PHAGOCYTOSIS
Entity Detail — Knowledge Graph Node
Understanding Entity Pages
This page aggregates everything SciDEX knows about PHAGOCYTOSIS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Summary
PHAGOCYTOSIS is a gene implicated in neurodegeneration research. Key relationships include: activates, associated with, interacts with. Associated with ALS, ALZHEIMER, ALZHEIMER'S. Connected to 963 entities in the SciDEX knowledge graph.
AI-generated illustration · click image to enlarge
Regenerate portrait ↻| Gene Symbol | PHAGOCYTOSIS |
| Aliases | phagocytosis |
| Associated Diseases | Aging, Als, Alzheimer, Alzheimer Disease, ALZHEIMER'S DISEASE |
| Known Drugs/Compounds | MELATONIN, RAPAMYCIN |
| Interactions | ACOX1, Actin, Adiponectin, AGING, AIM2, AKT |
| KG Connections | 1895 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Pathway Diagram
graph TD
PHAGOCYTOSIS["PHAGOCYTOSIS"] -->|"activates"| Dementia["Dementia"]
PHAGOCYTOSIS["PHAGOCYTOSIS"] -->|"activates"| Inflammation["Inflammation"]
PHAGOCYTOSIS["PHAGOCYTOSIS"] -->|"activates"| Alzheimer["Alzheimer"]
PHAGOCYTOSIS["PHAGOCYTOSIS"] -->|"activates"| Als["Als"]
PHAGOCYTOSIS["PHAGOCYTOSIS"] -->|"activates"| Neuroinflammation["Neuroinflammation"]
PHAGOCYTOSIS["PHAGOCYTOSIS"] -->|"activates"| Ms["Ms"]
MICROGLIA["MICROGLIA"] -->|"associated"| PHAGOCYTOSIS["PHAGOCYTOSIS"]
MSR1["MSR1"] -->|"regulates"| PHAGOCYTOSIS["PHAGOCYTOSIS"]
BAG3["BAG3"] -->|"activates"| PHAGOCYTOSIS["PHAGOCYTOSIS"]
C1Q["C1Q"] -->|"activates"| PHAGOCYTOSIS["PHAGOCYTOSIS"]
style PHAGOCYTOSIS fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0Outgoing (1237)
| Target | Relation | Type | Str |
|---|---|---|---|
| Immune Response | activates | pathway | 1.00 |
| Tumor | activates | disease | 1.00 |
| Autophagy | associated_with | pathway | 1.00 |
| AUTOPHAGY | associated_with | gene | 1.00 |
| Phagocytosis | activates | pathway | 1.00 |
| MICROGLIA | activates | gene | 1.00 |
| Inflammation | activates | disease | 1.00 |
| Als | activates | disease | 1.00 |
| Inflammation | regulates | disease | 1.00 |
| Cancer | activates | disease | 1.00 |
| Neurodegeneration | activates | disease | 1.00 |
| Neuroinflammation | activates | disease | 1.00 |
| Phagocytosis | regulates | pathway | 1.00 |
| NEUROINFLAMMATION | activates | gene | 1.00 |
| Neurodegeneration | associated_with | disease | 1.00 |
| Als | regulates | disease | 1.00 |
| Als | associated_with | disease | 1.00 |
| Phagocytosis | associated_with | pathway | 1.00 |
| Inflammation | associated_with | disease | 1.00 |
| MICROGLIA | associated_with | gene | 1.00 |
| Complement | activates | pathway | 1.00 |
| MICROGLIA | regulates | gene | 1.00 |
| Phagocytosis | inhibits | pathway | 1.00 |
| Alzheimer | regulates | disease | 0.95 |
| Alzheimer | associated_with | disease | 0.95 |
| Alzheimer | therapeutic_target | disease | 0.95 |
| Infection | activates | disease | 0.95 |
| Alzheimer | activates | disease | 0.95 |
| Stroke | activates | disease | 0.95 |
| Aging | regulates | disease | 0.95 |
| alzheimer_disease | modulates | disease | 0.90 |
| AKT | activates | gene | 0.90 |
| Nf-Κb | activates | pathway | 0.90 |
