gene

STMN1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about STMN1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

40Connections

0Hypotheses

0Analyses

21Outgoing

19Incoming

0Experiments

0Debates

Summary

Comprehensive coverage of STMN1 (Stathmin 1) in microtubule dynamics, neuronal development, synaptic plasticity, and neurodegenerative diseases including AD/PD/ALS.

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🧬 Gene Info

Gene Symbol	STMN1
Full Name	Stathmin 1
Chromosome	1p36.11
Function	is a 143-amino acid phosphoprotein that serves as a master regulator of microtubule dynamics in all eukaryotic cells.
Molecular Weight	19 kDa
Amino Acids	149 aa
Exons	5
Pathways	MAPK
GeneCards	STMN1
Human Protein Atlas	STMN1
Associated Diseases	Alzheimer's disease, Parkinson's disease, ALS
Interactions	CANCER, ERK, ERK1, ERK1/2, MEK
KG Connections	40 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

STMN1 — Stathmin 1

gene · 1889 words

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Pathway Diagram

graph TD
    STMN1["STMN1"]
    Ms{"Ms"}
    STMN1 -->|"therapeutic target"| Ms
    Cancer{"Cancer"}
    STMN1 -->|"inhibits"| Cancer
    Tumor{"Tumor"}
    STMN1 -->|"inhibits"| Tumor
    Apoptosis(["Apoptosis"])
    STMN1 -->|"therapeutic target"| Apoptosis
    Mapk(["Mapk"])
    STMN1 -->|"associated with"| Mapk
    neurodegeneration["neurodegeneration"]
    STMN1 -->|"implicated in"| neurodegeneration
    SMC1A["SMC1A"]
    SMC1A -->|"regulates"| STMN1
    ERK["ERK"]
    ERK -->|"inhibits"| STMN1
    SPR["SPR"]
    SPR -->|"therapeutic target"| STMN1
    CANCER["CANCER"]
    CANCER -->|"inhibits"| STMN1
    ERK1["ERK1"]
    ERK1 -->|"inhibits"| STMN1
    APOPTOSIS["APOPTOSIS"]
    APOPTOSIS -->|"therapeutic target"| STMN1
    style STMN1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (21)

Target	Relation	Type	Str
Tumor	inhibits	disease	0.65
Ms	therapeutic_target	disease	0.65
Cancer	inhibits	disease	0.65
Traumatic Brain Injury	expressed_in	disease	0.65
AND	expressed_in	gene	0.60
LDHB	expressed_in	gene	0.60
BRAIN INJURY	expressed_in	gene	0.60
Epithelial	therapeutic_target	cell_type	0.60
frontotemporal dementia	interacts_with	disease	0.60
SNCB	expressed_in	gene	0.60
GAP43	expressed_in	gene	0.60
HSPE1	expressed_in	gene	0.60
SNCG	expressed_in	gene	0.60
MAPT	expressed_in	gene	0.60
NDUFS6	expressed_in	gene	0.60
Apoptosis	therapeutic_target	pathway	0.60
Mapk	associated_with	pathway	0.60
Temporal Lobe	expressed_in	brain_region	0.55
Frontal Lobe	expressed_in	brain_region	0.55
Cortex	expressed_in	brain_region	0.55
Proteins	expressed_in	protein	0.50

Incoming (19)

Source	Relation	Type	Str
SMC1A	regulates	gene	0.80
GENES	expressed_in	gene	0.60
MEK	inhibits	gene	0.60
MAPK	associated_with	gene	0.60
ERK1/2	inhibits	gene	0.60
NDUFS6	expressed_in	gene	0.60
MAPT	expressed_in	gene	0.60
SNCB	expressed_in	gene	0.60
HSPE1	expressed_in	gene	0.60
SNCG	expressed_in	gene	0.60
GAP43	expressed_in	gene	0.60
SPR	therapeutic_target	gene	0.60
ERK1	inhibits	gene	0.60
ERK	inhibits	gene	0.60
CANCER	inhibits	gene	0.60
APOPTOSIS	therapeutic_target	gene	0.60
LDHB	expressed_in	gene	0.60
SNCB	co_expressed_with	gene	0.50
SNCG	co_expressed_with	protein	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning STMN1 in their description or question text

No additional research found