppresses	gene	0.90
ZFP36	inhibits	gene	0.90
PGAM5	promotes	protein	0.90
Unfolded Protein Response	mediates	pathway	0.90
XYS	inhibits	compound	0.90
Brain Cholesterol Accumulation	promotes	phenotype	0.90
ACTG1	promotes	protein	0.90
C3/C3aR Pathway	activates	pathway	0.88
Bergenin	protects_against	compound	0.88
TLR2	promotes	gene	0.88
mitochondrial dysfunction	drives	phenotype	0.88
Tong-Qiao-Huo-Xue Decoction	inhibits	drug	0.87
ACTG1	promotes	protein	0.85
Chronic Demyelination	causes	disease	0.85
Complement C3/C3Ar Pathway	mediates	pathway	0.85
PI3K-Akt Signaling Pathway	modulates	pathway	0.85
ceramide	promotes	compound	0.85
L-glutamate	drives	compound	0.85
Ceramide	causes	compound	0.85
TLR2	promotes	gene	0.85
Aucubin	suppresses	compound	0.85
AMYLOID BETA	causes	protein	0.85
Myriocin	regulates	drug	0.85
mitochondrial transfer	protects_against	process	0.85
Honokiol	inhibits	compound	0.80
TUFM	promotes	gene	0.80
WDR45	causes	gene	0.80
ERK	inhibits	protein	0.80
BDNF	inhibits	gene	0.80
CLU	modulates	protein	0.80
Steroid Hormones	regulates	compound	0.80
BDNF	inhibits	gene	0.80
Pyroptosis	associated_with	process	0.80
PROBDNF	promotes	protein	0.80
Steroid Hormones	inhibits	compound	0.72

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Colonic Th17/IL-17A Axis → Peripheral Immune Recruitment to	0.640	neurodegeneration	What are the mechanisms by which gut mic

Mentioning Analyses (2)

Scientific analyses that reference this entity

What molecular mechanisms underlie the dose-dependent protective effects of the

neurodegeneration | 2026-04-13 | 2 hypotheses Top: 0.659

How does chronic cGAS/STING activation downstream of TDP-43 contribute to progre

neuroinflammation | 2026-04-07 | 8 hypotheses Top: 0.771

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (2)

Multi-agent debates referencing this entity

The study identifies cGAS/STING activation as a consequence of TDP-43-mediated m

closed · Rounds: 4 · Score: 0.73 · 2026-04-21

The study shows homozygous R136S fully rescues APOE4-driven pathology while hete

closed · Rounds: 4 · Score: 0.81 · 2026-04-14

Related Research

Hypotheses and analyses mentioning NEURONAL APOPTOSIS in their description or question text

No additional research found