| Phagocytosis | expressed_in | pathway | 0.90 |
| Alzheimer | inhibits | disease | 0.85 |
| Aging | activates | disease | 0.85 |
| Neuroinflammation | implicated_in | disease | 0.85 |
| Als | therapeutic_target | disease | 0.85 |
| alzheimers | contributes_to | disease | 0.85 |
| Als | interacts_with | disease | 0.85 |
| Alzheimer's Disease Progression | involved_in | phenotype | 0.85 |
| alzheimer_disease | involved_in | disease | 0.80 |
| protein aggregation | modulates | mechanism | 0.80 |
| microglial_activation | involved_in | mechanism | 0.80 |
| STROKE | activates | gene | 0.80 |
| Apoptosis | activates | pathway | 0.80 |
| Inflammasome | activates | pathway | 0.80 |
| Immunotherapy | activates | pathway | 0.80 |
| GENES | activates | gene | 0.80 |
| Glycolysis | activates | pathway | 0.80 |
Incoming (1923)
| Source | Relation | Type | Str |
|---|---|---|---|
| PHAGOCYTOSIS | regulates | gene | 1.00 |
| Als | regulates | disease | 1.00 |
| Inflammation | regulates | disease | 1.00 |
| C1Q | activates | protein | 1.00 |
| Als | associated_with | disease | 1.00 |
| INFLAMMATION | regulates | gene | 1.00 |
| PHAGOCYTOSIS | associated_with | gene | 1.00 |
| MICROGLIA | activates | gene | 1.00 |
| Inflammation | associated_with | disease | 1.00 |
| Neurodegeneration | activates | disease | 1.00 |
| C1Q | activates | protein | 1.00 |
| INFLAMMATION | activates | gene | 1.00 |
| INFLAMMATION | activates | gene | 1.00 |
| Tumor | activates | disease | 1.00 |
| PHAGOCYTOSIS | activates | gene | 1.00 |
| LC3 | associated_with | gene | 1.00 |
| CYTOKINES | activates | gene | 1.00 |
| NEUROINFLAMMATION | activates | gene | 1.00 |
| Cancer | activates | disease | 1.00 |
| Neuroinflammation | activates | disease | 1.00 |
| AUTOPHAGY | associated_with | gene | 1.00 |
| Inflammation | activates | disease | 1.00 |
| Als | activates | disease | 1.00 |
| CANCER | activates | gene | 1.00 |
| LC3 | associated_with | gene | 1.00 |
| Alzheimer | activates | disease | 1.00 |
| INFLAMMATION | regulates | gene | 1.00 |
| NEURODEGENERATION | activates | gene | 1.00 |
| ALZHEIMER | activates | gene | 1.00 |
| TREM2 | activates | gene | 1.00 |
| LC3 | activates | gene | 1.00 |
| MICROGLIA | associated_with | gene | 1.00 |
| INFLAMMATION | associated_with | gene | 1.00 |
| INFLAMMATION | associated_with | gene | 1.00 |
| MICROGLIA | regulates | gene | 1.00 |
| Neurodegeneration | associated_with | disease | 1.00 |
| AKT | activates | gene | 1.00 |
| NEURODEGENERATION | associated_with | gene | 1.00 |
| TREM2 | activates | gene | 1.00 |
| PHAGOCYTOSIS | inhibits | gene | 1.00 |
| COMPLEMENT | activates | gene | 1.00 |
| LC3 | activates | gene | 1.00 |
| NEURODEGENERATION | activates | gene | 1.00 |
| CANCER | activates | gene | 1.00 |
| SPP1 | regulates | entity | 0.95 |
| Microglia | mediates | cell_type | 0.95 |
| Macrophages | involved_in | cell_type | 0.95 |
| microglial cells | involved_in | cell_type | 0.95 |
| Gastrodin | promotes | drug | 0.95 |
| microglia | associated_with | cell_type | 0.95 |
Targeting Hypotheses (16)
Hypotheses where this entity is a therapeutic target
Mentioning Analyses (2)
Scientific analyses that reference this entity
