gene

CD36

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CD36: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

570Connections

1Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

CD36 is a gene implicated in neurodegeneration research. Key relationships include: activates, inhibits, regulates. Associated with ALS, Als, Alzheimer. Connected to 248 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	CD36
Aliases	Comprehensive review of CD36 scavenger receptor
Chromosome	7q21.11
Protein Type	Gene
Function	is a multifunctional class B scavenger receptor encoded by the CD36 gene located on chromosome 7q21.
Molecular Weight	88 kDa
Amino Acids	472 aa
Exons	15
Pathways	Amyloid, Cholesterol, Epigenetic, Ferroptosis, Lipid Metabolism
GeneCards	CD36
Human Protein Atlas	CD36
Associated Diseases	ALS, Alzheimer, Atherosclerosis, Cancer, Inflammation, Myocardial Infarction
Interactions	ABCA1, ABCG1, AGING, AKT, ALZHEIMER, ALZHEIMER'S DISEASE
KG Connections	570 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

cd36

gene · 2666 words

→

CD36 Protein (Cluster of Differentiation 36)

protein · 914 words

→

Pathway Diagram

flowchart TD
    AmyloidB["Amyloid beta
Plaques"] -->|"activates"| CD36["CD36
Scavenger Receptor"]
    CD36 -->|"activates"| PINK1["PINK1
Mitochondrial Kinase"]
    CD36 -->|"promotes"| Pericytes["Pericytes
BBB Support"]
    CD36 -->|"activates"| Inflammation["Systemic
Inflammation"]
    CD36 -->|"activates"| Neuroinflammation["Neuroinflammation
CNS Immune Response"]
    CD36 -->|"regulates"| MS["Multiple
Sclerosis"]
    CD36 -->|"interacts_with"| Alzheimer["Alzheimer's
Disease"]
    CD36 -->|"inhibits"| ALS_Protection["ALS
Neuroprotection"]
    CD36 -->|"associated_with"| Stroke["Ischemic
Stroke"]
    
    Neuroinflammation -->|"contributes_to"| Alzheimer
    Neuroinflammation -->|"worsens"| MS
    Inflammation -->|"promotes"| Neuroinflammation
    PINK1 -->|"maintains"| MitoFunction["Mitochondrial
Function"]
    Pericytes -->|"maintains"| BBB["Blood-Brain
Barrier Integrity"]
    
    MitoFunction -->|"protects_against"| Neurodegeneration["Neuronal
Death"]
    BBB -->|"prevents"| Neuroinflammation
    
    style CD36 fill:#006494
    style PINK1 fill:#4a1a6b
    style Pericytes fill:#1b5e20
    style BBB fill:#1b5e20
    style MitoFunction fill:#1b5e20
    style ALS_Protection fill:#1b5e20
    style AmyloidB fill:#ef5350
    style Inflammation fill:#ef5350
    style Neuroinflammation fill:#ef5350
    style Alzheimer fill:#5d4400
    style MS fill:#5d4400
    style Stroke fill:#5d4400
    style Neurodegeneration fill:#5d4400

Outgoing (409)

