gene 1,998 words KG: HSPE1
Contents

HSPE1 — Heat Shock Protein Family E Member 1

🧬 Gene Info
Gene SymbolHSPE1
Full NameHeat Shock Protein Family E Member 1
Chromosome2q33.1
Protein TypeChaperone
Functionis a mitochondrial co-chaperone protein that functions as a heptameric ring complex together with HSP60 (encoded by HSPD1).
Primary ExpressionUbiquitous, high in brain
Subcellular LocalizationMitochondria (matrix)
Molecular Weight10 kDa
UniProt IDP61604
NCBI Gene ID3336
OMIM600351
GeneCardsHSPE1
Human Protein AtlasHSPE1
Associated DiseasesAlzheimer
InteractionsBECN1, BNIP3, BNIP3L, CEBPB, DDIT3, DNM1L
KG Connections114 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

Related Hypotheses (6)

Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.91
TFAM overexpression creates mitochondrial donor-recipient gr
Score: 0.73
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
HSP90-Tau Disaggregation Complex Enhancement
Score: 0.55
Chaperone-Mediated APOE4 Refolding Enhancement
Score: 0.68

Related Analyses (6)

Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (1)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40

See Also (15)

Apoptosis in Neurodegeneration
entity · KG edge: expressed_in
Genes
index · KG edge: biomarker_for
BAG3 Gene
gene · KG edge: expressed_in
BECN1 Gene
gene · KG edge: inhibits
BNIP3 Gene
gene · KG edge: inhibits

Knowledge Graph (12 edges)

BNIP3 inhibits HSPE1
VDAC1 inhibits HSPE1
FUNDC1 inhibits HSPE1
TOMM20 inhibits HSPE1
TIMM9 inhibits HSPE1
TIMM17B inhibits HSPE1
OMA1 inhibits HSPE1
TIMM23 inhibits HSPE1
MTOR inhibits HSPE1
NRF1 inhibits HSPE1

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