Does the cancer-cystatin-C-TREM2 pathway protect against tau pathology and other
neurodegeneration | 2026-04-25 | 8 hypotheses Top: 0.640
How do synthetic EVs achieve brain-specific targeting while avoiding reticuloend
drug delivery | 2026-04-15 | 0 hypotheses
Experiments (1)
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| E2F coordination of G2/M transcriptional program | exploratory | 0.750 | 0.00 | endocycling mammalian cells | proposed | N/A |
Related Papers (18)
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| The gain-of-function TREM2-T96K mutation increases risk for Alzheimer's disease [PMID:41109213] | Pilat DJ, Le H, Prokopenko D, Lin CJ, Ei | Neuron | 2026 | 0 |
| Role of TREM2 in neuroinflammation. [PMID:41213496] | Abdulkhaliq AA, Alasiri G, Almoghrabi Y, | Exp Neurol | 2026 | 0 |
| Synergistic potential of TREM2 agonists and exercise training in Alzheimer's dis [PMID:41494649] | Zhang J, St Pierre Schneider B, Muguerza | Am J Physiol Endocrinol Metab | 2026 | 0 |
| Obesity-induced pyroptotic adipocyte death leads to TREM2-dependent macrophage d [PMID:41509917] | Choi C, Lee J, Park G, Namgoong S, Lee Y | iScience | 2026 | 0 |
| Armored macrophage-targeted CAR-T cells reset and reprogram the tumor microenvir [PMID:41576929] | Mateus-Tique J, Lakshmi A, Singh B, Iyer | Cancer Cell | 2026 | 0 |
| Peripheral cancer attenuates amyloid pathology in Alzheimer's disease via cystat [PMID:41576952] | Li X, Tang X, Zeng J, Duan L, Hou Z et a | Cell | 2026 | 0 |
| TREM2 expression level is critical for microglial state, metabolic capacity and [PMID:41580393] | Feiten AF, Dahm K, Schlepckow K, van Len | Nat Commun | 2026 | 0 |
| Large-scale single-cell analysis and in silico perturbation reveal dynamic evolu [PMID:41617928] | Xia P, Shuang S, Fu D, Liu L, Yang D et | NPJ Precis Oncol | 2026 | 0 |
| Dissecting genetic and immune drivers of heterogeneous responses to neoadjuvant [PMID:41720086] | Zhao Q, Huang R, Wang C, Hu J, Nie R et | Cancer Cell | 2026 | 0 |
| TREM2 in neurodegeneration and diseases. [PMID:41792456] | ["Abdulkhaliq A", "Alasiri G", "Kim B", | Molecular psychiatry | 2026 | 0 |
| Alzheimer's Disease as a Disorder of Neuroimmune Dysregulation. [PMID:41745721] | Aranda-Abreu GE, Rojas-Durán F, Hernánde | Neurology international | 2026 | 0 |
| Molecular mechanism of Alzheimer's disease using integrated multi-omics. [PMID:41907842] | Alhusaini M, Mussa BM, Ilce BY, Alhaj H, | Frontiers in aging neuroscienc | 2026 | 0 |
| Enhancing TREM2 expression activates microglia and modestly mitigates tau pathol [PMID:40122810] | ["Chen Kai", "Li Fuyao", "Zhang Shuwen", | Journal of neuroinflammation | 2025 | 0 |
| Viral and non-viral cellular therapies for neurodegeneration. [PMID:41585268] | ["Srivastav Jyotsna", "Sharma Sachin"] | Frontiers in medicine | 2025 | 0 |
| Enhancing TREM2 expression activates microglia and modestly mitigates tau pathol [PMID:40122810] | ["Chen Kai", "Li Fuyao", "Zhang Shuwen", | Journal of neuroinflammation | 2025 | 0 |
| Neurodegeneration and Inflammation-An Interesting Interplay in Parkinson's Disea [PMID:33182554] | Marogianni C, Sokratous M, Dardiotis E, | International journal of molec | 2020 | 0 |