Target	Relation	Type	Str
LIPID METABOLISM	involved_in	entity	0.85
Lipid Metabolism	associated_with	process	0.85
autophagy flux	inhibits	process	0.85
Inflammation	activates	disease	0.85
Phagocytosis	involved_in	process	0.85
Ovarian Cancer	therapeutic_target	disease	0.80
Ovarian Cancer	biomarker_for	disease	0.80
sepsis-induced liver injury	promotes	disease	0.80
Tumor Immune Cell Activity	regulates	process	0.80
Tumor	inhibits	disease	0.75
LC3	modulates	protein	0.75
Neuroinflammation	activates	disease	0.75
Inflammation	regulates	disease	0.75
PINK1	activates	protein	0.70
ubiquitin-proteasome	participates_in	pathway	0.70
PINK1	interacts_with	protein	0.70
AKT	inhibits	gene	0.70
blood-brain barrier	participates_in	pathway	0.70
INFLAMMATION	activates	gene	0.70
pericyte	regulates	cell_type	0.70
pericyte	activates	cell_type	0.70
microglia	expressed_in	cell_type	0.70
NEUROINFLAMMATION	activates	gene	0.70
Pi3K/Akt	inhibits	pathway	0.70
ATP	inhibits	gene	0.70
Phagocytosis	regulates	pathway	0.70
Lipid Metabolism	inhibits	pathway	0.70
Autophagy	inhibits	pathway	0.70
Lipid Metabolism	activates	pathway	0.70
ASTROCYTES	inhibits	gene	0.70
Tumor	expressed_in	disease	0.65
Leukemia	inhibits	disease	0.65
Senescence	inhibits	disease	0.65
Alzheimer	inhibits	disease	0.65
Cancer	activates	disease	0.65
Alzheimer	activates	disease	0.65
Carcinoma	inhibits	disease	0.65
Cancer	associated_with	disease	0.65
Inflammation	inhibits	disease	0.65
Myocardial Infarction	implicated_in	disease	0.65
Fibrosis	activates	disease	0.65
Atherosclerosis	inhibits	disease	0.65
Carcinoma	activates	disease	0.65
Cirrhosis	activates	disease	0.65
Spinal Cord Injury	associated_with	disease	0.65
Fatty Liver	inhibits	disease	0.65
Stroke	associated_with	disease	0.65
Neuroinflammation	regulates	disease	0.65
Traumatic Brain Injury	regulates	disease	0.65
Insulin Resistance	inhibits	disease	0.65

Incoming (161)

Source	Relation	Type	Str
TFEB	regulates	gene	0.85
PPARΑ	upregulates	gene	0.80
PPARΑ	regulates	gene	0.80
AMYLOID	associated_with	disease	0.80
SPP1	upregulates	gene	0.75
PI3K	inhibits	gene	0.70
AMPK	inhibits	gene	0.70
Amyloid β	activates	protein	0.70
UBQLN1	regulates	gene	0.60
PLIN2	activates	gene	0.60
NR1H3	activates	gene	0.60
ANG	activates	gene	0.60
ADRA2A	associated_with	gene	0.60
ABCA1	activates	gene	0.60
CYTOKINES	biomarker_for	gene	0.60
FERROPTOSIS	regulates	gene	0.60
ROS	regulates	gene	0.60
APP/PS1	activates	gene	0.60
OXIDATIVE STRESS	inhibits	gene	0.60
ALZHEIMER	activates	gene	0.60
GASTRODIN	activates	gene	0.60
AUTOPHAGY	activates	gene	0.60
OXIDATIVE STRESS	activates	gene	0.60
RNA	activates	gene	0.60
LC3B	activates	gene	0.60
PARKINSON	regulates	gene	0.60
OXIDATIVE STRESS	regulates	gene	0.60
SREBP2	regulates	gene	0.60
NEURODEGENERATION	causes	gene	0.60
NEUROINFLAMMATION	causes	gene	0.60
INFLAMMATION	causes	gene	0.60
CYTOKINES	causes	gene	0.60
ALZHEIMER	causes	gene	0.60
ALZHEIMER'S DISEASE	causes	gene	0.60
AMYLOID	causes	gene	0.60
BRAIN INJURY	regulates	gene	0.60
MAPK	regulates	gene	0.60
RAGE	associated_with	gene	0.60
FAS	expressed_in	gene	0.60
SIRT6	activates	gene	0.60
HNRNPA2B1	regulates	gene	0.60
IDE	activates	gene	0.60
P38	regulates	gene	0.60
CD14	associated_with	gene	0.60
CD163	activates	gene	0.60
HK2	inhibits	gene	0.60
MYC	inhibits	gene	0.60
ARG1	inhibits	gene	0.60
ABCG1	inhibits	gene	0.60
TNF	inhibits	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
CD36 Acts as Primary Aβ Oligomer Sensor on Perivascular Macr	0.535	neurodegeneration	How do perivascular cells specifically r

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CD36 in their description or question text

No additional research found