gene

NDUFS6

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NDUFS6: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

43Connections

0Hypotheses

0Analyses

27Outgoing

16Incoming

0Experiments

0Debates

Summary

NDUFS6 (NADH:Ubiquinone Oxidoreductase Core Subunit S6): mitochondrial complex I iron-sulfur subunit essential for electron transport, ATP production, and implicated in Leigh syndrome, mitochondrial complex I deficiency, Parkinson's disease, and neurodegeneration.

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🧬 Gene Info

Gene Symbol	NDUFS6
Full Name	NADH:Ubiquinone Oxidoreductase Core Subunit S6
Chromosome	5p14.3
Protein Family	Complex I subunit family (NADH dehydrogenase)
Function	is a critical iron-sulfur subunit of mitochondrial complex I (NADH:ubiquinone oxidoreductase), the largest enzyme of the mitochondrial electron transport chain.
Molecular Weight	13 kDa
Amino Acids	124 aa
UniProt ID	O75306
NCBI Gene ID	4729
Ensembl ID	ENSG00000145494
OMIM	602152
GeneCards	NDUFS6
Human Protein Atlas	NDUFS6
Associated Diseases	Alzheimer's disease, Parkinson's disease
KG Connections	43 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: NDUFS6 — AlphaFold O75306 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

NDUFS6 Gene

gene · 1646 words

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Pathway Diagram

graph TD
    NDUFS6["NDUFS6"]
    Als{"Als"}
    NDUFS6 -->|"regulates"| Als
    Ms{"Ms"}
    NDUFS6 -->|"regulates"| Ms
    NDUFA1["NDUFA1"]
    NDUFS6 -->|"associated with"| NDUFA1
    CBL["CBL"]
    NDUFS6 -->|"associated with"| CBL
    PDGFRB["PDGFRB"]
    NDUFS6 -->|"associated with"| PDGFRB
    HSP90AB1["HSP90AB1"]
    NDUFS6 -->|"associated with"| HSP90AB1
    CRKL["CRKL"]
    NDUFS6 -->|"associated with"| CRKL
    DOCK1["DOCK1"]
    NDUFS6 -->|"associated with"| DOCK1
    NDUFA12["NDUFA12"]
    NDUFS6 -->|"associated with"| NDUFA12
    YWHAH["YWHAH"]
    NDUFS6 -->|"associated with"| YWHAH
    NDUFS5["NDUFS5"]
    NDUFS6 -->|"associated with"| NDUFS5
    neurodegeneration["neurodegeneration"]
    NDUFS6 -->|"implicated in"| neurodegeneration
    NDUFA2["NDUFA2"]
    NDUFA2 -->|"associated with"| NDUFS6
    style NDUFS6 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (27)

Target	Relation	Type	Str
Traumatic Brain Injury	expressed_in	disease	0.65
Als	regulates	disease	0.65
Ms	regulates	disease	0.65
AND	expressed_in	gene	0.60
LDHB	expressed_in	gene	0.60
SNCG	expressed_in	gene	0.60
STMN1	expressed_in	gene	0.60
GAP43	expressed_in	gene	0.60
HSPE1	expressed_in	gene	0.60
NDUFA1	associated_with	gene	0.60
CBL	associated_with	gene	0.60
PDGFRB	associated_with	gene	0.60
HSP90AB1	associated_with	gene	0.60
CRKL	associated_with	gene	0.60
DOCK1	associated_with	gene	0.60
NDUFA12	associated_with	gene	0.60
YWHAH	associated_with	gene	0.60
NDUFS5	associated_with	gene	0.60
MAPT	expressed_in	gene	0.60
SNCB	expressed_in	gene	0.60
Cortex	expressed_in	brain_region	0.55
Temporal Lobe	expressed_in	brain_region	0.55
Frontal Lobe	expressed_in	brain_region	0.55
Proteins	expressed_in	protein	0.50
SNCB	co_expressed_with	gene	0.50
SNCG	co_expressed_with	protein	0.50
SNCB	co_mentioned	gene	0.40

Incoming (16)

Source	Relation	Type	Str
SNCB	expressed_in	gene	0.60
HSPE1	expressed_in	gene	0.60
STMN1	expressed_in	gene	0.60
SNCG	expressed_in	gene	0.60
GAP43	expressed_in	gene	0.60
MAPT	expressed_in	gene	0.60
GENES	expressed_in	gene	0.60
BRAIN INJURY	expressed_in	gene	0.60
NDUFA2	associated_with	gene	0.60
CAV1	expressed_in	gene	0.60
CTNNB1	expressed_in	gene	0.60
LDHB	expressed_in	gene	0.60
HSPE1	co_expressed_with	gene	0.50
MAPT	co_expressed_with	gene	0.50
GAP43	co_mentioned	gene	0.40
MAPT	co_mentioned	gene	0.40

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning NDUFS6 in their description or question text

No additional research found