| Neurodegeneration and Inflammation-An Interesting Interplay in Parkinson's Disea [PMID:33182554] | Marogianni C, Sokratous M, Dardiotis E, | International journal of molec | 2020 | 0 |
| Multiple Sclerosis Pathology. [PMID:29358320] | Lassmann H | Cold Spring Harbor perspective | 2018 | 0 |
Debates (2)
Multi-agent debates referencing this entity
Does the cancer-cystatin-C-TREM2 pathway protect against tau pathology and other
closed · Rounds: 4 · Score: 0.66 · 2026-04-25
All participants identified brain delivery as a critical barrier, but no mechani
closed · Rounds: 4 · Score: 0.50 · 2026-04-16
Related Research
Hypotheses and analyses mentioning PHAGOCYTOSIS in their description or question text
SASP-Driven Microglial Metabolic Reprogramming in Synaptic Phagocytosis
Score: 0.643 · neurodegeneration · 2026-04-07
## Mechanistic Overview SASP-Driven Microglial Metabolic Reprogramming in Synaptic Phagocytosis starts from the claim th
Stage-Selective TREM2 Agonism — Boosting DAM Phagocytosis in Early Amyloid Phase
Score: 0.637 · Alzheimer's disease · 2026-04-04
## Mechanistic Overview Stage-Selective TREM2 Agonism — Boosting DAM Phagocytosis in Early Amyloid Phase starts from the
TREM2-Dependent Microglial Phagocytosis Acts as a Strain Selection Filter
Score: 0.636 · neurodegeneration · 2026-04-16
## Mechanistic Overview TREM2-Dependent Microglial Phagocytosis Acts as a Strain Selection Filter starts from the claim
CX3CR1 Agonism Enhances Microglial Phagocytosis of Extracellular Tau Seeds, Prev
Score: 0.630 · neurodegeneration · 2026-04-22
## Mechanistic Overview CX3CR1 Agonism Enhances Microglial Phagocytosis of Extracellular Tau Seeds, Preventing Template-
APOE4 lipid dysregulation and synaptic phagocytosis as early drivers of AD patho
Score: 0.604 · neurodegeneration · 2026-04-28
The debate supports carrying forward APOE4 lipid dysregulation and synaptic phagocytosis as early drivers of AD patholog
ITGAM/CD11b direct binding explains microglial phagocytosis blockade
Score: 0.582 · molecular biology · 2026-04-21
**Molecular Mechanism and Rationale** The proposed mechanism centers on alectinib's potential direct interaction with t
P2Y6R activation by UDP from damaged neurons drives microglial phagocytosis and
Score: 0.540 · neurodegeneration · 2026-04-21
## Mechanistic Overview P2Y6R activation by UDP from damaged neurons drives microglial phagocytosis and exosomal re-secr
TREM2-dependent microglial phagocytosis of tau seeds
Score: 0.530 · neurodegeneration · 2026-04-25
Cystatin-C-activated TREM2 microglia reduce tau pathology through enhanced phagocytosis of extracellular tau seeds. Crit
GluN2B-Regulated Microglial Phagocytosis of Tau Aggregates via CX3CR1 Signaling
Score: 0.491 · neuroscience · 2026-04-21
## Mechanistic Overview GluN2B-Regulated Microglial Phagocytosis of Tau Aggregates via CX3CR1 Signaling starts from the
GluN2B-Mediated Microglial Activation and Tau Phagocytosis
Score: 0.380 · neuroscience · 2026-04-27
This hypothesis proposes that GluN2B-containing NMDA receptors on microglia directly regulate tau protein clearance thro